老狼的个人空间记录

sunsong7

"genetic mutation" should be exactly as "gene self-editing"$ t+ L' X" {* E  U, A) p
2017-12-1 13:17
& `5 Y0 |; ?  d$ z. m9 mBioreactor in vivo would be the terminator of illness.
4 Y: R. }: n0 O4 D; _. S; B% [; K% m2017-11-20 23:09
4 ?' b3 N  c2 k8 }) ?6 C' d6 Grenew tech：剔除衰老（病变）细胞占位可以恢复青春。# o# P& N" j7 K/ D7 R, }, ~
2017-10-23 12:50
4 O. G: `9 E! N魔不疯，鬼不魅； 道非盗，仙非妖；神无形，兽无极。
6 l; U3 p$ r% l# D% X2017-9-30 10:58, N: S* b/ @7 t7 m  ~! u3 ?% J/ V* G
Life 3.0——from decoding and coding to reading and writing
- H$ d9 p% d6 z/ p, ?4 u; b2017-9-21 22:32
% @2 Q. J1 \& T5 O& w5 Q- ~$ Q( `, L' l理论创新：亮明立场——先颠覆，再完善
% }& r4 S* v( j) W2017-2-7 00:07
, J& I( V8 b( a6 A# f干细胞第二定律：与细胞外基质共同构成多潜能；1 ]5 z1 X: ?4 f
2017-1-3 11:140 J  Q& `  ~5 s3 V: P$ t- t0 e
干细胞第一定律：全生命周期保持增殖分化能力；
! H6 l+ ^7 q# e8 H" q0 R2017-1-3 11:13
4 y% v' ^9 ?1 y0 INgAgo——Never give A guideline operated！
& Z9 L2 U  z* Z7 \3 h( i& q: T2016-12-1 10:09# B) V: z3 c( C
表观遗传—— 一切皆可改变  一切皆有可能/ B, f/ ]) C5 M' V$ u3 L8 `
2016-8-17 23:376 k4 l$ G2 U6 o  n6 t" X: T$ \
子曰：吸血鬼疗法——养儿防病 养孙防老8 f2 _6 A/ `. ^( @1 k
2016-5-23 12:059 o$ U2 T1 q  w( I( z1 c
NgAgo——Debug tool kit for mammal cells
3 T, f  i  j& s' k5 i" u8 J2016-5-9 13:09
! P" T( w6 J( t: O公理之外 皆需证明； 科学命题 皆可证伪。2 x# O0 C( r+ E; s+ n
2016-1-2 00:200 v1 \0 F4 `! v# T# ]0 _+ o
低氧——破坏线粒体功能、诱发炎症、导致基因突变" W  @  R. {+ x& E& b. \: E
2015-12-16 20:197 W, Q5 u" b$ u3 B
癌症——炎症部位组织再生过程中细胞去分化失控形成的幼稚化新生物。/ X# C2 w8 d% _
hcoohboy: 一个有趣的假设~但是没有炎症就一定没有癌症吗？ (12-18 16:16)
8 [/ M! h& B6 e5 Z$ ~* psunsong7: 炎症与癌症同在，Hanahan D, Weinberg R A. Hallmarks of cancer: the next generation[J]. cell, 2011, 144(5): 646-674. (12-19 19:45)& {2 ~! Z3 _8 @# {5 ]& l
hcoohboy: 3ks~ (12-24 16:45)" u+ w5 s: _* v/ m, y9 k( j. u
2015-11-18 15:544 Z5 {; A7 n! J  Y" ]" i
抽象世界与客观世界的真理判别标准是不同的： 在虚拟数学世界里，逻辑是一切命题的唯一审判标准； 在客观物质世界里，证伪是一切定律的最终审判依据。% y( m4 ?7 O& U) Z  x
2015-5-20 14:13
* \7 Q6 m0 A9 ~' t% n 传统生物学将死：进化论=自然神论   基因轮=宿命论   细胞论=活力论翻版。    现代生物学曙光乍现：系统生物学=数学 结构生物学=物理学 合成生物学=工程学, |% k9 o, K4 y
helong: 系统生物学是把细胞、基因、进化、物理学、信息学（数学）、工程学等都打包起来的所谓新学科，目前只做到了简单组合，还没有达到系统集成阶段。合成学更多偏向于化学。 (4-21 19:28)3 P9 ?) ~, J/ Z) X* V; h
sunsong7: 方向对头，努力总会有结果的 (4-21 20:05)* S8 f8 i4 I6 u  d0 U% o' O
