老狼的个人空间记录

sunsong7

"genetic mutation" should be exactly as "gene self-editing"
1 g" Q8 d! Q, X; B2017-12-1 13:17
: o4 s$ b! _1 D) _, S6 ]9 ?Bioreactor in vivo would be the terminator of illness.
8 ]# c4 z" }% V2017-11-20 23:09
, u% _  I; [3 Hrenew tech：剔除衰老（病变）细胞占位可以恢复青春。
; P7 l; k% R2 Z3 g0 C, U2017-10-23 12:50
6 E1 B# I) g6 L, y# |; P- t) |魔不疯，鬼不魅； 道非盗，仙非妖；神无形，兽无极。
' F' I1 F5 n1 n/ O( _; _% x* t2017-9-30 10:58
9 L* A+ `3 n4 [) g: B* B2 _) LLife 3.0——from decoding and coding to reading and writing
+ {( j: e8 v5 t$ }* q  F2017-9-21 22:32
( m7 M6 q9 h4 Z) j4 w4 q理论创新：亮明立场——先颠覆，再完善
/ m7 a0 T. U* _! t3 d: h. N2017-2-7 00:07
7 [6 j# ]2 `" t) ~+ e2 ^$ ^+ f干细胞第二定律：与细胞外基质共同构成多潜能；
$ y3 j% K2 X' R- R3 R4 w& ^2017-1-3 11:14
' K( ~' Q8 x" T+ B4 A& w干细胞第一定律：全生命周期保持增殖分化能力；
0 [, F" [0 i: a& b2017-1-3 11:13) |: z" V6 ]5 G: ?. Z' P
NgAgo——Never give A guideline operated！4 [6 k) |! X& X
2016-12-1 10:09+ H, j4 n; v& ?; {2 j8 n
表观遗传—— 一切皆可改变  一切皆有可能
% d5 p4 ~4 s6 `- o: a, T7 ]2016-8-17 23:37" s& V$ b/ O7 F  m! c
子曰：吸血鬼疗法——养儿防病 养孙防老
' m$ A' l0 c9 C7 g9 x; W2016-5-23 12:05. A, ^. m/ w# J4 d
NgAgo——Debug tool kit for mammal cells
$ @% W7 A% V9 s9 k6 I2016-5-9 13:098 }; F" m5 b( T! j9 l% ?' Z; z
公理之外 皆需证明； 科学命题 皆可证伪。5 t( w; m& b0 p9 M+ G& j- X: O
2016-1-2 00:20
; [9 `- Y; r, a: F# z' |低氧——破坏线粒体功能、诱发炎症、导致基因突变/ ]$ C- Z$ T" [) t& E3 z( T
2015-12-16 20:19" U: r- J* ?- {% C, x3 g8 o
癌症——炎症部位组织再生过程中细胞去分化失控形成的幼稚化新生物。
- p7 S: I7 Z" t: `1 chcoohboy: 一个有趣的假设~但是没有炎症就一定没有癌症吗？ (12-18 16:16)8 M/ l: K7 _+ L3 b& A: s, o3 t
sunsong7: 炎症与癌症同在，Hanahan D, Weinberg R A. Hallmarks of cancer: the next generation[J]. cell, 2011, 144(5): 646-674. (12-19 19:45)
( A) f- H3 L0 M7 {4 nhcoohboy: 3ks~ (12-24 16:45)
& {5 @0 M9 r6 f1 c! X  K8 d+ v2015-11-18 15:54
8 Q, W+ D- u3 p8 X( h2 |) V抽象世界与客观世界的真理判别标准是不同的： 在虚拟数学世界里，逻辑是一切命题的唯一审判标准； 在客观物质世界里，证伪是一切定律的最终审判依据。
* L! V- \$ a" m" a- q8 f2015-5-20 14:13) E/ k8 {+ q  ]# C) D% R
传统生物学将死：进化论=自然神论   基因轮=宿命论   细胞论=活力论翻版。    现代生物学曙光乍现：系统生物学=数学 结构生物学=物理学 合成生物学=工程学
1 x8 O7 t. O3 l8 }" phelong: 系统生物学是把细胞、基因、进化、物理学、信息学（数学）、工程学等都打包起来的所谓新学科，目前只做到了简单组合，还没有达到系统集成阶段。合成学更多偏向于化学。 (4-21 19:28)
7 W! a5 u& k4 {. C+ ssunsong7: 方向对头，努力总会有结果的 (4-21 20:05)
- r9 ~5 B, A( \6 @! P7 e2015-4-21 16:46
% d, g# F  F" V5 `# ^# `( C' Jsearch and research is just disassembling the creature.
