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Mesenchymal stem cells: the fibroblasts’ new clothes?% m. k" z6 S E; y; a W H/ L
ABSTRACT
* M# d. M4 w* n, P/ `Mesenchymal stem cells are adherent stromal cells, initially isolated from the bone marrow, characterized by their ability# y$ p( a" Y0 x5 t: j0 F
to differentiate into mesenchymal tissues such as bone, cartilage and fat. They have also been shown to suppress
) [& N7 p% `$ ?3 Eimmune responses in vitro. Because of these properties, mesenchymal stem cells have recently received a very high profile.5 s( f% \) m5 a. q( C2 Q2 @
Despite the dramatic benefits reported in early phase clinical trials, their functions remain poorly understood.
, b$ ^) a; b. h% p6 ]" rParticularly, several questions remain concerning the origin of mesenchymal stem cells and their relationship to other* {5 W! A* p( I- j- ?
stromal cells such as fibroblasts. Whereas clear gene expression signatures are imprinted in stromal cells of different
) g/ P1 g: S6 Hanatomical origins, the anti-proliferative effects of mesenchymal stem cells and fibroblasts and their potential to differentiate
9 W8 ]# [7 c @: l. kappear to be common features between these two cell types. In this review, we summarize recent studies in the
* X) I& l& U5 H% t$ rcontext of historical and often neglected stromal cell literature, and present the evidence that mesenchymal stem cells and( H: i, H$ t( Z
fibroblasts share much more in common than previously recognized.3 ~- C1 |+ n7 ] F
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发表于 2010-1-7 15:38
发表于 2010-1-8 17:32
