老狼的个人空间记录

sunsong7

"genetic mutation" should be exactly as "gene self-editing"
9 e2 H5 O5 a8 q$ a4 K! m: u2017-12-1 13:17/ }! P7 s# [0 W: K: ]. p5 p4 |
Bioreactor in vivo would be the terminator of illness.
  @, H4 {$ h! ~+ ?( H3 J2017-11-20 23:097 s  J# e( h$ f: K/ n, T  T
renew tech：剔除衰老（病变）细胞占位可以恢复青春。2 T# v7 C" Q9 G3 u, j& _
2017-10-23 12:502 w3 Z& P' k* t# k- a
魔不疯，鬼不魅； 道非盗，仙非妖；神无形，兽无极。
' |5 S. ]' C/ a2 |2017-9-30 10:58) g: c+ l4 |! G9 D/ b6 x5 V
Life 3.0——from decoding and coding to reading and writing
* J+ i/ |, J/ D- d: {2017-9-21 22:32, \. K( h$ U  r9 p- |+ V# i- s' _: j
理论创新：亮明立场——先颠覆，再完善, J* N" t! b8 R1 l- T0 C0 _$ a
2017-2-7 00:07
' p/ I" K& L4 V& `干细胞第二定律：与细胞外基质共同构成多潜能；
: C. ?1 |" L% e8 B7 S2017-1-3 11:146 V  C- K+ ?3 J) k: L% r' {
干细胞第一定律：全生命周期保持增殖分化能力；
% F7 \- R/ y& k3 }3 `* ]2017-1-3 11:13  n0 _! R! _8 k4 e& b
NgAgo——Never give A guideline operated！
9 f) s2 L! X" b3 A8 q+ Z4 Q2016-12-1 10:093 Q- B& R1 Z! z. q6 R  J- {
表观遗传—— 一切皆可改变  一切皆有可能3 x; I( ]/ [& Z$ }; r/ h
2016-8-17 23:37
3 T  t% u( ~  T8 R8 F4 x子曰：吸血鬼疗法——养儿防病 养孙防老
; T' }+ G* Y$ q8 }3 Q$ Q2016-5-23 12:05
/ |* U3 B/ Y$ l6 M3 N! pNgAgo——Debug tool kit for mammal cells( o( J0 ~: T5 x( E# W6 d
2016-5-9 13:09
8 |6 X: j; v% i# u+ y公理之外 皆需证明； 科学命题 皆可证伪。9 ^( W. Y, e$ [6 Q- V% O) K" d
2016-1-2 00:20
" P0 d: [- d, Y3 r  g" N低氧——破坏线粒体功能、诱发炎症、导致基因突变
7 \7 b( }/ V5 O+ N% @2015-12-16 20:19
) e" Z# ?( `2 ~! W- M6 \7 t癌症——炎症部位组织再生过程中细胞去分化失控形成的幼稚化新生物。
1 l1 K. j0 }1 e1 M  ^$ O$ ghcoohboy: 一个有趣的假设~但是没有炎症就一定没有癌症吗？ (12-18 16:16)
8 P2 G6 t0 h4 \, {( Isunsong7: 炎症与癌症同在，Hanahan D, Weinberg R A. Hallmarks of cancer: the next generation[J]. cell, 2011, 144(5): 646-674. (12-19 19:45)
) j2 b1 @0 x# f& n8 V" Q! f5 t; phcoohboy: 3ks~ (12-24 16:45)
: G4 ~) A4 A" _3 V+ s2015-11-18 15:544 K- w: a# y; }- `, N0 v
抽象世界与客观世界的真理判别标准是不同的： 在虚拟数学世界里，逻辑是一切命题的唯一审判标准； 在客观物质世界里，证伪是一切定律的最终审判依据。
" k' D9 j: I, \1 X$ g6 Q% ?2015-5-20 14:139 N0 H! {  o) N7 w, W% Y7 q
传统生物学将死：进化论=自然神论   基因轮=宿命论   细胞论=活力论翻版。    现代生物学曙光乍现：系统生物学=数学 结构生物学=物理学 合成生物学=工程学5 h( R2 E9 S+ j" X, g1 E  x% Q; }0 k5 J9 C
helong: 系统生物学是把细胞、基因、进化、物理学、信息学（数学）、工程学等都打包起来的所谓新学科，目前只做到了简单组合，还没有达到系统集成阶段。合成学更多偏向于化学。 (4-21 19:28)
" P6 g3 X# n, t0 A. p7 f' J5 usunsong7: 方向对头，努力总会有结果的 (4-21 20:05)
; j0 e2 H- ]2 v9 X2015-4-21 16:46
" i5 y8 a  U$ }' d' B2 Csearch and research is just disassembling the creature.