- p& a( r, m: d; U" F/ T! l2015-4-7 17:01) ~" _; \+ J6 p9 b4 r
selection is  the act of intelligence% }4 z* |' u, O( S
2015-4-7 13:49
# E6 y  a" m: M/ q: M# ~, B* _Genome fusion create neoplasm$ a0 ~" e4 K# d, i: L! ]
2015-1-20 13:100 I: J( j. Y" `8 i- Q; s4 L8 |
STAP——Stupid Trick  Against Professional 
  a3 Z8 j( v( f$ x2 M2015-1-1 19:29. m8 N5 }- A1 a4 @, k# D
information=structure=negentropy8 D+ {) i; j+ K& X
2014-7-22 17:36/ m8 i# j; a$ t: ?
Natural mutation does not result in new functional genes 
2 c) A6 r) |* ^6 B. j& f2014-7-3 14:062 G. ^1 m  b6 Q
life is wisdom creation instead of natural evolution
( Z' H" C2 l" s3 z. Y$ d2014-3-27 09:33
3 M! P1 b3 M  O  _7 \. t% rlet us explore the source code of life !
; O6 W3 @2 \8 ?6 {9 X2014-3-11 13:113 G  U+ D0 ~0 E% e7 T
bio-manufacturing——processing，machining，casting，printing，3D prototyping，duplicating，cloning，life replicating.
. P) t% ]9 c6 f8 W2013-10-7 23:06
' s+ a/ f, J6 e8 |8 _2 M$ cinduced abortion would give the key for curing cancer 
" O1 E) H% a3 A' S& H2013-10-2 23:330 ]! t! [) F* [$ T
“key breakthrough” in molecular biology are entertainments
5 c' M, q; |9 P6 Z' i) _2013-6-16 11:50; b# ^! w2 I7 o/ B
Rules Of Living：trial-and-error exploring，survival takes the legitimacy
& M3 D" W' a$ B$ F( q; U- |2013-6-16 11:27
1 k1 Y+ h9 i8 z8 n3 Q* gLife is a set of debuging programs
! P* @+ Y! X9 q" N8 ?% b2013-6-15 18:407 p0 h( `# W9 N4 P/ ?
current biology is closed，destined and agnostic，it is  the only contribution is to kill cells
" ^) B& i  J* G9 z+ I/ M9 z2013-5-2 08:54% x- R; }' Q) L( W: }  M2 F0 s
information，energy and construction are the new base stone of biology，instead of evolution，gene and  cell  tales6 E$ k( \' }$ E' P
2013-5-2 00:51
7 y. h1 }6 k6 S# Evirus is the messager of  the universal life network
$ g0 v- E. u6 b0 O6 O( @+ }2013-4-18 14:33; @2 E( b/ w( V# f( t
Genetic information doesn't improve cancer risk prediction
- \0 ~2 O9 X' b+ x# ]  b# S2013-4-1 09:20
2 s$ L' U: n( V6 VThere is no early diagnosis of cancer，but early prevention of it
! J# V# d: C' [2013-3-27 09:17& S, A; ^2 n: N
hypoxia maintains stemness or carcinogenicity
, @5 r0 k2 ~  z! c1 J3 z: _2013-1-2 05:21' a8 q; e& Q7 I3 S
cancer is the living fossil records on origin and evolution of human being+ M- e$ x, P$ z. K) a( a9 o/ @: m  ]
2012-12-9 23:31
" g) N% O0 E+ D+ Z; M- ^% pinformation island results cancer
. F  ?8 r1 d/ v2012-12-9 05:23& ]' N. {2 X- D; p' B
life is digital game
1 t) Y) V* I; r" ?* o: O% A2012-11-10 00:174 L/ y1 }( s8 H
cancer ——severe abstinence reaction of cells to niche addiction3 ]4 }  s- k+ g/ i8 u2 }( a
2012-9-28 12:11
. D& i* l2 P0 R2 W1 i未来生物学终将回归物理(熵)及数学(分形)的美感5 [% S  I8 ]1 @" V4 X
biomater: 熵理论适用于任务物质。。。。也适合于生命 (9-26 09:28)
/ u; H$ m" _9 T- Z& H9 [4 T; y/ q2012-9-25 21:22" }& b7 a; h  }* j' ~
