老狼的个人空间记录

sunsong7

"genetic mutation" should be exactly as "gene self-editing"
) k" f# y, Y) [" J$ _0 I2017-12-1 13:17
0 j% {6 O5 \" C1 J" OBioreactor in vivo would be the terminator of illness.9 p% o) b$ W* x* X  O
2017-11-20 23:09  K% O: j6 k5 O" m" d+ b% V) F
renew tech：剔除衰老（病变）细胞占位可以恢复青春。
9 }# s+ J9 ^6 ~( B% q( c2017-10-23 12:50
! |8 Z, x7 q' K7 z: {$ S! `1 e魔不疯，鬼不魅； 道非盗，仙非妖；神无形，兽无极。
4 p9 }5 F4 ]$ t& P2 a5 q+ D% ]) z2017-9-30 10:58
$ Z7 d% i0 K4 N: `+ H) hLife 3.0——from decoding and coding to reading and writing4 D0 x7 M& A, o  M9 @2 k5 Y" L% V
2017-9-21 22:32
" o* _" @5 d, j% B' n3 I理论创新：亮明立场——先颠覆，再完善: Y& j4 N6 j6 {
2017-2-7 00:076 o4 r% E0 w0 b3 y4 P& c
干细胞第二定律：与细胞外基质共同构成多潜能；0 m2 z1 A' G  V3 S" s& l
2017-1-3 11:14  o# X/ f/ h1 C9 a
干细胞第一定律：全生命周期保持增殖分化能力；
+ [0 Y" ]) X2 x, c2017-1-3 11:13* G/ P# |. g; w  Q9 T9 T2 }
NgAgo——Never give A guideline operated！
- T/ T# ^: }7 T. R2016-12-1 10:092 Z# ?; A! ~8 r, x7 E) s
表观遗传—— 一切皆可改变  一切皆有可能1 ~* t8 l% n" r/ Q2 |: T, `
2016-8-17 23:37
+ p9 P3 E( Q8 @/ \子曰：吸血鬼疗法——养儿防病 养孙防老: F" X( V8 I: o) k  U
2016-5-23 12:056 Y  d: Y7 [: K/ J. a. H% T% X/ I7 {
NgAgo——Debug tool kit for mammal cells
; T: E3 p" E% s' I& }$ A8 e$ y2016-5-9 13:09
; u2 Z2 c& M: o. F# w7 F" `. G" v公理之外 皆需证明； 科学命题 皆可证伪。0 O6 A! V( ~! Z6 u& d
2016-1-2 00:20; Q4 d' c: k4 x, x0 i. X5 h, a* x
低氧——破坏线粒体功能、诱发炎症、导致基因突变
8 o  T' v7 b. v1 n2015-12-16 20:19
+ [% P/ C% e) v) W1 A: m/ W癌症——炎症部位组织再生过程中细胞去分化失控形成的幼稚化新生物。
4 f9 H. s/ s- s3 r2 h' Mhcoohboy: 一个有趣的假设~但是没有炎症就一定没有癌症吗？ (12-18 16:16)0 d! y  o# w1 s( l$ {$ v0 m  ]- s
sunsong7: 炎症与癌症同在，Hanahan D, Weinberg R A. Hallmarks of cancer: the next generation[J]. cell, 2011, 144(5): 646-674. (12-19 19:45)% E, h* }9 N! w/ ]! E* g
hcoohboy: 3ks~ (12-24 16:45)1 O: N! l0 x7 B8 o" w
2015-11-18 15:549 o/ f& w& r: \  I/ `
抽象世界与客观世界的真理判别标准是不同的： 在虚拟数学世界里，逻辑是一切命题的唯一审判标准； 在客观物质世界里，证伪是一切定律的最终审判依据。+ A( v- S' u) v' u- a* A8 @  {6 M
2015-5-20 14:13
7 @5 e4 |$ G4 K 传统生物学将死：进化论=自然神论   基因轮=宿命论   细胞论=活力论翻版。    现代生物学曙光乍现：系统生物学=数学 结构生物学=物理学 合成生物学=工程学# V1 {0 V2 X) J) A0 w
helong: 系统生物学是把细胞、基因、进化、物理学、信息学（数学）、工程学等都打包起来的所谓新学科，目前只做到了简单组合，还没有达到系统集成阶段。合成学更多偏向于化学。 (4-21 19:28)2 I& M$ p0 D7 c; R9 ]; z
sunsong7: 方向对头，努力总会有结果的 (4-21 20:05)
4 I7 G8 T+ z) p) V- _& m1 D+ t2 V4 X2015-4-21 16:46" U3 W: X; U6 |' v/ w& W  `
search and research is just disassembling the creature.
