老狼的个人空间记录

sunsong7

"genetic mutation" should be exactly as "gene self-editing"- A5 p5 s) u: M7 a' s. p' b/ M
2017-12-1 13:17
' X; |1 e, r  j7 {3 p# W2 xBioreactor in vivo would be the terminator of illness.2 K% K& f- M4 K
2017-11-20 23:09. x' {6 f8 \1 F; p
renew tech：剔除衰老（病变）细胞占位可以恢复青春。
  L4 L) ?! X* V$ g2017-10-23 12:50
5 ?! S( A, m" T魔不疯，鬼不魅； 道非盗，仙非妖；神无形，兽无极。
- ?6 V( T! k3 f, |' F2017-9-30 10:585 [4 Z1 G6 }  E, o' K) u
Life 3.0——from decoding and coding to reading and writing
& a9 o& X/ K2 j+ V8 L2017-9-21 22:32; D0 @4 z( t% W) `
理论创新：亮明立场——先颠覆，再完善9 g) C% n' F' D* P
2017-2-7 00:07
$ S% k# G0 [  b5 E$ N干细胞第二定律：与细胞外基质共同构成多潜能；
2 L! J2 z* m$ R1 d( f! \2017-1-3 11:14
& e! B3 M  p$ C干细胞第一定律：全生命周期保持增殖分化能力；
- O7 h( N+ c/ d2 e4 q/ s  }2017-1-3 11:135 s3 a  S, D/ j
NgAgo——Never give A guideline operated！* h9 i* \8 X6 o% r( x
2016-12-1 10:09. P3 N8 c& q- l- I! E  M' C
表观遗传—— 一切皆可改变  一切皆有可能# |9 J( H: ~" F' q' }: H* P) s: H
2016-8-17 23:37
% \+ a6 {0 r  f. o子曰：吸血鬼疗法——养儿防病 养孙防老
) x4 ?, J; y) E! ?; R, y$ v" g/ q2016-5-23 12:05" A# g. M% g3 s( t4 Q5 g& J
NgAgo——Debug tool kit for mammal cells
+ B8 B. u( X0 S3 S3 i2016-5-9 13:09
) i. k8 H& i' O公理之外 皆需证明； 科学命题 皆可证伪。8 o$ c- g% C, v8 H* F) V
2016-1-2 00:208 w$ P' x9 N  y2 _9 E: J8 D' ]2 E
低氧——破坏线粒体功能、诱发炎症、导致基因突变
8 n" M. o8 z8 ?; }- U. P5 Q2015-12-16 20:19/ U7 g% [/ H4 e1 A& O1 h* F. N
癌症——炎症部位组织再生过程中细胞去分化失控形成的幼稚化新生物。% n+ l3 H' d. D! W
hcoohboy: 一个有趣的假设~但是没有炎症就一定没有癌症吗？ (12-18 16:16)1 y, z; @/ S5 G* {' s' H
sunsong7: 炎症与癌症同在，Hanahan D, Weinberg R A. Hallmarks of cancer: the next generation[J]. cell, 2011, 144(5): 646-674. (12-19 19:45)
' L8 f; d4 K. a2 Ahcoohboy: 3ks~ (12-24 16:45)/ [1 J) Z* L, B
2015-11-18 15:54
" Z5 T, q& O% v1 l! k' O抽象世界与客观世界的真理判别标准是不同的： 在虚拟数学世界里，逻辑是一切命题的唯一审判标准； 在客观物质世界里，证伪是一切定律的最终审判依据。
% L# D$ a  ], d% \  r7 x9 V2 T2015-5-20 14:13
$ S2 W0 e- u; X, m8 f3 a 传统生物学将死：进化论=自然神论   基因轮=宿命论   细胞论=活力论翻版。    现代生物学曙光乍现：系统生物学=数学 结构生物学=物理学 合成生物学=工程学
4 q$ L. @' w4 q6 {" Yhelong: 系统生物学是把细胞、基因、进化、物理学、信息学（数学）、工程学等都打包起来的所谓新学科，目前只做到了简单组合，还没有达到系统集成阶段。合成学更多偏向于化学。 (4-21 19:28)3 P, T1 R& G' w, o
sunsong7: 方向对头，努力总会有结果的 (4-21 20:05)
, ~2 ~) |* P  q9 K2015-4-21 16:46
, s3 ~% {( y9 Z5 Q- Usearch and research is just disassembling the creature.
