[全文]丁盛Nat Methods新文章－－提高iPS诱导效率200倍

芷瞻

Nat Methods. 2009 Oct 18.【Epub ahead of print】: q; u7 Z4 L4 _3 r9 O" p
% j  c8 W5 T# Z8 C
& I% A0 F7 U" S7 }+ l
A chemical platform for improved induction of human iPSCs." o/ o" _4 }- D  t

8 M, g( K" ~% D1 ]Lin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, Lin X, Hahm HS, Hao E, Hayek A, Ding S.3 G9 J  Z: x" c- y; b$ ]$ x
Department of Chemistry, The Scripps Research Institute, La Jolla, California, USA.
4 x; A. I& H7 b' k; g3 p# @# u+ {- ~* j! Y
The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, nonviral methods for reprogramming human somatic cells.- Z4 L0 ]' Z8 x  ?5 n$ T
3 z$ p& `/ C7 T# y7 S( ]
PMID: 19838167 c+ X0 V% B2 B$ `

- P/ U  I/ v; p4 ~5 |

jianlindunev

学习中，感谢

好玩301

怎么下载不了了？仍然感谢

sunyucheng

ddddddd

应菜

能下，谢谢

lorey

顶！好文章

dengyanfei

非常感谢

carolshf

非常感谢

风源

感谢

mmssyyee

请问你有没有这篇文章的methods呀？我在网上下载不了，有的话能不能给我一份啊，谢谢！！！