老狼的个人空间记录

sunsong7

"genetic mutation" should be exactly as "gene self-editing", X5 p) a/ R% [. }) g4 P& q3 S
2017-12-1 13:17
" X; z0 A" M9 N2 q( J0 A5 NBioreactor in vivo would be the terminator of illness.8 I, t, w5 u$ A& O
2017-11-20 23:09
$ V8 m( _" x& T. N' Brenew tech：剔除衰老（病变）细胞占位可以恢复青春。, f5 Q$ x2 v% J& p; r& v# s" L
2017-10-23 12:50
8 V) {# H6 I% w0 l6 C魔不疯，鬼不魅； 道非盗，仙非妖；神无形，兽无极。1 ]/ w6 O3 s7 f% D8 I& ^+ |
2017-9-30 10:58
2 B; v# h' R2 z0 w+ \& `# |Life 3.0——from decoding and coding to reading and writing7 E' g& G  O9 @; E
2017-9-21 22:32
& f; W. f, Z% k5 L* `' o理论创新：亮明立场——先颠覆，再完善- ?- d2 L$ f  D; K" E- L7 S
2017-2-7 00:075 B0 |+ P$ d, T8 }
干细胞第二定律：与细胞外基质共同构成多潜能；
. H- K) w8 B- g4 `4 ?" Q; y2017-1-3 11:14
$ Y) Y" @3 U* Q1 ?干细胞第一定律：全生命周期保持增殖分化能力；. S* H' s. ]- g* x# p0 ?0 q  [
2017-1-3 11:13) ?; m7 W! o8 D8 }
NgAgo——Never give A guideline operated！
$ D; {* U+ Z7 S# ]8 m7 Q- B2016-12-1 10:09$ J, ]- m  C* |5 V- d
表观遗传—— 一切皆可改变  一切皆有可能$ E9 V8 O  {& _- [/ K  c
2016-8-17 23:37( N8 R' z  y6 v, E
子曰：吸血鬼疗法——养儿防病 养孙防老
, C. ?2 B. q- y& l( B2 G2016-5-23 12:05
' C, k! l& v; _( Z4 p& HNgAgo——Debug tool kit for mammal cells
8 M4 X. ~. K0 p  }# U; A2016-5-9 13:09
3 v5 X" ^; \( M4 i: X: W9 T公理之外 皆需证明； 科学命题 皆可证伪。( |) F" y- N/ H+ b
2016-1-2 00:20+ m; A% D( I9 H+ R
低氧——破坏线粒体功能、诱发炎症、导致基因突变
4 U' ~  c' q5 y$ d& ]1 }7 T2015-12-16 20:19% R+ D- N+ p7 I" o- Z) m
癌症——炎症部位组织再生过程中细胞去分化失控形成的幼稚化新生物。7 p3 `2 E2 P. _4 M5 m
hcoohboy: 一个有趣的假设~但是没有炎症就一定没有癌症吗？ (12-18 16:16): ^" p8 \  i% _& F
sunsong7: 炎症与癌症同在，Hanahan D, Weinberg R A. Hallmarks of cancer: the next generation[J]. cell, 2011, 144(5): 646-674. (12-19 19:45)( ^9 t* j" f. p, I* c+ U
hcoohboy: 3ks~ (12-24 16:45)
; F: y. X8 V7 g! n. z  |4 U+ ~2015-11-18 15:54
3 d! @4 z8 x2 ?( E5 k抽象世界与客观世界的真理判别标准是不同的： 在虚拟数学世界里，逻辑是一切命题的唯一审判标准； 在客观物质世界里，证伪是一切定律的最终审判依据。
& }* Y( Y) E) O" T6 I/ c0 D2015-5-20 14:13
0 Y* H0 i, i/ I- d6 q0 j. A 传统生物学将死：进化论=自然神论   基因轮=宿命论   细胞论=活力论翻版。    现代生物学曙光乍现：系统生物学=数学 结构生物学=物理学 合成生物学=工程学
; y3 D' K. B8 C$ @helong: 系统生物学是把细胞、基因、进化、物理学、信息学（数学）、工程学等都打包起来的所谓新学科，目前只做到了简单组合，还没有达到系统集成阶段。合成学更多偏向于化学。 (4-21 19:28). l% t& F4 H! x7 t6 l- k
sunsong7: 方向对头，努力总会有结果的 (4-21 20:05)
% c: b! I/ D) l1 ?; Z" d; V1 z2015-4-21 16:46' X; N7 U7 x4 Z6 o# v! T
search and research is just disassembling the creature.$ A( a9 i4 }5 Z! S9 Z$ a
2015-4-7 17:01  `. p: b" w: R
selection is  the act of intelligence) H, C8 _; G/ j
2015-4-7 13:49! n/ P& D: q- _: }1 G; W+ _
Genome fusion create neoplasm
6 |2 R: d- B2 @4 I6 U2015-1-20 13:10
6 @% Z( v! q% S, l. ESTAP——Stupid Trick  Against Professional 
  d2 X8 C+ S4 ^" X; N2015-1-1 19:29" v; ^; b% E( b# a1 t
information=structure=negentropy, ?5 \  O: V# `, y( \
2014-7-22 17:369 I2 F+ I9 s8 e: O4 B& s
Natural mutation does not result in new functional genes 5 H; n5 l3 F& m) |; r3 [# @! B