" J8 s6 c1 H! `6 i# G4 Y' X/ L2015-4-7 17:01
8 J8 e- U% t/ v  I9 h0 k( ?selection is  the act of intelligence  f7 @0 }( f, G
2015-4-7 13:490 l8 ?8 p- h4 [0 H$ d0 O
Genome fusion create neoplasm7 s, }' H9 Q4 m8 B# l
2015-1-20 13:10
" H/ M7 w! f" S1 tSTAP——Stupid Trick  Against Professional 
& U8 e" A4 C0 C8 m# x, E2015-1-1 19:29
: c: d2 j( p3 ^4 R* {, Tinformation=structure=negentropy3 Z/ P4 Z/ w8 t" v$ f2 g
2014-7-22 17:36
% e2 y! o9 p0 n' M, BNatural mutation does not result in new functional genes 
+ `: |( D7 [2 q7 G! {2014-7-3 14:06; |/ c/ Z% u& B0 A- F- m. r+ @
life is wisdom creation instead of natural evolution
6 a% K/ v& m: U, ]* z2014-3-27 09:33
/ j- Q6 R- W$ x: Llet us explore the source code of life !
; u) I5 r0 Z1 b3 \7 ~+ \2014-3-11 13:11: w" k( X8 S7 C3 O7 P# N$ Y
bio-manufacturing——processing，machining，casting，printing，3D prototyping，duplicating，cloning，life replicating.7 O  p$ J3 b. L; Q: A$ W: Z
2013-10-7 23:06* ]: g7 _5 K3 m0 ^  P: o  }! R& w
induced abortion would give the key for curing cancer 
+ ?( s& W, U/ L' f5 W! [5 ?) U2013-10-2 23:331 a" i. e1 q1 ], W2 L' k
“key breakthrough” in molecular biology are entertainments
- H# y3 ?9 j+ L2 Y( s) g1 ?- B) p* K1 T2013-6-16 11:50) @1 s0 G* ]& t. }$ V
Rules Of Living：trial-and-error exploring，survival takes the legitimacy
6 L% }/ S1 S2 k: x5 B. F2013-6-16 11:27- J- R7 m/ O% g* c! L( N
Life is a set of debuging programs
9 Y, v, E& O: ?; }+ R1 B2 k2013-6-15 18:40
% q# |. c7 X. X) {# X) }/ ~: Lcurrent biology is closed，destined and agnostic，it is  the only contribution is to kill cells
! i6 ?9 H3 p( u. m4 p3 q2013-5-2 08:545 G; M3 T* P- i* `5 O
information，energy and construction are the new base stone of biology，instead of evolution，gene and  cell  tales
" c1 [, p/ Y+ t2013-5-2 00:51! h  o1 @* Y0 Z* y
virus is the messager of  the universal life network
1 w3 [& X( d+ u8 i. L1 e2013-4-18 14:33; y5 z# _9 t  a' x* k
Genetic information doesn't improve cancer risk prediction2 ?3 M# R( u0 G7 ~1 D
2013-4-1 09:20
. r+ `/ F( V1 ~' h0 a' VThere is no early diagnosis of cancer，but early prevention of it
