microRNA与干细胞

细胞海洋

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，microRNA在干细胞的自我复制、定向分化和组织再生中，都起着十分重要的作用。它是干细胞特性、维持、转化功能的一个关键的调节者，是当前干细胞调节研究的一个重点。最近，Gangara Ju. VK和Lin H在Nature Stem Cell作了一篇综述，系统的总结了microRNA对干细胞调节作用
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) }2 y* t1 E# b1 K. B但是，microRNA对干细胞的调节作用还远远不止于此。它还参与细胞周期、细胞重建(Reprograming)、多能干细胞生成、信号传递、特异分化、Riches、修复、再生、变异、代谢等所有过程

maxiaorongqp

有这部综述的全文吗

细胞海洋

MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells, Where It Causes Post-Transcriptional Attenuation of Nanog and LRH1 # D$ ?4 X+ M; o3 X
MicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells
5 A9 y% a6 q+ j1 @4 ?" vMicroRNA Regulation of Stem Cell Fate , |8 V- ~. {/ _
MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells . u/ W4 [) w& O: s8 O3 M1 y6 W
MicroRNA-145 to control human embryonic stem cell (hESC) pluripotency and differentiation
. `- e# i/ E0 J+ J$ n; b9 EA feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination
) ^! x9 u$ o# Z) c; IAn embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network
* X8 y+ o2 w; rca-let-7 microRNAs in development, stem cells and cancer 1 i7 }! G5 }9 B& O7 I( O: M
Ca-Metastasis-from dissemination to organ-specific colonization
3 {7 h4 u: X3 iCell Cycle Regulation by MicroRNAs in Embryonic Stem Cells ( P3 ?4 O  j' v8 m
Chromosome instability is common in human cleavage-stage embryos
8 D9 G/ v/ @6 c- N, ]8 R& [- h; {- SComprehensive MicroRNA Profiling Reveals a Unique Human Embryonic Stem Cell
0 U+ K2 L8 i% LConnecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells + Q" E2 q5 s' K2 }0 S( Q
Differentiating human multipotent mesenchymal stromal cells regulate microRNAs   b8 f0 X* S% {, |2 R4 D9 x
Embryonic stem cell–specific microRNAs regulate the G1-S transition and promote rapid proliferation
9 P: G" o0 m1 w) o6 QHMGA2, MicroRNAs, and Stem Cell Aging
! F4 ?! p2 k/ g# `  _4 h5 aLin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing # t6 ~8 K, Y8 I/ y9 ?3 U
Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA ) T) X; Y% l6 J
Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation
3 o' H2 o9 o+ T: EMicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells
1 d6 @3 F; |1 F- z& EmiR-145 in Stem Cell Differentiation 9 Y5 [* C8 r9 V7 ?
MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells * K! V$ h; H/ Y$ {
miR-9 and TLX-chasing tails in neural stem cells 6 i* t( r/ g' G/ Q
Multipotent adult germline stem cells and embryonic stem cells have similar microRNA profiles * Q4 q& z; ]2 b0 r
Pluripotent stem cell lines + Z  P! h7 I$ g; r9 r: |2 S
Regulatory circuits underlying pluripotency and reprogramming 5 f: v6 d  {7 \; e- I
sc-MicroRNAs to , and coding regions modulate embryonic stem cell differentiation 3 X9 j/ X: e* m, e
sc-MicroRNAs-key regulators of stem cells
2 i# q& `0 a% N4 l. j, B, zMicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells
4 R  [- l/ h& [! dStem cells-MicroRNAs promote differentiation
8 G% R( u* A# [2 tsc-MicroRNA Expression in Multipotent Mesenchymal Stromal Cells / o* o3 F" f9 A' U" U" J7 |
Stem cells- MicroRNAs promote differentiation
. U- P$ @) x6 t! `0 x/ d/ Q2 Q4 P. fMicroRNA regulation directs lineage-and developmental stage-specific transgene expression in hematopoietic stem cell progeny

guanjiyu

谢谢分享

fuguangbo

好文章！谢谢！

sacia

好东西~楼主辛苦了！！

ouyi2738

Embryonic stem cell–specific microRNAs promote induced pluripotency

sdyinong

谢谢

yaner

有全文吗

Rainnie

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，m ...' A4 ~. @9 N7 J3 ?
细胞海洋 发表于 2009-10-29 18:58

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   全文有么？