2015-4-21 16:46# X3 u2 o: h- @+ n, S0 j
search and research is just disassembling the creature.1 ~: P1 e7 V: ^0 @% g
2015-4-7 17:01' o+ G" L* N, n2 X4 O  |, g/ v
selection is  the act of intelligence
& H- y' {% }8 r1 ^: V2015-4-7 13:49
4 Z7 b5 |5 i- h6 e3 n2 J  xGenome fusion create neoplasm% s. m' A9 ?# X) ]* w
2015-1-20 13:10) f2 u' s9 L& q
STAP——Stupid Trick  Against Professional 
% J' T3 i/ ?9 j% p" R* n9 t2015-1-1 19:29
, h. |: ~* b/ r" c$ Vinformation=structure=negentropy1 b" ]1 w* _) l' ~* c
2014-7-22 17:363 ~& x/ V7 Z# |$ ~3 i
Natural mutation does not result in new functional genes 
" j. w; Y# A) F# S2014-7-3 14:06- T# K, n% p; {0 ]
life is wisdom creation instead of natural evolution7 ~& J2 F3 g. D8 q  r7 ~
2014-3-27 09:334 Q$ G8 G! X+ v. k3 j1 X
let us explore the source code of life !
1 c( d, c( z- E* \/ b$ x2014-3-11 13:11: ^4 g8 T; k1 _; g5 p1 \
bio-manufacturing——processing，machining，casting，printing，3D prototyping，duplicating，cloning，life replicating.( P% s% P. o9 Q8 Z
2013-10-7 23:06; I* Z5 ?" i) b6 o
induced abortion would give the key for curing cancer 
) Y( W' q- L! A. [* [8 [2013-10-2 23:338 `' c& j  ^0 m0 L  f
“key breakthrough” in molecular biology are entertainments& }/ N5 ?. ]; Q. q
2013-6-16 11:50
  S9 m. P* ], g  wRules Of Living：trial-and-error exploring，survival takes the legitimacy4 C. C6 M! D' @1 m" J% g( A
2013-6-16 11:278 m: W& O$ Y* A# P" r8 @
Life is a set of debuging programs
$ T! F1 t* {: `5 i2 ]4 N2013-6-15 18:40
* d, Q( N" a( T7 Wcurrent biology is closed，destined and agnostic，it is  the only contribution is to kill cells
( u) B4 K2 y$ c7 d: ?$ ^2013-5-2 08:54
* d+ u* [. O0 t, |$ E% oinformation，energy and construction are the new base stone of biology，instead of evolution，gene and  cell  tales
1 [# `/ Y4 r* @7 e2013-5-2 00:51
* c: B( K7 f8 c3 K& V& x% Bvirus is the messager of  the universal life network0 M: N; f- L7 B& t
2013-4-18 14:33
5 a) D6 D( |& i9 HGenetic information doesn't improve cancer risk prediction
0 {" ~0 e: N( r: M6 p2013-4-1 09:20
; \: m6 |5 X2 Z+ j9 U( H" ^There is no early diagnosis of cancer，but early prevention of it
% |* x9 r! @" ^% {  b2013-3-27 09:17