7 X: u7 }$ @4 F' B/ E2015-4-7 17:01: p: i, U. x- Y! Q
selection is  the act of intelligence  k) l/ c3 J* ?- i1 F' |
2015-4-7 13:49# E0 ]6 L+ {: k( D- R- f
Genome fusion create neoplasm
6 v7 @, N, c' f7 r1 d; n2015-1-20 13:104 G& C, ?+ h6 W& `$ R
STAP——Stupid Trick  Against Professional 9 x* P  P4 ?- }( u. h9 L
2015-1-1 19:29% ~4 ?9 P2 N- T. h4 e! W
information=structure=negentropy
* e4 g( J8 b/ R* q& `( Z4 y% |2014-7-22 17:36
! j( K6 o2 o. yNatural mutation does not result in new functional genes 0 f8 @5 L) H8 N
2014-7-3 14:06
! O+ ?1 E2 R0 k$ M# T: u2 `life is wisdom creation instead of natural evolution
+ I3 q- D, b$ k& J2014-3-27 09:33" h7 G5 @2 `6 j  E; O
let us explore the source code of life !; j* \! G; p8 w
2014-3-11 13:113 B7 m; ]$ G2 z5 l) X
bio-manufacturing——processing，machining，casting，printing，3D prototyping，duplicating，cloning，life replicating.
( I( h; D2 [( }6 r$ Z2013-10-7 23:06
) V( A% Z' F) M$ Einduced abortion would give the key for curing cancer 
9 _  Y9 ?9 @, c9 e4 Z/ T# Z3 }1 R2013-10-2 23:33
& u4 w; u$ Z0 X“key breakthrough” in molecular biology are entertainments9 R0 ^' l* w, d0 f# b
2013-6-16 11:50; b+ W3 k9 `3 z1 p0 K# w
Rules Of Living：trial-and-error exploring，survival takes the legitimacy5 Q3 ~- r* o0 q( J% U$ f1 v
2013-6-16 11:27
& N$ ?: q* u. G/ eLife is a set of debuging programs$ H# E! m8 G, p# G# t# y0 _
2013-6-15 18:406 h3 s  J  c; v3 ]% E
current biology is closed，destined and agnostic，it is  the only contribution is to kill cells. g' o0 r  K  _
2013-5-2 08:549 z$ b' q  b  ~( ~, U
information，energy and construction are the new base stone of biology，instead of evolution，gene and  cell  tales
- B' P( o5 e$ }2013-5-2 00:51! f; \$ s6 U9 n- _
virus is the messager of  the universal life network
( p+ }9 F. ~& L" t5 g2013-4-18 14:33: G9 f- s# _; H7 x1 E- u1 }# V! h
Genetic information doesn't improve cancer risk prediction
5 B, A  Y- s; L2013-4-1 09:20) g% n% A/ ^) K4 e
There is no early diagnosis of cancer，but early prevention of it
8 g5 F7 ?" a6 E2013-3-27 09:17
# E$ @) ?5 ]! q8 k1 q. Ihypoxia maintains stemness or carcinogenicity
$ q0 l$ S& L& L/ X2013-1-2 05:21+ q5 l3 I. f8 R, y% I. e
cancer is the living fossil records on origin and evolution of human being
! `) I& i6 _9 b: N2012-12-9 23:314 S5 d/ [, ^5 \/ d7 Z* j
information island results cancer% j# P0 S* M0 u& w# U3 U, d
2012-12-9 05:23
3 }; E4 L. G4 \life is digital game5 p  A1 B2 b9 T( G0 J
2012-11-10 00:17
* n5 P. t$ e$ n0 y: U# Gcancer ——severe abstinence reaction of cells to niche addiction1 t* d' p, X% K) M- {2 L" U9 t
2012-9-28 12:11
6 \. K) [) d; k% U未来生物学终将回归物理(熵)及数学(分形)的美感. b1 P, `7 l* D# N6 X% L5 [2 c
biomater: 熵理论适用于任务物质。。。。也适合于生命 (9-26 09:28)
% k5 W; v; T' w# Y" \% S0 ?2012-9-25 21:22
: [% C! P8 h4 j2 ]: H# C# Ymembrane holds the key to life# V4 [; r3 w+ l" F' d  s' Z
2012-8-19 20:24% M4 I" r; @5 ~4 @5 T
Cancer is the default state of cells% B" M4 O; J* j" w) l
2012-6-26 22:173 s0 {$ x2 I- A* P2 {: j+ }" c
mainstream cancer theories could be overthrown！7 q1 {/ q- g  _; e1 K
2012-6-25 15:43
" U2 b  E* N; l; O& e5 Ocarcinogenesis has nothing to do with the gene mutations but is  the result of niche reprogramming...