membrane holds the key to life* k( J- V# }& m+ m$ [% ~
2012-8-19 20:24
5 [) P9 z$ j: t3 p# vCancer is the default state of cells6 e  Q" o3 p# |. l; r* w* Q
2012-6-26 22:170 J6 I9 c0 |/ `2 W; d( \
mainstream cancer theories could be overthrown！! k9 n5 \1 |- e% v5 G# s
2012-6-25 15:435 t4 }: H8 I" \! |
carcinogenesis has nothing to do with the gene mutations but is  the result of niche reprogramming...
6 E+ Y- U6 S* T2012-6-7 09:36
& I$ I" W! H3 p% C5 a" t4 I' x% Oevery living organism connected with the water， one cell one world- Q7 n4 |2 B& Z$ w" \; g
2012-4-19 22:06
2 Q0 \" z5 Y9 P" h) E1 |' a$ Schemical structure of cancer cell determines it's biological function...5 n- Q8 x8 R7 h* Y1 ~
2012-4-7 17:56
" O! d0 b8 h9 w0 e' lMann tracht und Gott lacht$ u9 R% _% [6 ~4 B0 x& }* W
2012-3-24 21:34
; r/ [4 r% Y* ~( G; ?& s  g7 zDarwinism or genetic determinism is a fairy tale！7 g7 r% }: E: F8 K& @
2012-3-13 15:18
& ^  j0 u% P: A9 Fniche isolation is essential for cancer speciation  r9 @! I% V8 d! [6 Y
2012-3-12 12:07
% ]/ V- u, a  \" D) P" PHybridization Creates New Species，Mutation results species extinction- l2 k$ h0 [% t# m5 C
2012-3-11 18:213 R) K& h! D/ R
ROCK may join the niche reprogramming...
# |8 a8 a+ M$ I$ fyuhaoze: 这是篇文献吗？ (3-9 10:41). R8 g4 c- `- M! |8 h
sunsong7: http://www.stemcell8.cn/home-space-uid-6268-do-blog-id-1211.html 突破：病人体细胞及肿瘤细胞长期体外培养（附原文） http://www.stemcell8.cn/thread-51419-1-1.html (3-9 10:46)
8 i! d7 K' h. l$ dyuhaoze: 啊， 我看过这篇，还顶了呢，谢谢哈 (3-9 14:37)* ^+ D2 @0 M2 D+ e/ c/ x7 ~
2012-1-19 10:52
: J2 W/ s& A- P( }) doncogenes are pseudoscience
9 C! x: B+ c$ r2011-12-29 13:55
) F  f" y* W0 f  _  E% f# Jgene mutation leads to variation or extinction, not new species
! Y7 v3 Q% V5 G' J( G; [/ G3 Q* W2011-12-29 13:287 \8 ^3 {& [6 h
oncogenesis is non-Darwinian event3 y2 C4 P! c, O! H  _. \% @/ I" z8 I
2011-12-28 22:56
3 v$ J  E* E% u4 y0 ~disorganization activate neurogenesis activate oncogenesis     i1 Q( Z& u2 {) t; a6 _
2011-12-22 23:38' \, P( |7 J" l; o6 U& `7 H6 V
MSC is cell feeder，tissue scaffold，immune firewall and biological glue- k5 A$ O# H+ y) }( U: d# ^) _
2011-12-19 19:46* c% _; w$ M) T
cancer is Noah's Ark（species carrier and life explorer）
( c6 Z- e( F) X2 d2011-12-10 09:46
# H0 P  ^3 A; t+ m) }7 E/ Ccell fusion create new species, gene mutation induce variation6 z# N" s; p# L; c4 G
2011-12-10 09:36! ~! y2 C2 M" E% T  z
GVT will be cancer terminator， Cytokine storm will be cancer preventor
- t) Z" m/ p* G* W. G, w1 f; t+ t2011-12-8 12:56
, ?4 l5 `$ p0 H, K1 h! T0 H7 s( B6 Ycell fusion results regeneration，reprogramming，neogenesis，atavism； cell division results differentiation，apoptosis，senescense，development;- G/ B( F6 ~* {5 l/ h
2011-11-27 14:54
) B3 b" p2 N+ W' p  U1 iCancer is between protozoa and mesozoa， not metazoa...