" l" m) w2 t7 d7 f7 U- |2015-4-7 17:01
) u9 P7 V/ D& V: ~selection is  the act of intelligence
3 a& D# }8 _2 F2015-4-7 13:497 D* F% T- D. s' n. `
Genome fusion create neoplasm& [5 I. L! l+ t9 r0 {, Q
2015-1-20 13:10: U0 g( y- m( n+ ~" v/ |" e
STAP——Stupid Trick  Against Professional 
8 w8 {. x' G* @3 A  {& t2015-1-1 19:29
7 s$ T" c: `/ J, k4 t! q3 M( G. Rinformation=structure=negentropy
4 x" z3 s+ r: d+ z6 u$ |0 |* Z2014-7-22 17:369 V7 y! e6 ?3 ~& v$ p" Q
Natural mutation does not result in new functional genes , ^  C0 x, D$ c- R6 ?
2014-7-3 14:06
1 c0 k$ K* C8 Jlife is wisdom creation instead of natural evolution$ P8 L. E" q# F% h3 T0 ?
2014-3-27 09:33# Z5 W' M+ O% z9 m- t* x; n
let us explore the source code of life !7 Y: B% T. Q' j
2014-3-11 13:11
% @9 z4 `, I8 p* o. B1 q+ {bio-manufacturing——processing，machining，casting，printing，3D prototyping，duplicating，cloning，life replicating.) P! ~: Y& i4 {/ E* u3 l5 ~; l
2013-10-7 23:06
. a# K$ E) J9 W! F3 Binduced abortion would give the key for curing cancer 
; j- N6 b2 i# O: d2013-10-2 23:33% z; `0 _* `2 J1 F! ?
“key breakthrough” in molecular biology are entertainments" q# G2 J9 M" i- ?* y* V
2013-6-16 11:50
- N2 q4 ~2 `! K! Z, |Rules Of Living：trial-and-error exploring，survival takes the legitimacy2 Y6 k* z5 p8 ~3 @% |* V
2013-6-16 11:27
+ g" v# q/ W0 p1 }  Z# xLife is a set of debuging programs9 o  h6 U& }2 f/ _: d
2013-6-15 18:409 y/ x. |7 C- T6 o0 K# J! m& Q* m' {
current biology is closed，destined and agnostic，it is  the only contribution is to kill cells# [9 E, g! O, O- c6 l
2013-5-2 08:54
/ K: f* N  \+ T$ G0 U; Y- ~information，energy and construction are the new base stone of biology，instead of evolution，gene and  cell  tales, u4 ~6 k! ?8 S1 h4 }; n  }
2013-5-2 00:517 {" O' k& z0 }$ F* T! G3 A
virus is the messager of  the universal life network
$ X0 g5 @+ F& n/ d3 D5 E( E8 t2013-4-18 14:33! F3 G6 B: Z- V  a( F/ S4 t5 B
Genetic information doesn't improve cancer risk prediction
, y" p6 W1 M" @2013-4-1 09:20
7 ?9 k. i' V8 ^5 a2 v6 [There is no early diagnosis of cancer，but early prevention of it
" M+ X! Y: e- A2013-3-27 09:17
% t" y" X( ?: Uhypoxia maintains stemness or carcinogenicity( K+ S; Q! X, O
2013-1-2 05:21
7 B6 [3 X9 @  B2 I9 Ocancer is the living fossil records on origin and evolution of human being
  G- n2 N) M, l( Z+ O9 {2012-12-9 23:31: g+ b7 h- H. Q
information island results cancer
$ U- g5 s4 I: Z0 p5 J2012-12-9 05:23
; D5 P% L: a6 a' Jlife is digital game& t& }' M9 p& W. ]) w: _$ P: n
2012-11-10 00:17$ D5 K# a) w- M5 A: `! u, F
cancer ——severe abstinence reaction of cells to niche addiction9 `: s9 q  ~4 l, X% Y1 ]
2012-9-28 12:11
3 G4 b2 Z, ~3 ^5 ~' M8 }未来生物学终将回归物理(熵)及数学(分形)的美感0 h/ ~1 O# v% q3 X; P, k) q7 E
biomater: 熵理论适用于任务物质。。。。也适合于生命 (9-26 09:28)6 C; B. L& K# }$ h