, }  u# v: z9 J# K4 z9 e2012-6-7 09:36
, P! u! M5 V% {$ o% Yevery living organism connected with the water， one cell one world
7 C5 a* J" d  {2012-4-19 22:06
  h+ q7 M' u- p# D- ^' achemical structure of cancer cell determines it's biological function...
3 v5 I: T" W9 K) o  B2012-4-7 17:56* ]2 O' A, {' Z4 D6 `/ c
Mann tracht und Gott lacht
: J* i4 K( ~- c% c2012-3-24 21:348 ]$ Z( x- q& ~' P5 [6 f/ f2 k9 R
Darwinism or genetic determinism is a fairy tale！
, l+ h6 z& S5 G7 Q3 A2012-3-13 15:18& x, A" V  y' r
niche isolation is essential for cancer speciation
4 v  W; e3 w( q4 I6 m+ s$ N! w+ c2012-3-12 12:07; y% z5 R1 Z7 B& ^( H, U( a9 ^
Hybridization Creates New Species，Mutation results species extinction! o0 Q4 C) D+ C
2012-3-11 18:219 W2 V, c" K: y( l
ROCK may join the niche reprogramming...
- _+ d/ n$ C& |5 c$ y) qyuhaoze: 这是篇文献吗？ (3-9 10:41)
& p  j4 @# ^' }* E% `! F' Ssunsong7: http://www.stemcell8.cn/home-space-uid-6268-do-blog-id-1211.html 突破：病人体细胞及肿瘤细胞长期体外培养（附原文） http://www.stemcell8.cn/thread-51419-1-1.html (3-9 10:46)' S7 X. v( O* ]1 @4 z
yuhaoze: 啊， 我看过这篇，还顶了呢，谢谢哈 (3-9 14:37)2 B+ k  o( _6 N# }
2012-1-19 10:527 Q# U# h+ }1 ?2 b: e5 h4 w
oncogenes are pseudoscience; l" _, i- C* R* y3 U/ R/ ]# h
2011-12-29 13:55
$ H  k5 d, ^# D/ e7 ~1 rgene mutation leads to variation or extinction, not new species" @) ]( r6 P2 j0 r
2011-12-29 13:28
: B$ Q! a- K# @7 Q# ^- q; D( {oncogenesis is non-Darwinian event& Q# c( x4 H0 _% e3 A, u; m
2011-12-28 22:568 W$ C) B2 P( _" q4 q
disorganization activate neurogenesis activate oncogenesis   / F. a- _  ]- b+ z- g8 M
2011-12-22 23:38. x- U  G5 J1 o0 P. d8 l7 V1 y9 U
MSC is cell feeder，tissue scaffold，immune firewall and biological glue
4 M) x% T& w* R+ V2011-12-19 19:46# v( S7 M% L* N7 z+ e/ b( r: Y
cancer is Noah's Ark（species carrier and life explorer）1 T" N. `4 ?, v, {& p3 t0 b5 R
2011-12-10 09:46
! I1 q+ E& W( v; Rcell fusion create new species, gene mutation induce variation