2014-7-3 14:06
& H9 ]& a. L/ A8 o$ @' L( _life is wisdom creation instead of natural evolution& P$ |2 G5 @' m- F. E1 }: U) A
2014-3-27 09:337 i" H3 e! y6 j9 _# D
let us explore the source code of life !6 M+ r) F& t! P% k- m, T4 t
2014-3-11 13:11
/ q# y) U4 ~) }/ Bbio-manufacturing——processing，machining，casting，printing，3D prototyping，duplicating，cloning，life replicating.) H& `% w3 k0 X
2013-10-7 23:06
! u! _, P0 P& y7 L* m6 q, ]* Iinduced abortion would give the key for curing cancer 
$ W/ S/ B# w$ z! B& s2013-10-2 23:33
9 E# i. E; I& d5 R( q9 Y& s$ W“key breakthrough” in molecular biology are entertainments
/ g( M# [; j9 r0 i- p7 e4 z# @2013-6-16 11:50" R# v1 ?! L3 m0 f$ y% M( N$ P
Rules Of Living：trial-and-error exploring，survival takes the legitimacy% N/ T7 X& O+ \* E% B2 N
2013-6-16 11:27
; ?. {( P5 v4 {' VLife is a set of debuging programs
" ^+ w) q7 ]3 T% i: U+ p& V- y2013-6-15 18:40% h. w) D. C! }/ D/ ]& b; j& u" X
current biology is closed，destined and agnostic，it is  the only contribution is to kill cells( M6 D2 H$ c  g3 p$ {2 X
2013-5-2 08:541 |7 r2 {5 E+ B& F  }/ x  f) R
information，energy and construction are the new base stone of biology，instead of evolution，gene and  cell  tales
5 Y4 j. y7 U8 }. v2013-5-2 00:51
6 L8 \6 S+ S+ t0 A# g; |virus is the messager of  the universal life network
) |$ Y+ z% G  Q% l2013-4-18 14:33, w5 g. i+ B' z& X7 h$ W
Genetic information doesn't improve cancer risk prediction( m* Q- k; g' o
2013-4-1 09:20
+ F3 N$ {! U+ P3 x& C7 X2 GThere is no early diagnosis of cancer，but early prevention of it. w) u3 A- l& l$ i3 r! h  }+ B
2013-3-27 09:17
) Q0 D: u3 l  ^9 Zhypoxia maintains stemness or carcinogenicity
" @! s7 B% x% g" B8 L2 s% p2013-1-2 05:21
7 |" o7 N& }; x: Jcancer is the living fossil records on origin and evolution of human being
9 ~- O* N. l2 ?9 n' Z9 u2012-12-9 23:31
, P2 s  o" k3 Yinformation island results cancer7 s6 O; h$ m9 H* c, p  Y
2012-12-9 05:23
. P; [& ]  R. _life is digital game
1 Q7 w) C5 R! W0 K% Y- @2012-11-10 00:17
! I0 K9 I4 F  K- f5 rcancer ——severe abstinence reaction of cells to niche addiction& c# ]( C9 u( ]7 j
2012-9-28 12:11
% d( n" Z% x: U8 B未来生物学终将回归物理(熵)及数学(分形)的美感
9 l- R+ u) H/ e, U, Abiomater: 熵理论适用于任务物质。。。。也适合于生命 (9-26 09:28)
6 x6 ^$ V+ O: e- s  A2012-9-25 21:22
. a7 R6 y- i0 O2 f) ^# @0 kmembrane holds the key to life
* ^' n3 `4 ]9 {% ?6 G3 r) v) A# L" `/ _2012-8-19 20:24
0 [/ L& k# G, qCancer is the default state of cells; c, L. s9 P; s. {7 N
2012-6-26 22:178 N6 [) N" t: b( P( e
mainstream cancer theories could be overthrown！9 m. {+ u8 L5 v2 V7 F9 Y& i4 v, l
2012-6-25 15:43
- u& D- G4 c4 R$ B4 a' |. dcarcinogenesis has nothing to do with the gene mutations but is  the result of niche reprogramming...