2012-9-25 21:225 G- D5 V" q, q, n: R
membrane holds the key to life
" C* s( V! Y  o8 g% X- a2012-8-19 20:24' B3 a, c& |. c# x, k" Z% Z
Cancer is the default state of cells  e( W  n4 q$ K7 j
2012-6-26 22:17% }+ j( n. w# t1 H
mainstream cancer theories could be overthrown！, Q# v. X5 o" J0 }
2012-6-25 15:43
- W8 w6 p  s8 _+ T5 ~" Zcarcinogenesis has nothing to do with the gene mutations but is  the result of niche reprogramming...
' W' B4 n$ M$ e& _$ H8 S2012-6-7 09:36
5 q- K5 |( D% o9 Yevery living organism connected with the water， one cell one world* i2 o* E. A' q, a0 Y3 h
2012-4-19 22:06
5 w1 U* S4 n4 d( Gchemical structure of cancer cell determines it's biological function...
' S1 Q- `# }* e2012-4-7 17:562 X5 ^% @5 l$ Y9 l! j$ H: ^: W
Mann tracht und Gott lacht
5 Q- ^( I2 U* E9 l4 e4 ^6 u9 j; d2012-3-24 21:34
. D0 \# j0 g5 i  f* e7 y% fDarwinism or genetic determinism is a fairy tale！
% @/ A8 s7 N, H9 l0 D! `2012-3-13 15:18: ?2 d- m# O1 j/ q
niche isolation is essential for cancer speciation
' [8 B/ z; s, D8 U2012-3-12 12:07; g( _% u) l, m' b! L% D" x4 L1 ]1 [* o
Hybridization Creates New Species，Mutation results species extinction! P0 |  z; X0 L* m6 T, I
2012-3-11 18:21) G4 l& m0 m/ a
ROCK may join the niche reprogramming...1 V& {, Q7 U. B/ s
yuhaoze: 这是篇文献吗？ (3-9 10:41)) m; U- K7 z# B& c
sunsong7: http://www.stemcell8.cn/home-space-uid-6268-do-blog-id-1211.html 突破：病人体细胞及肿瘤细胞长期体外培养（附原文） http://www.stemcell8.cn/thread-51419-1-1.html (3-9 10:46)- S, U: K' P. F; P/ m0 }5 Z
yuhaoze: 啊， 我看过这篇，还顶了呢，谢谢哈 (3-9 14:37)+ `) i7 O6 m4 K/ H# u
2012-1-19 10:52) ]# t; l# K6 H4 v% Q! U/ v" o
oncogenes are pseudoscience
5 z8 M9 {  a$ x2011-12-29 13:55& P! \7 @2 n% Q& a! T/ L8 \4 Z
gene mutation leads to variation or extinction, not new species
* g) T! U3 W" w9 }' @; |9 r% Y/ K2011-12-29 13:281 M9 R. d; t9 Q3 l; s6 `
oncogenesis is non-Darwinian event
/ g1 A" h; y. w  {2011-12-28 22:56  A6 F# \/ U8 p- j. a4 l
disorganization activate neurogenesis activate oncogenesis   
' v9 I: I8 E. K' M2 K5 O2011-12-22 23:38' w! [2 O" N* U$ G
MSC is cell feeder，tissue scaffold，immune firewall and biological glue
7 ?3 I( m  n% i8 Y' x2011-12-19 19:46
; v9 w! {/ Q$ i- O% ^5 |( Acancer is Noah's Ark（species carrier and life explorer）
6 f6 u4 O" u" B# T$ e2011-12-10 09:46
# ?4 n- p$ ]: @3 A) l2 a$ Pcell fusion create new species, gene mutation induce variation
& o- u; h9 v2 w" {4 o0 E! y2011-12-10 09:363 r* \  h# |, I- e# w& t
GVT will be cancer terminator， Cytokine storm will be cancer preventor( [0 A; W  V* G& w. x: [1 x* O  M/ J
2011-12-8 12:56" ~. M6 K5 R; a
cell fusion results regeneration，reprogramming，neogenesis，atavism； cell division results differentiation，apoptosis，senescense，development;! e  R1 T& v9 p5 Z2 U
2011-11-27 14:54+ I$ @' l3 I: m
Cancer is between protozoa and mesozoa， not metazoa...