- r1 g: a- _/ U$ V2 d! i* h+ O4 Z! H2011-12-10 09:36, s9 b% I* k/ l. {4 v' s7 c+ a
GVT will be cancer terminator， Cytokine storm will be cancer preventor6 S( H$ g9 e9 {9 D2 G# o3 P
2011-12-8 12:56
. e/ j. f; t* wcell fusion results regeneration，reprogramming，neogenesis，atavism； cell division results differentiation，apoptosis，senescense，development;0 i# ~8 d: f* ^  @; L) ?0 ~
2011-11-27 14:54
! @1 }- \% w, d% n7 W% Y8 pCancer is between protozoa and mesozoa， not metazoa...1 p0 x3 o, W9 c# D/ L1 H9 S$ a
2011-11-27 00:257 E' r/ [* ?4 {0 {8 F, w8 Y- \, B2 M
cancer is neurological disease！ haha，I got it！
9 `! d: j$ e6 Q! J2011-11-22 22:06
) |+ P% {( j+ a: @you are cancer，fetus is tumor. 佛曰：汝既是癌 癌胚如来
) v% S- Q5 p6 ]2011-11-12 11:27( n. {: Q/ e1 i* h/ b5 E
cancer is the ecological invasion of hacker...
% j2 \! I' p5 c+ r% E6 I; C3 h2011-10-5 10:311 H& L- I7 X6 L) z) o
microRNA is  negentropy？# Q+ V; |% a2 n+ H( J3 @* d; w
2011-9-24 00:48% {$ q( V+ k8 A: t
cancer is the social problem& M& y4 ?9 }8 }/ |9 h' p
2011-9-9 23:33: L( q% q+ P- Y3 [, u( m- Z& Z
Science is the games of nobleman or madman
! H2 g4 T- {7 Z1 r- f, [2 ^7 \, U# X2011-9-2 15:031 ~1 V( z5 ~% w, K! W
cancer resulted from disturbance of biological liquid crystalline state of ECM* J" y) C! N  J  y
2011-9-1 20:13
/ ?3 r$ c6 F/ w% `* ?0 Wniche n-dimensions——space, time, momentum and entropy; energy, material and information flows; physical, chemical and biological factors；topological, thermal, and fractal influences...- j8 G, s7 v( {8 [8 @% f
2011-8-13 00:37$ e9 Q' m$ L+ ?9 j6 y, Y; |/ c
Second recession is coming？+ w! A6 I1 g+ W) L& u, i
2011-8-9 23:58/ V" P& V3 o/ s3 g, F
cancer may be from sexual reproduction of somatic cells.' D! y  j# k4 S+ @# _9 Q( l$ J
2011-8-7 00:16- k- d0 {4 h8 G5 c/ y2 n# H  o# w  w
who determine gene？ genetic determinism is fatalism！5 U3 b& r* G0 F7 [4 A
2011-7-30 11:26
; _7 U9 o# o' ?6 I% ~+ w! fniche reprogrammabllity is the key of solving cancer problems...