/ u$ j5 W9 s1 e, m. p- J# ]! [2013-3-27 09:17
7 G6 g' ^7 q! Q" h( ihypoxia maintains stemness or carcinogenicity' h) u) T6 X$ ?$ x1 r# L3 t& X0 X, @0 p
2013-1-2 05:21
9 x3 X9 i9 H" z. g8 [& a9 Y+ w7 `0 J% b) vcancer is the living fossil records on origin and evolution of human being& T0 M7 k8 P/ f0 y: E
2012-12-9 23:312 {% D9 l/ N3 P  A+ C
information island results cancer+ ~8 a: ?* r. ^& X
2012-12-9 05:23+ n) Z" y5 J! R: H' p. B) y8 m9 T
life is digital game# y) M4 B5 U2 @0 b2 g7 Y
2012-11-10 00:175 Q, _- d, L  k9 Z
cancer ——severe abstinence reaction of cells to niche addiction: |# ]! n4 A- F6 }/ q. u7 a
2012-9-28 12:11. j( v' c' i! k- U$ v
未来生物学终将回归物理(熵)及数学(分形)的美感
  C3 X. T0 F+ P! ^biomater: 熵理论适用于任务物质。。。。也适合于生命 (9-26 09:28)
6 H4 r9 `! E  I. l1 k% ]# a8 ^2012-9-25 21:22
" Y8 W/ }9 H8 x" }- wmembrane holds the key to life
+ i1 A; F' Z" |" l7 q, j2012-8-19 20:24* j$ ~( G) {+ K8 ~
Cancer is the default state of cells( M3 m8 D) y2 {& [" n
2012-6-26 22:17
  J. M; v/ W7 Y3 L; u) y* L' `mainstream cancer theories could be overthrown！9 t7 O4 w! l3 `, y
2012-6-25 15:43
% v8 ?8 P! ?2 H7 V. k1 f: r7 tcarcinogenesis has nothing to do with the gene mutations but is  the result of niche reprogramming.../ t) x" O2 N2 X9 o: ^
2012-6-7 09:36
" J: a* \) H0 ~. Oevery living organism connected with the water， one cell one world
4 P8 ?) w/ a: t! b# x/ v& J2012-4-19 22:06
! N( L% R# L$ q, c0 D/ h+ N3 G; qchemical structure of cancer cell determines it's biological function...
* Y+ ?1 Z! q7 L' P" E# Q2012-4-7 17:56
' {4 a, Z! f, D! V3 A( t4 cMann tracht und Gott lacht( r: V* v7 k. K
2012-3-24 21:34
9 c8 c6 R0 X; x) J- T; [Darwinism or genetic determinism is a fairy tale！
0 Z2 I- D- u$ q! A2012-3-13 15:181 t' A$ K* U$ Z$ g0 U) s0 i1 {- S, b
niche isolation is essential for cancer speciation
) h. z2 O& r/ Q/ ~+ r2012-3-12 12:07
3 T+ @; o( \2 e, t7 gHybridization Creates New Species，Mutation results species extinction
" h- a- y3 e$ \, \2012-3-11 18:21
2 b. b0 q% n* X/ y" W+ l. w6 uROCK may join the niche reprogramming...
