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- 积分
- 17983
- 威望
- 17983
- 包包
- 26159
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: n1 o) W* w3 |- qVolume 38, Issue 5( B7 T7 V2 I! @
On the cover: Regulation of metabolic pathways in the immune system provides # g! `$ N3 P3 L- A9 c
a mechanism to actively control cellular function, growth, proliferation, and / }; p, K$ O- b9 ]2 Q8 _+ k$ s
survival. However, the contribution of microRNAs to the regulation of cellular % U0 e2 D3 v2 {7 i9 E% U3 _
metabolism in the immune system is unclear. In this issue of Immunity, , v% D Q r9 C7 ^ b+ X
Henao-Mejia et al. (984–997) show that the miR-181 family is a critical @- P( I3 A0 R3 T" w5 t2 z
determinant of cellular metabolism, and therefore it is essential to support the
4 m2 F% f+ y. ?high biosynthetic demands of lymphocyte development. In particular, regulation : @# q: j2 H; l$ m8 ~& b
of cellular metabolic pathways by miR-181 is absolutely required for early
- u2 V: Y2 h4 R' _& l4 X. rnatural killer T cell development. The cover cartoon depicts a lymphocyte that 5 {0 V1 I7 X; d& h% v! W5 M
necessitates the presence of miR-181 (represented as an electrical plug) to
! N: [; |' L) o$ \; V3 ~; m* \2 `% h, wmaintain a robust metabolism. Thus, in the absence of miR-181 (unplugged 3 X o6 W9 |4 ? D
status), the lymphocyte lacks the energy to efficiently carry out normal 7 r; a- F' h! `0 f1 l
functions. Image created by Gustavo Zapata.6 Z+ b6 P- x: g1 \8 G8 A1 l% k
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发表于 2013-5-24 20:52
发表于 2013-5-24 21:18