9 }3 T" i1 F/ s1 W; G  Isongtianlong: i can't agree more!!!O(∩_∩)O~ (8-14 20:42)5 a/ ?0 a* {4 X' V
sunsong7: hehe. thanks for interested in this topic, welcome future discussing (8-14 20:54)
4 `3 c# n" }% L! x2011-7-24 01:24
  G' J8 r2 s. [& s* _, N; \+ D. e+ kcancer results from acquired genetics alterations.' Y' z6 r+ z5 X7 x2 e8 H6 m; N
2011-7-20 21:378 c3 T6 ~; Q4 I3 ]' S
CSCs are the low differentiated cancer cells in G0
; m3 z0 F0 O+ c; P5 E2011-6-29 16:30  t: U# |* A* ?) \1 W( z8 K
iPS future——in vivo direct reprogramming ...+ r( f: o8 h/ z
2011-5-31 15:20
0 S) _, A& i* N. o- i0 ?* L* ^niche reprogramming——cell fate will be manipulated by cytoplasm - microenvironment interaction http://www.stemcell8.cn/thread-40755-1-1.html1 a3 X& C- S! w% C( g! q
2011-5-31 01:28
4 i/ Y9 [: y1 i: R& s( Zall the somatic cells of Mammals are totipotent ！# c1 b- s6 F) ^8 R, l
2011-5-22 22:22
% T8 n$ P: V# l  w5 h5 NmiRNA——The manipulator of  cell fate！. f' E7 ]! U5 v8 B: I' ]
2011-5-20 20:21
+ k# v+ s0 G3 J/ v《Cell Stem Cell》means “cell is stem cell”   活细胞就是干细胞？
1 [* I' F4 m& v# j2011-5-17 12:38) {4 b$ I- a+ B: z# o7 q1 c2 @
cancer —— good nuclear in bad cytoplasm！RNAs are cytoplasmic determinants determine  cytoplasm determine cell fate！ division is differentiation is cancerous is life ！
4 y) d; ~+ m; s4 D9 r3 s2011-5-11 12:31
) V% l, x0 C* H9 Q% Q0 w: Ocancer results from cell dedifferentiation...: q' h% @' R' g; k' E0 T: n
2011-4-28 18:07
! b) t' g+ ~; [2 w+ K  ?differentiation——asymmetric cell division ！- `* P4 W/ f* n2 K9 O
2011-4-28 18:041 l+ |4 _/ m! F. K0 p
cancer origins from the regenerative cells！* p  i7 n: [7 ]( X
2011-4-28 17:52
1 ^/ c! T5 V/ y1 b# s- PProliferation is differentiation potentiality！
8 U' [. I, a' {2011-4-28 17:49
% K; b( P! V. }. g: Z' l9 b& ]iPS——the key of Pandora box！
2 n% {% o3 \: y; a( E9 g. B2011-4-27 22:36
: [& \* x( w, n, v( YAristotle— "The whole is greater than the sum of its parts."
+ W" r9 r& P% s% d# a; a' ?2011-4-27 00:20
1 j2 v  a* Y! o+ \' X. ?cancer——atavistic cells
# C# H6 s# i2 m+ _3 M( i9 o4 q2011-4-20 00:20
5 a( w1 Q2 W3 `; b( Dcancer——cellular atavism！# o% G: U) h  {  z0 c! b
2011-4-20 00:18
- l3 ]  }& [1 {6 `cancer——evolutionary ancestors of mammals.
) w! Y" v0 l9 a" z% ^$ J2011-4-20 00:09
) h/ O( S5 G- e肿瘤是细胞自组织缺陷的产物 ! V, z, f8 i, b& m$ P2 k  J9 [
2011-4-17 01:41
6 ~* `) q; ~' ~3 @% n/ b& w5 Icancer——Metazoa 1.0" d$ I5 A7 m! K! g8 B7 i% o# P
2011-4-17 01:00' y0 U! A: F  w! [. b& F
US——the Axis of Evil！
! Q$ U2 L8 H6 h) `8 X: p. P2011-4-4 01:19$ i: f! z- a" u. d: @
美国是世界的邪恶轴心！