$ ~6 y6 \, l1 P" j1 v  j1 Thypoxia maintains stemness or carcinogenicity+ a+ N0 Z1 {: t3 v, d
2013-1-2 05:21( R1 r8 o: U# G% L& N, j
cancer is the living fossil records on origin and evolution of human being
. C" |# A9 R* |5 z2012-12-9 23:31" X; f6 @, ?( Z5 _
information island results cancer
; d: H& q8 ?4 D$ ?7 ~2012-12-9 05:239 p* e4 k8 F- ?% G
life is digital game- Z6 P  ^% v. w7 N( A6 X
2012-11-10 00:17
* a! L, b' p7 P" Lcancer ——severe abstinence reaction of cells to niche addiction5 U! B$ M1 K9 k0 x$ T4 t
2012-9-28 12:11
' O! V' m3 d+ `  Q) w0 E未来生物学终将回归物理(熵)及数学(分形)的美感; I4 ]3 ~. q( }( i
biomater: 熵理论适用于任务物质。。。。也适合于生命 (9-26 09:28)6 }. O: Z0 o  B, R- _) U' W& z0 E& ^
2012-9-25 21:223 t3 t, _% V% n, `- t# c
membrane holds the key to life: g: s- N% P! v. a6 M
2012-8-19 20:24
( e4 t( f( _1 e% e$ v  D' @  \6 GCancer is the default state of cells
0 d+ \) j; _" o' R. S) p2012-6-26 22:17
9 L; m+ f' d) Kmainstream cancer theories could be overthrown！5 S! E, b  M3 i7 g
2012-6-25 15:43  j* }" K0 I8 w. W
carcinogenesis has nothing to do with the gene mutations but is  the result of niche reprogramming...# u# T% E: ~$ g3 H& ^: ~1 l7 c
2012-6-7 09:36
1 `" ^( A# U5 V) }every living organism connected with the water， one cell one world6 J& G- m+ W# s& ?
2012-4-19 22:06- j1 q' T+ z0 E# k0 u
chemical structure of cancer cell determines it's biological function...
1 z' e  `4 h  d/ s- j; Q: O1 u! Z) M- s, q2012-4-7 17:569 L$ Y8 [6 R% m# f& s, ^# Z& t
Mann tracht und Gott lacht3 |6 s' T* c+ N" o* k* j$ X/ W
2012-3-24 21:34
" K  `$ E; p, o6 g, g9 bDarwinism or genetic determinism is a fairy tale！, R$ d9 V, V: y8 ^
2012-3-13 15:18
" l! A( b. L4 Mniche isolation is essential for cancer speciation
. u8 H, p" ~% C9 m/ I* K2 y2012-3-12 12:07
$ _  z8 T5 F7 C6 E, RHybridization Creates New Species，Mutation results species extinction( I0 w, a4 L, q8 K& q& A# J
2012-3-11 18:21
" y( z) o( ?/ v, c  b$ GROCK may join the niche reprogramming...
$ X2 b5 |" q' \yuhaoze: 这是篇文献吗？ (3-9 10:41)4 J; S* x; D# Y5 f5 s' X5 C
sunsong7: http://www.stemcell8.cn/home-space-uid-6268-do-blog-id-1211.html 突破：病人体细胞及肿瘤细胞长期体外培养（附原文） http://www.stemcell8.cn/thread-51419-1-1.html (3-9 10:46)3 l6 _1 y( B* }. k# G* [6 ?
