microRNA与干细胞

细胞海洋

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，microRNA在干细胞的自我复制、定向分化和组织再生中，都起着十分重要的作用。它是干细胞特性、维持、转化功能的一个关键的调节者，是当前干细胞调节研究的一个重点。最近，Gangara Ju. VK和Lin H在Nature Stem Cell作了一篇综述，系统的总结了microRNA对干细胞调节作用6 ]- l3 t4 I$ V: G' o* d
' V  `8 J7 S: b6 \9 s* b0 g

; Z+ d, Y* i8 }  P- x/ J& ?, r* D# g
5 n5 `+ U* X5 s7 Y) u& C6 i: I; x7 Z

& P+ I0 _3 R* w6 ^8 A$ z0 s但是，microRNA对干细胞的调节作用还远远不止于此。它还参与细胞周期、细胞重建(Reprograming)、多能干细胞生成、信号传递、特异分化、Riches、修复、再生、变异、代谢等所有过程

maxiaorongqp

有这部综述的全文吗

细胞海洋

MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells, Where It Causes Post-Transcriptional Attenuation of Nanog and LRH1 6 J7 {2 C, @% h. J
MicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells 2 Z& B' M5 H( x% |
MicroRNA Regulation of Stem Cell Fate
  ~* U; z( `% v- ]MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells ( D, E) i- V4 {% k$ P
MicroRNA-145 to control human embryonic stem cell (hESC) pluripotency and differentiation ' l9 Q8 \+ X( I$ g9 Q( @" V- L
A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination 0 I" y, b& D1 w/ I/ K
An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network
% R& B2 ~4 ~. K$ b' T1 G9 ^+ ^ca-let-7 microRNAs in development, stem cells and cancer   |& I# X* L2 B4 @/ ^8 L0 `
Ca-Metastasis-from dissemination to organ-specific colonization 9 A8 b! t; d- C9 v+ R/ @
Cell Cycle Regulation by MicroRNAs in Embryonic Stem Cells ; Q& p4 q! `+ ^& W$ G2 c; W% q. E
Chromosome instability is common in human cleavage-stage embryos
5 v$ o9 R( H( j7 x, P! dComprehensive MicroRNA Profiling Reveals a Unique Human Embryonic Stem Cell 8 g# @/ v& O# n- P
Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells
' e! O: i9 _4 {0 J7 PDifferentiating human multipotent mesenchymal stromal cells regulate microRNAs # x9 y4 m$ f* u8 [
Embryonic stem cell–specific microRNAs regulate the G1-S transition and promote rapid proliferation $ ]6 ?& u1 [2 t. `2 Z
HMGA2, MicroRNAs, and Stem Cell Aging
* z. D' n  q3 P2 lLin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing / O' D2 _5 S  c- U/ P$ P" p3 B
Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA 9 o) F. g( d  H
Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation & X4 N* y) S3 Z( \
MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells 5 }  `" t; v, }8 B1 `8 k: q9 l9 A
miR-145 in Stem Cell Differentiation 4 C; {4 Z  I! x, ~- {" p2 [
MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells ' ]. A" }7 d& _4 y1 R% d7 N) {
miR-9 and TLX-chasing tails in neural stem cells # ~8 ?9 P* v. q4 B3 k) |5 O/ Z
Multipotent adult germline stem cells and embryonic stem cells have similar microRNA profiles
% T7 C6 G" H7 Z# H* bPluripotent stem cell lines
; [! D! _6 \2 Q) ORegulatory circuits underlying pluripotency and reprogramming   G" J/ A* k. {5 v0 K% B" r
sc-MicroRNAs to , and coding regions modulate embryonic stem cell differentiation
: o8 z: f- x7 S/ ]. l, d  q* Nsc-MicroRNAs-key regulators of stem cells
* S, z  K+ c' k" d4 F1 P6 NMicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells
+ i; S( F  f5 L' IStem cells-MicroRNAs promote differentiation
1 ?& H5 M1 g% \4 @* i, Wsc-MicroRNA Expression in Multipotent Mesenchymal Stromal Cells
% z& O3 f$ L, Q) p5 t' {6 I  `: R3 xStem cells- MicroRNAs promote differentiation
6 g8 R: s0 g3 J, {* ~) V* R9 mMicroRNA regulation directs lineage-and developmental stage-specific transgene expression in hematopoietic stem cell progeny

guanjiyu

谢谢分享

fuguangbo

好文章！谢谢！

sacia

好东西~楼主辛苦了！！

ouyi2738

Embryonic stem cell–specific microRNAs promote induced pluripotency

sdyinong

谢谢

yaner

有全文吗

Rainnie

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，m ...4 q  ?4 f1 k9 v8 P+ _6 `2 ~
细胞海洋 发表于 2009-10-29 18:58

& @8 Q0 i: u8 K0 ]
, }+ }/ P6 W  |# v. a

* v3 s0 a" n  U5 |   全文有么？