" e! Q+ n+ U5 k) S, E+ Q# Rsunsong7: 沁园春.血               ---作者：萨达姆   日 本 风 光, 千 里 地 震, 万 里 海 啸。 望 仙 台 内 外, 废 墟 莽 莽； 东 京 上 下， 顿 时 逃 逃。 核 站 爆 炸， 世 界 惊 涛， 地 震 海 啸 试 比 高 ... (3-22 21:25)
- j9 b2 {. K7 c/ o  X) J# Z2011-3-22 19:06
( m; K+ n" {2 vteratoma is derived from endogenous iPS！
  p6 ]9 E& Q% D6 ]$ E2011-3-15 21:44
! x. P1 k- V' v. b1 p0 Jips is a luxury gambol on  % g* {; @- U7 m0 t$ v
2011-3-3 14:50
9 l, }2 q1 |+ q) R* V, `: ccancer is intermediate of species evolution
3 e- [: Q( j! i1 ~% J2011-2-12 12:29
# i# S8 ~/ `# q8 a% pstem cell now is on the eve of coming medical revolution' q: u5 X3 W6 i( O9 k2 N) P/ i# x
2011-2-12 11:208 G- p7 V7 ]0 Y$ }  [. V
Inflamation is the reprogramming process of somatic cell in vivo！
7 C/ c' _' @& ?" [3 L% p' k2011-1-31 14:498 e2 N2 [! y$ v
so-called medicine is niche regulator！1 m7 S  I+ ]3 r$ z* C6 V( c
2011-1-23 21:45) s+ C% d) i/ ?* |! [
endogenous iPS is the cancer initiating cell！1 ~7 O9 ~  D" k( z. \0 |4 Y+ i1 B
2011-1-17 16:47
9 Q" `: O& B+ {4 j0 p4 m7 v8 gcancer is unicellular organisms！& l/ q/ Q1 c6 \9 F6 B1 K
2011-1-9 22:04! e) [  i: d$ h. [9 Z- |
Pandorabox Has Been Opened8 ^  H3 h  |( \0 w- b. h0 f2 x
2011-1-7 23:243 A) t6 X- v3 ~& @* L
iPS is the Emperor's New Suit ! % f/ L; h" z9 `
2011-1-5 23:50% z2 e( k* m7 \. f& I
cell-free is the final solution of stem cell therapy
2 S2 @: o: w. g: r6 S7 |3 p$ c2011-1-5 21:46
6 m' b  E; J: |4 l2 U- S% \niche is telling the story of stem cell...
" E* R5 J/ d; ?5 A% ^2010-12-29 17:322 N6 N9 G, C; s5 V( N, X1 z
cancer results from reprogramming of somatic cells
$ s  G* {' @. h5 _6 [/ w; a9 P2010-12-25 18:56. T2 r7 I0 P2 O! s  e
cancer——good cells in bad niche！. o) L/ L2 }6 N. }
2010-12-25 16:02
! v# Y1 W! i6 H& X5 H! y* mcancer无罪——制造产生罪犯的土壤才是真正的犯罪！2 h, y% x$ V: b& ^
deron: 灰常同意，有相关文献么？ (12-19 09:41)
( a  Y) O0 M; G# f2 l- p( esunsong7: 呵呵，请来参加讨论——癌细胞的发生可能是一种“返祖”现象？ http://www.stemcell8.cn/thread-32073-1-1.html (12-19 11:33)5 o3 P: [6 r/ S% ?: [* k7 Q
sunsong7: 问题讨论 http://www.stemcell8.cn/forum-re ... 709-pid-246202.html (12-19 13:29)
- N8 v7 Y  V4 R* J2010-12-18 15:54
7 d- l: C' a5 y8 ^1 Q* k4 F8 E子曰：上善若水 大成若缺——干细胞治疗的终极解决方案将是不移植外源干细胞！+ T. f7 Z/ g8 q/ b1 a
2010-12-15 15:07/ S2 {' H! B3 M' G. [, Y4 {! e9 z
老狼的记忆——大洪水
3 q1 `3 ~/ k6 x+ Q; M* f* W2010-12-13 23:25
4 {2 w  T, G0 c- o: hcan cancer randomly differentiate into norml cell in vivo  
' M/ M5 i+ z$ `; X: R' v2010-12-13 22:339 O- W. X8 Z0 D1 E: n
omnis cellula e cellula9 X1 R( @9 j* D$ ]1 P
2010-12-12 09:28
- p4 t) I, t) N; X0 H: x6 XStem Cell ——The Origin of Disease7 j2 ?+ {: K! h2 G" H
2010-12-12 09:27! n* W& R. h8 Q* B