yuhaoze: 啊， 我看过这篇，还顶了呢，谢谢哈 (3-9 14:37)- T$ k) v- d! G5 X; _, d
2012-1-19 10:524 I7 C& Y; f. t0 q+ _0 _0 `
oncogenes are pseudoscience2 K7 w' e' n  o$ E7 ^0 ?7 R
2011-12-29 13:55: {& V9 x% V; Y. r8 }  X
gene mutation leads to variation or extinction, not new species8 \# L0 Z1 Z  _2 {2 x5 z
2011-12-29 13:281 e5 n9 }% J. ^7 z& u* q2 V
oncogenesis is non-Darwinian event
9 a5 a  w2 g( a: y. p4 l- B1 @2011-12-28 22:56
2 t* x0 L6 C; v1 }) b; G& @) B  B4 h/ Vdisorganization activate neurogenesis activate oncogenesis   
  I8 w; D4 Z6 @" c2 y5 @2011-12-22 23:38
) S, L, ?. _9 @, a% G' bMSC is cell feeder，tissue scaffold，immune firewall and biological glue8 z' s; d7 b  f
2011-12-19 19:46" o- l0 O+ Z" f+ J, q
cancer is Noah's Ark（species carrier and life explorer）$ b) m8 I1 v- L4 P& Z3 R0 d
2011-12-10 09:46
; P+ }$ _. L1 q( _cell fusion create new species, gene mutation induce variation
! r; D: `7 Y9 Z: T- [2011-12-10 09:362 i9 r+ H' y+ n- ]! c
GVT will be cancer terminator， Cytokine storm will be cancer preventor6 g( w( l8 J/ Z$ z" `  Q" m; E
2011-12-8 12:568 a$ \7 y! k- J- R' `' T% J: W0 T' i6 v
cell fusion results regeneration，reprogramming，neogenesis，atavism； cell division results differentiation，apoptosis，senescense，development;$ U; o3 m* J8 Q$ @8 i
2011-11-27 14:54
  ]0 t8 {9 k$ e* K3 G3 U+ _Cancer is between protozoa and mesozoa， not metazoa...
* R4 D9 R: F: I/ ?  [' P0 j2011-11-27 00:253 M/ q4 {  w* k8 f) ~
cancer is neurological disease！ haha，I got it！
  e3 a# _0 o; m* R. O: [" o2011-11-22 22:06
# ?' S  `* A& U0 |/ |you are cancer，fetus is tumor. 佛曰：汝既是癌 癌胚如来4 ^, v; J6 q4 H- Y0 R
2011-11-12 11:27
, T3 j, l2 T' M% e2 D! z- B7 [cancer is the ecological invasion of hacker...
  L% J* r0 `4 x" c2011-10-5 10:31
) m% C* |! K8 Y6 X1 G2 U) TmicroRNA is  negentropy？
: n, k0 b& b1 m2011-9-24 00:48
. t. b$ x9 @. C9 h1 mcancer is the social problem: n4 z4 r  p) K6 x6 A, |
2011-9-9 23:330 z( i2 j) c9 }
Science is the games of nobleman or madman
: X! v) ], M) R2011-9-2 15:03
  ]# s" O, y1 Y1 ~2 g: U+ H- f! @* Mcancer resulted from disturbance of biological liquid crystalline state of ECM
2 b1 ~/ e/ d( X4 ^, }9 m, Z1 a5 V2011-9-1 20:13
! w1 o# h) T  y% W% G4 V4 m/ Xniche n-dimensions——space, time, momentum and entropy; energy, material and information flows; physical, chemical and biological factors；topological, thermal, and fractal influences...3 H3 {+ U" `: Q" P  J- y1 b# r
2011-8-13 00:37) S# e  M  P6 j6 W" d& M
Second recession is coming？0 ~) Q- R9 z) ~0 N
2011-8-9 23:58
2 U: a3 `/ P2 t/ S/ E6 Rcancer may be from sexual reproduction of somatic cells.3 Q- `1 H, v' ]
2011-8-7 00:16
2 t1 x8 ^. _2 Owho determine gene？ genetic determinism is fatalism！3 i. _( w& n  e" I
2011-7-30 11:26
  e$ |# Q# F# Jniche reprogrammabllity is the key of solving cancer problems...
8 F" N0 n" ]/ h; P; q4 Gsongtianlong: i can't agree more!!!O(∩_∩)O~ (8-14 20:42)( `8 u, V; \0 O! l( F3 J1 U
sunsong7: hehe. thanks for interested in this topic, welcome future discussing (8-14 20:54)- S/ r# n6 C& ]
2011-7-24 01:249 K$ B; L& q1 D8 N9 R
cancer results from acquired genetics alterations.
2 d( O( m; t" O4 @! s& Q- Q2 b4 Z2011-7-20 21:37
) ?) U' T% ~7 g! U* A: F" q- TCSCs are the low differentiated cancer cells in G0( |& J4 J( ~/ K/ Y* e
2011-6-29 16:30) @, K) w7 u! x& T* g- D2 U- Q( N" _
iPS future——in vivo direct reprogramming ...
