[全文]丁盛Nat Methods新文章－－提高iPS诱导效率200倍

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Nat Methods. 2009 Oct 18.【Epub ahead of print】
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A chemical platform for improved induction of human iPSCs.
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) A) ^- L/ T6 a0 w+ q$ nLin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, Lin X, Hahm HS, Hao E, Hayek A, Ding S.! F5 d( C; Q' x
Department of Chemistry, The Scripps Research Institute, La Jolla, California, USA.
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The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, nonviral methods for reprogramming human somatic cells.
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PMID: 19838167 I. Q  p8 t' [; f( \1 K3 O
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