% t# h& j2 D9 r" n3 B) _2011-11-27 00:25- x5 n1 S4 Z+ R2 \
cancer is neurological disease！ haha，I got it！: L' E* I6 n* B4 {
2011-11-22 22:06
7 l3 K5 S6 v+ f+ m" t/ Vyou are cancer，fetus is tumor. 佛曰：汝既是癌 癌胚如来
/ G6 p5 W* B8 M4 r1 Q$ a2011-11-12 11:27
- Y6 f" H3 T7 k8 k0 N/ icancer is the ecological invasion of hacker.../ F9 X3 G8 ~& E, o% y/ d
2011-10-5 10:31# X) a; L, T: c3 }' v
microRNA is  negentropy？
2 \, @$ D, I, ~6 o  n" A2011-9-24 00:48' P5 ~5 |0 h( X( q: V+ n
cancer is the social problem7 I- f, y- y  Y7 q
2011-9-9 23:33
8 ~" I2 z" Y/ ~3 |! n" N8 ?Science is the games of nobleman or madman
: f( M; t( b. X2011-9-2 15:03
2 i  L6 p4 b1 R8 x2 d( S1 ]4 E: w/ u+ Lcancer resulted from disturbance of biological liquid crystalline state of ECM7 b* l+ @9 C1 K
2011-9-1 20:13
& I5 a; g6 n( C7 P1 Uniche n-dimensions——space, time, momentum and entropy; energy, material and information flows; physical, chemical and biological factors；topological, thermal, and fractal influences...7 f+ c# @1 l7 _; w
2011-8-13 00:377 o2 q1 _# |  p9 U
Second recession is coming？+ f, K! D; x6 X$ m3 ?4 l6 }
2011-8-9 23:58+ F8 W: i: Y7 G4 e6 e. x
cancer may be from sexual reproduction of somatic cells.& g1 |  u5 S. [* b) r2 P
2011-8-7 00:168 g8 [. p# t. w- i' m
who determine gene？ genetic determinism is fatalism！
5 F: \5 m, ^. z( l3 [6 T: x2011-7-30 11:26
# S9 }. ~) o3 Wniche reprogrammabllity is the key of solving cancer problems...+ t1 C4 c2 F" q
songtianlong: i can't agree more!!!O(∩_∩)O~ (8-14 20:42)2 Y$ t* _+ ^( `4 F
sunsong7: hehe. thanks for interested in this topic, welcome future discussing (8-14 20:54)& B3 q7 G8 b2 d
2011-7-24 01:246 x8 C! ~3 @0 z4 q
cancer results from acquired genetics alterations.
- L$ y+ c. L, f2011-7-20 21:37% n+ O4 E$ e% t8 L& v4 X
CSCs are the low differentiated cancer cells in G0
* H  w: V- w( o- i" _2 H9 [2011-6-29 16:306 ^4 {+ _- B- F# D* n: u
iPS future——in vivo direct reprogramming ...