( u6 S  C- P5 t5 A4 h1 D! X) i2011-5-31 15:205 ^% @' C- q7 p, y* I5 r/ ~
niche reprogramming——cell fate will be manipulated by cytoplasm - microenvironment interaction http://www.stemcell8.cn/thread-40755-1-1.html
' k7 C2 o1 g# m, O3 e! Y! j2011-5-31 01:28, ]' `" L8 w1 y+ S3 s2 k
all the somatic cells of Mammals are totipotent ！
+ `) x) ]1 I* {6 i2011-5-22 22:22
6 N" ~6 i3 }# Q8 v0 r  g2 H7 q, bmiRNA——The manipulator of  cell fate！
. M) k1 D. m5 z$ i9 J" s2011-5-20 20:21
. b$ [$ _6 v% B, X- q. T《Cell Stem Cell》means “cell is stem cell”   活细胞就是干细胞？1 Z7 C4 P( ^% u( `: c+ E/ ?! b$ A5 l' K
2011-5-17 12:38
. I2 G! i$ s; e1 Hcancer —— good nuclear in bad cytoplasm！RNAs are cytoplasmic determinants determine  cytoplasm determine cell fate！ division is differentiation is cancerous is life ！# C' E2 x) e: q. \
2011-5-11 12:31
% B! i8 ]1 g( s3 o+ Z/ acancer results from cell dedifferentiation...  E+ @* |, F/ j! u5 g
2011-4-28 18:07
2 v& M( X4 A+ H& K% pdifferentiation——asymmetric cell division ！6 W7 ]/ t) o9 g& b/ y
2011-4-28 18:041 m% D! ?' C$ y/ H7 _: Y$ E
cancer origins from the regenerative cells！) y- `0 t- k! F& j% w% [( {. z
2011-4-28 17:529 m5 T/ [1 V. J* X
Proliferation is differentiation potentiality！' R& O1 r- g6 Q
2011-4-28 17:49
; a# l4 Y  T! Z& O0 f/ @9 OiPS——the key of Pandora box！
6 f1 h7 W* ?: @8 l$ G( ?) z; P) U. l2011-4-27 22:36
1 f5 ~/ V2 L- H4 a  h! v" SAristotle— "The whole is greater than the sum of its parts."  _4 m" P/ L' l
2011-4-27 00:20
  Y2 B6 a0 `, f7 m  j2 Wcancer——atavistic cells0 V. B7 F: i. C% j
2011-4-20 00:20
3 S& j0 G1 x5 ^  N5 d: h0 m/ [% acancer——cellular atavism！
  v& C* R% j; ^/ N! M+ W: V2011-4-20 00:189 O- w) m+ O3 ~- i9 q$ I4 E
cancer——evolutionary ancestors of mammals.0 ?# z- R: b9 j$ q$ D3 z9 ^
2011-4-20 00:099 w5 M# h: i5 I7 k3 _; S+ d) H- y/ k
肿瘤是细胞自组织缺陷的产物 9 O0 p* d+ n0 g4 Z+ ]. i
2011-4-17 01:412 H' K9 e- Q1 j3 y
cancer——Metazoa 1.0
  M* N/ C! Z0 ]' z2011-4-17 01:00
0 j3 ~5 G$ P0 d/ G6 DUS——the Axis of Evil！+ w, o' s( y: B3 J, k
2011-4-4 01:19
7 }9 o( l. R0 g  [9 j1 Q  G美国是世界的邪恶轴心！4 M" b7 o! O" B" u- m
sunsong7: 沁园春.血               ---作者：萨达姆   日 本 风 光, 千 里 地 震, 万 里 海 啸。 望 仙 台 内 外, 废 墟 莽 莽； 东 京 上 下， 顿 时 逃 逃。 核 站 爆 炸， 世 界 惊 涛， 地 震 海 啸 试 比 高 ... (3-22 21:25): P1 o( I! }* e" H4 S/ J
2011-3-22 19:06: K; ^7 \1 c/ l4 U2 }
teratoma is derived from endogenous iPS！