" y0 n) a# b2 g4 h2011-11-27 00:25/ l( }) z4 ]! J8 T5 Y
cancer is neurological disease！ haha，I got it！8 s$ F3 }. a% B; @
2011-11-22 22:06& _2 V0 t6 |* v! ~9 ]2 E$ B
you are cancer，fetus is tumor. 佛曰：汝既是癌 癌胚如来
6 s7 a) b  d' J! X: Z9 S" F( ~2011-11-12 11:27
# ]( H: u/ m4 ^cancer is the ecological invasion of hacker...( D. V% U+ D& x  `& n
2011-10-5 10:311 v: Y! B1 L; L( [  S
microRNA is  negentropy？
( a2 a0 K6 L  f2 g7 q' P5 L2011-9-24 00:48
' D- x. n2 B# B4 rcancer is the social problem6 t1 Z' D  o) H2 q2 ?
2011-9-9 23:33
' h) F! P  D' v+ ~( Y4 AScience is the games of nobleman or madman
- I' A8 K+ |: J  B$ m  f8 e, ]2011-9-2 15:03
- y2 c# j: u* Rcancer resulted from disturbance of biological liquid crystalline state of ECM- P' T1 O* i8 D3 c
2011-9-1 20:13  I% N  r* z7 d- M3 F+ Y
niche n-dimensions——space, time, momentum and entropy; energy, material and information flows; physical, chemical and biological factors；topological, thermal, and fractal influences...
1 R0 q) E9 y2 Q+ N, ~# t; X& f2011-8-13 00:37
' Q  g/ X- B6 Y% r/ c9 W2 e$ G! |7 USecond recession is coming？
# {7 j- F6 I+ s  k2011-8-9 23:586 _: H( I) d4 i0 B8 ?3 X
cancer may be from sexual reproduction of somatic cells.
! N* g' t$ e& {- `/ g3 L2011-8-7 00:169 y7 R6 k/ a/ D$ N2 b8 M
who determine gene？ genetic determinism is fatalism！
8 _) A7 j; }& D1 E2011-7-30 11:26
/ F! v; E- L2 _4 |- \& O7 Zniche reprogrammabllity is the key of solving cancer problems...
# {( s& b$ \( O) X+ Lsongtianlong: i can't agree more!!!O(∩_∩)O~ (8-14 20:42)
; t. U, \3 j* q% M3 Nsunsong7: hehe. thanks for interested in this topic, welcome future discussing (8-14 20:54), V8 k4 U0 L% r  w
2011-7-24 01:24
8 m$ h1 w; y5 G1 v5 ]& l0 Q% \cancer results from acquired genetics alterations.
$ n3 l2 H; s0 f& \; B: u2011-7-20 21:37
1 Y5 \3 D7 d& j- x# L" U' P* ACSCs are the low differentiated cancer cells in G0% H' |3 |4 V* D, K, ]6 }
2011-6-29 16:303 E5 D  [% i! {; }9 _; q
iPS future——in vivo direct reprogramming ...
