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Nat Methods. 2009 Oct 18.【Epub ahead of print】
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8 d/ V( e$ ~: rA chemical platform for improved induction of human iPSCs., I. m7 U5 g0 `: A8 @
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Lin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, Lin X, Hahm HS, Hao E, Hayek A, Ding S.5 }4 R+ ]& s' y
Department of Chemistry, The Scripps Research Institute, La Jolla, California, USA." c, P( R$ U3 F- M# _. x5 E
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The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, nonviral methods for reprogramming human somatic cells.
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9 C/ _& B+ D7 J5 d4 {6 TPMID: 1983816
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发表于 2009-10-21 20:20
发表于 2009-10-22 15:52