3 P2 g; S7 I6 w; ^% S" k2011-3-15 21:44
0 q& w& [6 W0 g# Z1 Uips is a luxury gambol on  
3 X7 A# Z9 o8 A& u" w) E2 s; G2011-3-3 14:506 d1 `$ F* h( ?" C
cancer is intermediate of species evolution
5 G6 y/ A% D. h7 B2011-2-12 12:29( H% q1 c- v) b+ b# D
stem cell now is on the eve of coming medical revolution8 M5 O& V1 a5 m  k0 |* _& c
2011-2-12 11:20) S1 i! C/ z. h7 v  U, ]
Inflamation is the reprogramming process of somatic cell in vivo！
# z# L; u- H; @* ~2011-1-31 14:49
# Z9 _' T' M4 X& ^. h/ A% R# ?so-called medicine is niche regulator！
5 ~) S; o6 @! c6 V- |4 d2 M2 W  G2011-1-23 21:45
7 I; I: W! e. ^endogenous iPS is the cancer initiating cell！" M) j( {* I7 G0 f; Q' r
2011-1-17 16:47; Q2 e( ]6 z' [( f1 r. \
cancer is unicellular organisms！! }; C  G8 L/ r" {% q$ l* R9 }
2011-1-9 22:047 K$ q+ ]4 y( x. Y
Pandorabox Has Been Opened
8 F# {+ h5 n" s5 b# L" s0 Z2011-1-7 23:24; @% m$ Y4 p* t2 q
iPS is the Emperor's New Suit ! + b2 O) y% X, Y% k. K# _9 I
2011-1-5 23:50
; K! m8 X. K7 M" Z! Lcell-free is the final solution of stem cell therapy
1 W8 C! j& b1 L& M8 N8 {2011-1-5 21:46
. B1 U+ D. d) N, I/ s9 r& Y2 ?niche is telling the story of stem cell.../ H4 \) J# N& p0 s/ @
2010-12-29 17:32
4 X; y; `+ q+ w1 [  Acancer results from reprogramming of somatic cells, x" _. b' d* F! s% J
2010-12-25 18:56
% m9 P) m  f0 y1 s( c& g# lcancer——good cells in bad niche！
- @6 g7 B" Z, W& P) M) N2010-12-25 16:02
2 t9 B. P, Z2 ccancer无罪——制造产生罪犯的土壤才是真正的犯罪！
1 m& _4 X  [: x! b( Qderon: 灰常同意，有相关文献么？ (12-19 09:41)9 @/ V* J# J+ P' J- x
sunsong7: 呵呵，请来参加讨论——癌细胞的发生可能是一种“返祖”现象？ http://www.stemcell8.cn/thread-32073-1-1.html (12-19 11:33), u  B/ x1 q- d2 }( y
sunsong7: 问题讨论 http://www.stemcell8.cn/forum-re ... 709-pid-246202.html (12-19 13:29)
: V9 {' x  h9 P) F' }( f7 ^2010-12-18 15:54
6 e, j2 X& _$ ^+ I: K1 e7 _子曰：上善若水 大成若缺——干细胞治疗的终极解决方案将是不移植外源干细胞！8 Q' |0 I; y1 P) E2 L; X8 v2 Y
2010-12-15 15:078 m+ u. R+ X2 f0 |2 M
老狼的记忆——大洪水
( X  g0 g9 i5 ^4 x- F2010-12-13 23:25$ y8 I* l) q$ ?) o% G0 P
can cancer randomly differentiate into norml cell in vivo  1 K9 Q8 H) x- t! q
2010-12-13 22:33
* n# \( d* M1 Q8 e) T# ~! i) Domnis cellula e cellula
/ Y' K) _) K8 }! a7 l! Y: X2010-12-12 09:28+ k' `' x( x& b# Q
Stem Cell ——The Origin of Disease% u" B  _' ~8 W, _
2010-12-12 09:27$ Q2 N% d2 q: l4 x$ M  X

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