" T5 D: b" U( x, P+ Yyuhaoze: 这是篇文献吗？ (3-9 10:41)8 T" z/ P' [( @& a
sunsong7: http://www.stemcell8.cn/home-space-uid-6268-do-blog-id-1211.html 突破：病人体细胞及肿瘤细胞长期体外培养（附原文） http://www.stemcell8.cn/thread-51419-1-1.html (3-9 10:46)4 \. \$ k: {6 S; X. o; Q" r
yuhaoze: 啊， 我看过这篇，还顶了呢，谢谢哈 (3-9 14:37). H4 e0 W- @' X$ i0 Y
2012-1-19 10:52  @  K* U. U# U2 Z
oncogenes are pseudoscience
. C. h  f6 ?! R' G9 C) `2011-12-29 13:55
& c4 j9 P/ b, r3 p7 ~; o0 Ygene mutation leads to variation or extinction, not new species8 q1 J9 T% Y1 a$ A. M
2011-12-29 13:28
* ?: [; e. T6 U5 o" @oncogenesis is non-Darwinian event
& j  ]) a5 H4 A8 C8 \5 j2011-12-28 22:56
( m% J" b# I: [8 P0 Adisorganization activate neurogenesis activate oncogenesis   7 J; c) q) C3 ~* X8 f' k
2011-12-22 23:381 d1 `' d5 F8 f$ P8 R
MSC is cell feeder，tissue scaffold，immune firewall and biological glue, I1 j- ]! C! a; t
2011-12-19 19:46
: _. K! B) l: K" f: D4 R7 Wcancer is Noah's Ark（species carrier and life explorer）
) r$ g# B# c* X7 u2011-12-10 09:46
0 ?" K% f9 S, G7 S: @cell fusion create new species, gene mutation induce variation$ s- b5 }! ?( H; P' Q5 M
2011-12-10 09:36' Y, a2 f6 y) d2 I% u3 h/ b1 x, W" h
GVT will be cancer terminator， Cytokine storm will be cancer preventor
$ h+ u7 k: \2 H/ L6 \" U2 y  U8 x1 p2011-12-8 12:568 p. d$ p3 p8 ]
cell fusion results regeneration，reprogramming，neogenesis，atavism； cell division results differentiation，apoptosis，senescense，development;0 k& P# d% t& w9 Z- G) j  `6 F
2011-11-27 14:543 k. D3 S6 C. |
Cancer is between protozoa and mesozoa， not metazoa...9 U: R+ i& }: r
2011-11-27 00:25
( Z# Z* E) A& h& @  h: u/ |  S9 Scancer is neurological disease！ haha，I got it！3 M& V$ k3 Q8 a8 y8 A7 T
2011-11-22 22:06! k  z1 d" ]* Z- T# q
you are cancer，fetus is tumor. 佛曰：汝既是癌 癌胚如来; f' d: p- T2 z/ z; j
2011-11-12 11:27* \/ f4 {& y1 R, ?+ ]2 T; J$ |
cancer is the ecological invasion of hacker...5 {# Q% J# f4 _0 h) U
2011-10-5 10:31
  O; B; O5 h% ]3 A3 rmicroRNA is  negentropy？
: q2 u) a" n, b7 J8 ?6 T; V6 B0 ~+ C2011-9-24 00:48
, H1 s8 E- f4 P) i% Acancer is the social problem; }) s% j- j6 g+ |
2011-9-9 23:331 Y" Y# B; Q) ~/ g- N2 g5 D
Science is the games of nobleman or madman% H( n" T) _4 l  z5 H& q
2011-9-2 15:035 p; z) s) E" N5 U) s3 k
cancer resulted from disturbance of biological liquid crystalline state of ECM
1 H- ]# t6 O; Q; [% u( s: \* g2011-9-1 20:13) e! I& [( e6 S( [5 d5 G
niche n-dimensions——space, time, momentum and entropy; energy, material and information flows; physical, chemical and biological factors；topological, thermal, and fractal influences...
8 N. e9 {/ S& o; W5 H2011-8-13 00:37
* f  \( t. u3 p" g; ~Second recession is coming？
2 @! V2 r- u1 z2011-8-9 23:58
4 O4 J6 V9 L8 e  bcancer may be from sexual reproduction of somatic cells.
+ N9 T9 T3 W5 E' f! F0 a/ ~2011-8-7 00:16
+ I2 @/ f1 l. f" k4 E! Pwho determine gene？ genetic determinism is fatalism！  g" W3 s; O9 u, s* x0 Z1 A
2011-7-30 11:26
# W# _4 l3 k5 K) gniche reprogrammabllity is the key of solving cancer problems...
0 G  E) h+ l" B; k' Usongtianlong: i can't agree more!!!O(∩_∩)O~ (8-14 20:42)
* z& L, j4 ^2 B) F% r6 Dsunsong7: hehe. thanks for interested in this topic, welcome future discussing (8-14 20:54)* f+ V/ W$ p. J( W) E+ a  ?
2011-7-24 01:24% N2 k: X0 y- b4 h0 t' O8 k
cancer results from acquired genetics alterations.