: ^% `( ]9 F( ?. ^2011-5-31 15:20
% @; ?! {6 Q' l: ?, D1 e$ ?niche reprogramming——cell fate will be manipulated by cytoplasm - microenvironment interaction http://www.stemcell8.cn/thread-40755-1-1.html
7 c5 v7 {1 h' ~% m) y' R. H& {2011-5-31 01:28- a" T/ o4 R. G( T& q
all the somatic cells of Mammals are totipotent ！+ K3 o/ S; Q( T+ n
2011-5-22 22:22# Y7 L; x0 K4 h3 ?% F" z6 p
miRNA——The manipulator of  cell fate！
4 K" u2 }9 F. G0 ?( H2011-5-20 20:21: I+ i3 ?9 b4 j( z: j
《Cell Stem Cell》means “cell is stem cell”   活细胞就是干细胞？
# H3 `/ g& d/ }+ c  v2011-5-17 12:38  p  Y1 z" f+ |( J- i2 V' o  d
cancer —— good nuclear in bad cytoplasm！RNAs are cytoplasmic determinants determine  cytoplasm determine cell fate！ division is differentiation is cancerous is life ！
7 i+ K* s% r; ^2 M8 w% I2011-5-11 12:31. Z9 Z+ I% v7 p5 N9 T
cancer results from cell dedifferentiation...
! S  Y. `8 ?/ u& @2011-4-28 18:07
9 n! E7 Z( k0 u' @differentiation——asymmetric cell division ！
4 d3 y: R7 [% `" i. j2011-4-28 18:04
, ^9 x5 v. X: d" F8 o) gcancer origins from the regenerative cells！
; D6 M% t( t& M1 ~2011-4-28 17:52
4 J6 z5 D0 q. f& I) ~Proliferation is differentiation potentiality！8 z) B/ Q8 K3 A
2011-4-28 17:49& K% D* d0 M( b6 J9 p
iPS——the key of Pandora box！
) p5 P7 Q6 l( R9 O% H& g3 c6 N# s$ _2011-4-27 22:36
# Z# s1 T$ h( M% ~$ X4 o; mAristotle— "The whole is greater than the sum of its parts."4 W5 T+ W8 E( r- _) [) W
2011-4-27 00:20  N- v# b( S, L5 |8 r+ v
cancer——atavistic cells2 \3 O( j$ y! A, e; H! ?9 w
2011-4-20 00:20( m& U8 V; b$ v1 L' h: K5 Y
cancer——cellular atavism！
( ^4 ^; Q3 c& f0 _. k# r2 j2011-4-20 00:18
$ Z6 F. `8 _1 z7 Wcancer——evolutionary ancestors of mammals.' o$ F1 h0 H2 f. G4 n
2011-4-20 00:09, n+ g0 X' \7 ~
肿瘤是细胞自组织缺陷的产物 
+ p0 \( r1 C2 S2011-4-17 01:41( C0 o: p$ \5 l# t
cancer——Metazoa 1.0
" k5 X* V" M' z6 [8 v! w) Q2011-4-17 01:00/ Z" }* z0 J% C' ~5 t/ ]- a
US——the Axis of Evil！
- I/ L0 p, {! d3 f* u( c, l4 A2011-4-4 01:19
  j: K! U$ z; r' W美国是世界的邪恶轴心！
+ E2 A/ G" `9 A( rsunsong7: 沁园春.血               ---作者：萨达姆   日 本 风 光, 千 里 地 震, 万 里 海 啸。 望 仙 台 内 外, 废 墟 莽 莽； 东 京 上 下， 顿 时 逃 逃。 核 站 爆 炸， 世 界 惊 涛， 地 震 海 啸 试 比 高 ... (3-22 21:25)
. F( ?' i, E8 D# r* e1 y4 c2011-3-22 19:06- c+ m) e8 l7 ~3 H3 @, }
teratoma is derived from endogenous iPS！7 k( Z3 [% w/ Y, }* H
2011-3-15 21:441 u" S2 a& h7 B: r7 h  Q  A1 i