) G1 Z# x1 l: n9 T' x5 H2012-6-7 09:36+ T% z4 I* M+ j, o) z, V* T
every living organism connected with the water， one cell one world5 ?/ R# p( F4 E+ y$ e
2012-4-19 22:06  z* ^* V5 \8 d' E( @4 h
chemical structure of cancer cell determines it's biological function...3 z8 ^0 b7 ^' t2 Q7 _4 z3 \
2012-4-7 17:56
9 y- U+ h6 w) n4 S9 ?) ]Mann tracht und Gott lacht
9 E2 Q0 r0 m* K& N( H* h4 k2012-3-24 21:34; ?' ~& y) F$ [) a' J- B: d. M
Darwinism or genetic determinism is a fairy tale！
8 v# Q5 s3 x! i$ z# c3 N# A2012-3-13 15:18
9 |3 n6 I/ V# p$ X; O# ?niche isolation is essential for cancer speciation- M* d4 s! L0 N6 O0 f
2012-3-12 12:07
! p  L. K' L/ V( g8 cHybridization Creates New Species，Mutation results species extinction2 x, N' k7 s! A+ M& s& a3 s
2012-3-11 18:21. a' N9 G* l$ e* B/ C! g+ C3 E
ROCK may join the niche reprogramming...8 G' K% T' n0 q7 |) `: @9 F/ X
yuhaoze: 这是篇文献吗？ (3-9 10:41)' B' n+ Y# D' s. \0 w+ l8 j* Z
sunsong7: http://www.stemcell8.cn/home-space-uid-6268-do-blog-id-1211.html 突破：病人体细胞及肿瘤细胞长期体外培养（附原文） http://www.stemcell8.cn/thread-51419-1-1.html (3-9 10:46)! ?4 f) w; ?  _( [; H
yuhaoze: 啊， 我看过这篇，还顶了呢，谢谢哈 (3-9 14:37)5 I2 A, q3 W# l: f# D/ M
2012-1-19 10:52
* ]" h' Z  I6 }) {oncogenes are pseudoscience
; }+ W& q4 N% V' G' A2011-12-29 13:554 a% P, E& q. B, |8 o$ o
gene mutation leads to variation or extinction, not new species
9 C% ?" T4 R0 r6 N$ }* j  V# D2011-12-29 13:28
- {9 k; G! f5 \; ]- d$ Yoncogenesis is non-Darwinian event* h8 ~* d+ R( K9 S: Z# m
2011-12-28 22:568 z/ A4 w3 u5 @0 o6 A: J- L
disorganization activate neurogenesis activate oncogenesis   4 P. ~2 J' i& l6 F
2011-12-22 23:38
' W) u: p8 A1 L7 r+ I# ]4 w$ OMSC is cell feeder，tissue scaffold，immune firewall and biological glue
& i- e, n% ?; n; A# R: u6 D2011-12-19 19:46
, P, U- @: `7 K$ j2 Q/ ccancer is Noah's Ark（species carrier and life explorer）+ J; U- Z( ~; J* N, V% Z
2011-12-10 09:46( \- A; t7 v7 Q% N2 _  y- U
cell fusion create new species, gene mutation induce variation
: j3 T9 `6 Z5 G) x4 F4 a2011-12-10 09:367 n# i  d8 s; g% h
GVT will be cancer terminator， Cytokine storm will be cancer preventor
" k  L. F: S& u) }: K. d2011-12-8 12:56
. ]+ ?2 o  ~& ~. y1 E* w( |  ?cell fusion results regeneration，reprogramming，neogenesis，atavism； cell division results differentiation，apoptosis，senescense，development;2 @2 r+ f0 u6 N0 @* `
2011-11-27 14:54
9 {  @. N. O0 WCancer is between protozoa and mesozoa， not metazoa...- R4 j. Y) i: W" w) R# h' {
2011-11-27 00:25& e! l: l2 R3 F# A8 [& K0 R4 R
cancer is neurological disease！ haha，I got it！
6 w! }1 _' H) q' _& ?, m: F+ D2011-11-22 22:066 ^) S: n% n& B, j/ N# ]8 Q
you are cancer，fetus is tumor. 佛曰：汝既是癌 癌胚如来" A" {% n$ ~. k8 {# z8 \
2011-11-12 11:27
- {& I: W  F3 N: ]$ B0 Xcancer is the ecological invasion of hacker...