# k3 q6 c* g- H2 @5 R$ Z  k2011-7-20 21:37
; P! h, J, `" f, SCSCs are the low differentiated cancer cells in G0
9 a) _; @* o( [7 X/ u- O( w2011-6-29 16:30
: j' v4 n: C: S( `. Y( o5 \5 J2 XiPS future——in vivo direct reprogramming ...
" q, m- B# d3 S. z2011-5-31 15:20! T: E6 N8 U9 K1 V. R5 M/ ~% f& h) _& h% v
niche reprogramming——cell fate will be manipulated by cytoplasm - microenvironment interaction http://www.stemcell8.cn/thread-40755-1-1.html
0 `$ Q! u# X. O/ D4 ^- z- M4 n2011-5-31 01:283 D* \# G7 e" f+ b$ o# J
all the somatic cells of Mammals are totipotent ！0 F2 S2 E2 f0 h% n8 A& o& S
2011-5-22 22:22# K0 s0 U6 _) m8 b' ?7 v, x& V
miRNA——The manipulator of  cell fate！8 l0 |! X0 W6 Z$ b
2011-5-20 20:212 p  I9 m. f9 T* L9 k2 |
《Cell Stem Cell》means “cell is stem cell”   活细胞就是干细胞？
& D2 [8 D+ \2 M; ~2011-5-17 12:38
' p: M- p# W8 ~" ?0 ccancer —— good nuclear in bad cytoplasm！RNAs are cytoplasmic determinants determine  cytoplasm determine cell fate！ division is differentiation is cancerous is life ！- s/ v0 S; A" U
2011-5-11 12:314 ~9 F+ `4 e# G+ l! @
cancer results from cell dedifferentiation...! _, Y* W& ~: D) X. A/ J
2011-4-28 18:071 U; j0 k1 x, }/ E
differentiation——asymmetric cell division ！
& w: ~; a1 h1 p) ]6 F" _: d2011-4-28 18:04
$ c0 k4 Y& A3 e7 }8 u* }- Pcancer origins from the regenerative cells！/ Y/ N0 V5 o$ @+ V: m4 A1 x
2011-4-28 17:52
4 P5 v, u% n. {0 n. M4 ^( G( BProliferation is differentiation potentiality！- A7 j2 Z5 w) d) B
2011-4-28 17:49# O' r& O1 x! d: C0 P
iPS——the key of Pandora box！/ q. q# f0 s! K$ [  P
2011-4-27 22:36
0 N% ]+ n6 h' C7 `3 M; JAristotle— "The whole is greater than the sum of its parts."
! S* _# E, B. i7 J5 C2011-4-27 00:203 q0 C% F' J3 D" U
cancer——atavistic cells, N, f9 v" F4 F5 p6 ^
2011-4-20 00:20
# ~& E/ e* _2 o- N2 Ucancer——cellular atavism！. P: }8 V9 Z4 V0 m# j5 d0 N$ e
2011-4-20 00:18
9 b- m7 }! E! T2 l! t% r0 c( Y' Qcancer——evolutionary ancestors of mammals.& z- e6 x0 R* s) j1 K: w  q  u9 R0 ]3 A2 O
2011-4-20 00:09* g1 e  h/ n' A3 V! V. S  B/ B; F
肿瘤是细胞自组织缺陷的产物 2 p# d4 U; U5 H! e: K* X2 N
2011-4-17 01:41/ J2 n) C( \; G; V
cancer——Metazoa 1.0
$ g1 k" j+ C& v% A; u- p& Z' H2011-4-17 01:00* b% g& O" J" \
US——the Axis of Evil！; i3 ]) u/ z* ~2 ]7 p  R4 ~* E3 @. }
2011-4-4 01:19
9 n1 p7 y+ ^9 a  e3 q美国是世界的邪恶轴心！# V7 [) E' U% \4 ?