ips is a luxury gambol on  . p3 Q6 N/ h5 B/ a9 _+ D
2011-3-3 14:50$ }# T' I6 C! e0 Q5 j; p" e' S# X9 @
cancer is intermediate of species evolution1 _6 f1 g* ~+ `0 {
2011-2-12 12:29( E/ k& A5 L; w: \0 K9 b
stem cell now is on the eve of coming medical revolution3 k8 m4 ?$ v! ?9 G) i% V0 @: |
2011-2-12 11:20- m: Y5 D8 O. z( V
Inflamation is the reprogramming process of somatic cell in vivo！+ q! h  w9 d9 d: q1 U, R) [
2011-1-31 14:499 L' w. G& }# C
so-called medicine is niche regulator！) C& E! A" ^% o/ a- j8 V
2011-1-23 21:45
/ r+ g. ~% e! R8 @9 U0 `endogenous iPS is the cancer initiating cell！2 ~* n% p8 ?/ I; ^! h4 j
2011-1-17 16:47
, W$ J+ ]- P9 \; z1 O! O* ?cancer is unicellular organisms！
  m+ u( E/ Y* P7 c2011-1-9 22:040 H- n. S7 C0 f% b  a! t( s" W
Pandorabox Has Been Opened9 W- h1 j  J& s, }
2011-1-7 23:24
6 n6 ?) e; k0 @' D) M- q6 ]8 ciPS is the Emperor's New Suit ! 0 ]6 }# r0 }/ K! H, e) T: `$ s
2011-1-5 23:50  D! g# S- L( A. O* X7 E6 Y
cell-free is the final solution of stem cell therapy
# x! ?! k  j; h0 x0 @. C7 f2011-1-5 21:460 W7 B  S& j- A2 @6 A" u
niche is telling the story of stem cell...
: \/ A: b1 E* q7 ]8 ]" {4 `8 m2010-12-29 17:32
# d) w, D- `( G+ F' M9 {$ }0 \cancer results from reprogramming of somatic cells
; r* X" J: r: P; L6 A9 w; w2010-12-25 18:56
4 W" {2 i8 w. e6 p6 \cancer——good cells in bad niche！! d/ C: T+ m$ f/ z
2010-12-25 16:02( Q4 a7 f! t" N3 ]
cancer无罪——制造产生罪犯的土壤才是真正的犯罪！* w6 _1 G& [& |9 r3 {( C2 J
deron: 灰常同意，有相关文献么？ (12-19 09:41)
4 F. o( c* f7 w' ?* c2 b! h% ]" fsunsong7: 呵呵，请来参加讨论——癌细胞的发生可能是一种“返祖”现象？ http://www.stemcell8.cn/thread-32073-1-1.html (12-19 11:33)0 Z- ]4 e4 @7 U( j
sunsong7: 问题讨论 http://www.stemcell8.cn/forum-re ... 709-pid-246202.html (12-19 13:29)( ]9 F* p+ E' A  m
2010-12-18 15:54
/ K* N& w  O" v: y; K8 O子曰：上善若水 大成若缺——干细胞治疗的终极解决方案将是不移植外源干细胞！
2 Q; \! t6 _& s( o* |: j- q/ d2010-12-15 15:07& r* i* @, b, U* K4 {2 f" y0 d
老狼的记忆——大洪水
; K$ p1 `7 Q, [+ o  W6 R2010-12-13 23:25* B9 p" D7 B8 H3 v9 C
can cancer randomly differentiate into norml cell in vivo  
4 q5 g% M" D2 y8 R% f" j8 h2010-12-13 22:33
/ @: v: ?  N1 y+ u; b% o6 tomnis cellula e cellula
) Y1 ?9 o9 a% K1 L2010-12-12 09:28
$ D# t% x! y% |" E1 }* yStem Cell ——The Origin of Disease7 [9 P% i0 o; E8 p  ^7 D
2010-12-12 09:27
1 F# d( k- e8 U- o, X' @% K( K$ k

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