! p& A# z& q1 r2011-5-31 15:20! @% R; i4 O& y& I- ]( Q! B- B
niche reprogramming——cell fate will be manipulated by cytoplasm - microenvironment interaction http://www.stemcell8.cn/thread-40755-1-1.html. T1 N0 W* |2 \2 }6 s" T
2011-5-31 01:28% g+ o+ d1 i. P+ s% l4 p4 \
all the somatic cells of Mammals are totipotent ！- p, {3 W/ v# H% \) F
2011-5-22 22:22
4 p1 `1 h7 d+ amiRNA——The manipulator of  cell fate！. F. k1 r; N9 N) C/ @, t
2011-5-20 20:21  P3 v* B8 _' r4 M9 L
《Cell Stem Cell》means “cell is stem cell”   活细胞就是干细胞？
6 V- X0 [* r  t: ^. ]1 x1 M2011-5-17 12:383 e0 F6 x4 V5 B7 @4 Y# o
cancer —— good nuclear in bad cytoplasm！RNAs are cytoplasmic determinants determine  cytoplasm determine cell fate！ division is differentiation is cancerous is life ！7 q, c5 M, t! f  o7 F6 v* ?
2011-5-11 12:31
4 w1 q! F2 e3 p1 L6 {cancer results from cell dedifferentiation...2 C3 }9 q! H# b0 Y
2011-4-28 18:07) F, V: ?* u, x& U/ Q
differentiation——asymmetric cell division ！
# }& @& ?8 y! _. R. Y2011-4-28 18:04
0 Y/ J( _$ A' R3 m2 z! u% Icancer origins from the regenerative cells！) X- _; ?( f5 k: X0 B4 j
2011-4-28 17:52
' r4 i' u6 B$ c4 M  j; I, J7 WProliferation is differentiation potentiality！
& ]" ~3 a- m6 _; Y, Q* S: n& b2011-4-28 17:49
5 c' Q& O0 L9 b4 [" [. _% \iPS——the key of Pandora box！
2 Q# c. B6 Q+ u8 P" w2011-4-27 22:36
4 @6 y) [# t6 y+ z1 }2 k' P  gAristotle— "The whole is greater than the sum of its parts."
( N7 c9 g% Q* u" n2011-4-27 00:20# Z1 v' i% @7 P1 b1 q1 `& J
cancer——atavistic cells$ z4 s9 y: R+ C( [( v/ p
2011-4-20 00:20
$ e8 i* X6 w6 U6 R" h1 T$ Jcancer——cellular atavism！
) W' i3 g( E/ i2011-4-20 00:18
$ |4 n. J, F( o: rcancer——evolutionary ancestors of mammals.
* u8 h; l4 u. |2011-4-20 00:09& a, T1 b" Z6 n- ^
肿瘤是细胞自组织缺陷的产物 6 U& p- D- n+ p  |+ G9 T
2011-4-17 01:41
5 i8 ?' n7 ~8 m1 Rcancer——Metazoa 1.0
! }/ j$ ^$ O9 K& M( f8 @2011-4-17 01:00$ |% y% I9 f6 s8 p
US——the Axis of Evil！# `' @- {' e0 R1 [" [# _, @
2011-4-4 01:19
/ C1 n! q2 W' E1 b$ u# ]0 B2 Z% T美国是世界的邪恶轴心！
" X6 j3 b5 j, i9 H- Q' Vsunsong7: 沁园春.血               ---作者：萨达姆   日 本 风 光, 千 里 地 震, 万 里 海 啸。 望 仙 台 内 外, 废 墟 莽 莽； 东 京 上 下， 顿 时 逃 逃。 核 站 爆 炸， 世 界 惊 涛， 地 震 海 啸 试 比 高 ... (3-22 21:25)1 v  |  I$ z8 m" P- O
2011-3-22 19:06; J: {/ F4 ]7 S1 h: [% H% L4 ^
teratoma is derived from endogenous iPS！% T* J/ F  R2 f3 x% k3 L8 R
2011-3-15 21:44
; ?, o0 I2 h! pips is a luxury gambol on  
, q) k7 r4 Z4 F2011-3-3 14:503 L& h* T# p6 t3 M! x- K+ \# [
cancer is intermediate of species evolution) Q1 Y2 D4 U$ D, x
2011-2-12 12:29% n  v, Y: H6 X/ I/ J9 \
stem cell now is on the eve of coming medical revolution* D% J6 {' l' z0 r6 k
2011-2-12 11:200 w9 L2 J  {8 D+ E9 _2 r# g
Inflamation is the reprogramming process of somatic cell in vivo！$ B& J4 [0 w) ]. u, C
2011-1-31 14:495 a# B* @! k: Z% Y
so-called medicine is niche regulator！/ T) d( [: E& J6 ?