sunsong7: 沁园春.血               ---作者：萨达姆   日 本 风 光, 千 里 地 震, 万 里 海 啸。 望 仙 台 内 外, 废 墟 莽 莽； 东 京 上 下， 顿 时 逃 逃。 核 站 爆 炸， 世 界 惊 涛， 地 震 海 啸 试 比 高 ... (3-22 21:25)
0 P! Z) i4 y. y3 K0 k' j2011-3-22 19:06& p4 V4 A$ `# h2 {( Z4 h) r8 R
teratoma is derived from endogenous iPS！
, X  b. c2 ~  B2011-3-15 21:44
! V' ?6 Y; H4 n. W! d1 Y7 z" t5 t& Oips is a luxury gambol on  ; a7 S8 q: A  a, j
2011-3-3 14:50
- T/ K5 c: i& X2 L% mcancer is intermediate of species evolution
3 C/ K7 u6 K  }& i6 p* k: g2011-2-12 12:29
' r7 M, Z4 k# x; k6 o  Gstem cell now is on the eve of coming medical revolution
6 {( O' l; s( H2 Y) p5 [2011-2-12 11:200 C" r, e: X1 f; D9 L6 K
Inflamation is the reprogramming process of somatic cell in vivo！" ^; ^6 b! H/ Q  O
2011-1-31 14:49
% |1 h0 |  X0 ~so-called medicine is niche regulator！
2 b1 ~6 ], ~: o, _) {) v2011-1-23 21:45
; @4 k7 }* D9 q: F: Q; [2 F1 e( dendogenous iPS is the cancer initiating cell！: A6 X* g7 v) ~6 \" d  M( n" s
2011-1-17 16:47& n$ [5 _& m5 |
cancer is unicellular organisms！; A$ q7 `0 V9 V6 \8 ?
2011-1-9 22:04
7 h8 n( y' N- C" l4 ~! UPandorabox Has Been Opened
- {5 x7 B. Z, [6 f1 m2011-1-7 23:24: Y! E7 r+ C& S6 ]6 ?
iPS is the Emperor's New Suit ! 
, r2 _& o4 i4 q7 C/ |+ H2011-1-5 23:50
3 P* d" G, _0 `0 d/ n: kcell-free is the final solution of stem cell therapy
) G; W  A  J+ y& ~1 y2011-1-5 21:46
$ G0 }/ r0 l9 F( kniche is telling the story of stem cell...0 b  d8 U3 [' p$ A
2010-12-29 17:32
9 j# e, D, t* y+ Ucancer results from reprogramming of somatic cells
2 w; i% u; [0 Q  j/ ~. t" }2010-12-25 18:566 S' H* s& U; h3 R# k9 F8 s
cancer——good cells in bad niche！' |+ @& |8 }' \: Z
2010-12-25 16:02
' j/ t1 t  L4 I% v+ Dcancer无罪——制造产生罪犯的土壤才是真正的犯罪！
& U* P: k" |7 T" r/ e* fderon: 灰常同意，有相关文献么？ (12-19 09:41)
- _$ p% \8 ^/ E- q$ W% m' @* `2 D1 Ksunsong7: 呵呵，请来参加讨论——癌细胞的发生可能是一种“返祖”现象？ http://www.stemcell8.cn/thread-32073-1-1.html (12-19 11:33)% |3 m8 N- S( y7 @
sunsong7: 问题讨论 http://www.stemcell8.cn/forum-re ... 709-pid-246202.html (12-19 13:29)6 }3 r+ Y- a: Z# t
2010-12-18 15:54/ u7 X3 p3 i& y7 G7 F* E% d
子曰：上善若水 大成若缺——干细胞治疗的终极解决方案将是不移植外源干细胞！
1 |; N. C3 V  C  i2010-12-15 15:07% {2 v2 v8 z  ?+ b
老狼的记忆——大洪水3 J" ~* r: K, V9 X. n& D
2010-12-13 23:25! B/ g6 Y' v3 f! c% B- {$ d: B
can cancer randomly differentiate into norml cell in vivo  3 r3 h$ ^' A+ v6 C# }; p+ |* s
2010-12-13 22:33; U2 J' B) D" b0 }+ M3 ?
omnis cellula e cellula
" N" {/ I/ Q2 q! V9 l2 c* y" B2010-12-12 09:28
, v0 d/ [$ L, VStem Cell ——The Origin of Disease
* A$ d  w  k! ]4 o1 |# u' k  I2010-12-12 09:27
+ ?0 z9 e0 u4 v

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