microRNA与干细胞

细胞海洋

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，microRNA在干细胞的自我复制、定向分化和组织再生中，都起着十分重要的作用。它是干细胞特性、维持、转化功能的一个关键的调节者，是当前干细胞调节研究的一个重点。最近，Gangara Ju. VK和Lin H在Nature Stem Cell作了一篇综述，系统的总结了microRNA对干细胞调节作用# s, H; I+ z: ?
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( y' t5 t5 G( y) T  R但是，microRNA对干细胞的调节作用还远远不止于此。它还参与细胞周期、细胞重建(Reprograming)、多能干细胞生成、信号传递、特异分化、Riches、修复、再生、变异、代谢等所有过程

maxiaorongqp

有这部综述的全文吗

细胞海洋

MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells, Where It Causes Post-Transcriptional Attenuation of Nanog and LRH1
5 R% K! R7 f" I3 wMicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells 9 g  w7 q) L, o2 Z
MicroRNA Regulation of Stem Cell Fate
; ^/ \! l+ w0 l4 k# E0 J* R! xMicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells $ P' j0 \! z: y; C- g2 M& H" `
MicroRNA-145 to control human embryonic stem cell (hESC) pluripotency and differentiation 6 v% e6 c$ Z/ h* J1 {" ?: I
A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination
2 |" k& s3 _5 c3 F* G% zAn embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network
: @( j  k8 k: K: @4 Nca-let-7 microRNAs in development, stem cells and cancer / o- l6 h; g  G; x) k3 ~0 F8 `
Ca-Metastasis-from dissemination to organ-specific colonization
  W- m% P! L$ E" G" w" a; C: _6 n" mCell Cycle Regulation by MicroRNAs in Embryonic Stem Cells
$ m9 Z. C. |! y  S2 L3 p" h% }Chromosome instability is common in human cleavage-stage embryos ! E& ^& i3 X6 Y  j+ s, u
Comprehensive MicroRNA Profiling Reveals a Unique Human Embryonic Stem Cell : c6 g9 o6 ~3 h! O! v
Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells
+ M% ~$ Q# a0 K9 c, c% I, [& [Differentiating human multipotent mesenchymal stromal cells regulate microRNAs " n6 F0 E# V% T* [0 ^6 R1 a& {
Embryonic stem cell–specific microRNAs regulate the G1-S transition and promote rapid proliferation
* W8 X" j( m" {+ b; A+ ^8 h( gHMGA2, MicroRNAs, and Stem Cell Aging
* H9 v6 P0 k! n. QLin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing
& r  O9 _" u! ?. |7 dLin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA $ R2 `* v8 C5 M; ?
Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation 2 _$ G' |. _4 H) ^
MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells ) m( ~! l& _" r# m5 ~0 P3 C
miR-145 in Stem Cell Differentiation
- P4 C9 S- X0 `! M& N  I" H) y6 ?MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells ( M3 |6 e  @$ I8 r5 W
miR-9 and TLX-chasing tails in neural stem cells ; l' O" _  }1 W8 P) D0 ~, _( B/ ^
Multipotent adult germline stem cells and embryonic stem cells have similar microRNA profiles 4 C9 k* x7 R* m/ ]8 F+ a' S
Pluripotent stem cell lines 2 I5 L+ U6 T, B. v8 ]& Y* y
Regulatory circuits underlying pluripotency and reprogramming
# _) i# q$ L; `1 @" u9 ^( d1 w: hsc-MicroRNAs to , and coding regions modulate embryonic stem cell differentiation
* x& D. }  ^" j- X2 N8 Bsc-MicroRNAs-key regulators of stem cells
, n$ b+ e8 y) z( v  ]8 uMicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells
- t' C* P3 ^; K4 c" aStem cells-MicroRNAs promote differentiation / j7 a% C2 Z) y/ k9 F& u- x4 s
sc-MicroRNA Expression in Multipotent Mesenchymal Stromal Cells & }  l( d  v$ \: `5 ~; l2 s/ h
Stem cells- MicroRNAs promote differentiation ( J! n" b2 ^5 @; E
MicroRNA regulation directs lineage-and developmental stage-specific transgene expression in hematopoietic stem cell progeny

guanjiyu

谢谢分享

fuguangbo

好文章！谢谢！

sacia

好东西~楼主辛苦了！！

ouyi2738

Embryonic stem cell–specific microRNAs promote induced pluripotency

sdyinong

谢谢

yaner

有全文吗

Rainnie

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，m ...  ?+ h  h" Q  \3 D; B
细胞海洋 发表于 2009-10-29 18:58

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7 R+ x% u# f& L3 R1 T8 M   全文有么？