2011-1-23 21:45
: z. {- v8 T# s5 V2 b/ C- Y# Mendogenous iPS is the cancer initiating cell！
+ c' a1 @" Q9 }  I2011-1-17 16:47' g/ n& |) K1 a& c8 {3 S* k
cancer is unicellular organisms！
- B3 }% f  _: W% a' S7 ^2 c$ n! O2011-1-9 22:04
7 G3 J  e) q7 e/ S4 O+ b2 Y' ?1 wPandorabox Has Been Opened, Y8 f, M/ Z( A# t$ U: `) i
2011-1-7 23:24
: e- V, m. _$ u7 uiPS is the Emperor's New Suit ! ) T. s& u$ |: c/ }4 d( T" v3 U
2011-1-5 23:50
5 A; K9 _: T4 {. e+ D0 Ocell-free is the final solution of stem cell therapy9 Z- K+ ~) @. m  K
2011-1-5 21:46+ K. ~8 S2 o9 T6 A( ?
niche is telling the story of stem cell...
, \5 ~% G/ V6 a  N- o2010-12-29 17:320 a+ D3 _9 l8 b1 k
cancer results from reprogramming of somatic cells4 I. w" X4 w' Q! E% V& N' z. U
2010-12-25 18:560 `/ r( Q$ J2 k/ d- y
cancer——good cells in bad niche！3 t" Q, ^" x4 y- ^0 a
2010-12-25 16:02
) ^( |+ t; t4 W' w# g. J" P2 d2 @# vcancer无罪——制造产生罪犯的土壤才是真正的犯罪！
! F% ?, I( R$ D) j& o$ z2 Rderon: 灰常同意，有相关文献么？ (12-19 09:41)8 K5 z9 ]1 c6 R! ^
sunsong7: 呵呵，请来参加讨论——癌细胞的发生可能是一种“返祖”现象？ http://www.stemcell8.cn/thread-32073-1-1.html (12-19 11:33)
5 L# V  a% |& u' |. `6 x. Jsunsong7: 问题讨论 http://www.stemcell8.cn/forum-re ... 709-pid-246202.html (12-19 13:29)
% Q: n' v+ Q- t; l) Q) N4 K2010-12-18 15:546 a- o- M. u8 p
子曰：上善若水 大成若缺——干细胞治疗的终极解决方案将是不移植外源干细胞！
, w+ u) ?7 y! z* ], T2010-12-15 15:07
4 ~+ C, s: x' d( q3 [; @老狼的记忆——大洪水
6 Q( J: k/ k/ i1 W: K4 f2010-12-13 23:25
; j" N# N5 z4 S3 c  E' Kcan cancer randomly differentiate into norml cell in vivo  
  p; ^% e0 k* D9 O3 v1 t- ]7 {2010-12-13 22:33- m+ A0 l* N2 n- u5 Q2 R$ b3 c
omnis cellula e cellula
4 q4 ]: i5 @. t  R; Z2010-12-12 09:28& a# J9 B' L% u5 _. p, V- u( R, {3 ?
Stem Cell ——The Origin of Disease3 h! L& t2 \$ }4 p) t6 o3 X) u# r( x
2010-12-12 09:27& T1 K- c2 z. Y* O+ J. O! a2 i7 l

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