7 Z0 G" o; y: _2011-10-5 10:31* ~9 K% O; A3 q; n" D; m- ?' K
microRNA is  negentropy？
' }3 @6 V( v+ m2011-9-24 00:489 E3 P! v4 E5 d$ U! |
cancer is the social problem6 \& t4 M$ S* c. ?3 r4 A/ l
2011-9-9 23:33
' o; e4 Q. h- D# C" U. [Science is the games of nobleman or madman0 b# X' V# x4 K9 p! R0 A! _
2011-9-2 15:03, [) ^" N* r. F9 Q% ~' u. \9 s
cancer resulted from disturbance of biological liquid crystalline state of ECM1 v1 y2 x: G4 E7 U
2011-9-1 20:13* ^( q5 H& M# I
niche n-dimensions——space, time, momentum and entropy; energy, material and information flows; physical, chemical and biological factors；topological, thermal, and fractal influences...3 B8 A  ^9 g, F6 f7 q
2011-8-13 00:37
+ p/ A# I: ^( e" o( rSecond recession is coming？
% i3 j1 v9 q0 |4 s1 g& Z2 G6 Q2011-8-9 23:58% D6 x- f' M, M3 |0 o5 D* r- t8 Q
cancer may be from sexual reproduction of somatic cells.
0 Z! ]4 A( K! d- z2011-8-7 00:16
# P$ n; j% h4 h5 O* ?. N5 Zwho determine gene？ genetic determinism is fatalism！4 u) T2 m+ y4 C, `
2011-7-30 11:26
* d/ [) J) T  b$ ]) O" hniche reprogrammabllity is the key of solving cancer problems...: |" `, ~6 x( \5 {
songtianlong: i can't agree more!!!O(∩_∩)O~ (8-14 20:42). b  D+ I0 ^1 j
sunsong7: hehe. thanks for interested in this topic, welcome future discussing (8-14 20:54)
1 V) Z( p: K: {  B& i7 Y! O. }2011-7-24 01:24
$ P- o! C$ |2 ]% N! @, N; I, Y- Acancer results from acquired genetics alterations.
! ~: ~8 G; H( z: O2011-7-20 21:37' B' L* D: R. ^) d* @$ R; s( `
CSCs are the low differentiated cancer cells in G0
6 f4 H4 k( e  H) p2011-6-29 16:301 W8 l* p: z( a! q) k1 @6 ^6 Z
iPS future——in vivo direct reprogramming ...
- [- V$ U  l' N; Q9 j3 I2011-5-31 15:209 {  P% X# x* @" @" l$ J# }
niche reprogramming——cell fate will be manipulated by cytoplasm - microenvironment interaction http://www.stemcell8.cn/thread-40755-1-1.html
/ q1 o# r; Z8 Z6 m9 ^2011-5-31 01:28
2 Q! ^) W9 A# {all the somatic cells of Mammals are totipotent ！% O+ `" I1 t  a
2011-5-22 22:22
& ]0 s7 b, X6 U0 L1 z/ RmiRNA——The manipulator of  cell fate！% T; S. x, \! E/ {5 _( ^; z- l
2011-5-20 20:21
/ M; K/ m% u9 Y8 F& V( \《Cell Stem Cell》means “cell is stem cell”   活细胞就是干细胞？
. J* K2 S+ H/ t5 P2 M5 u) s2011-5-17 12:38
+ |- j  R0 c! f' l. `3 x+ Mcancer —— good nuclear in bad cytoplasm！RNAs are cytoplasmic determinants determine  cytoplasm determine cell fate！ division is differentiation is cancerous is life ！
( ?9 F) b3 T" P# i9 f( ~9 k2011-5-11 12:316 T% ^& D9 A- X
cancer results from cell dedifferentiation...
2 P8 \4 f' Y; u) i) k1 x( A* x2011-4-28 18:07
2 k( G; ~% b  J7 z1 tdifferentiation——asymmetric cell division ！
" N. F" p1 r1 \$ w. Y2 ^) o; y& h2011-4-28 18:04: {0 J" [4 u2 X4 \
cancer origins from the regenerative cells！/ }9 v3 \5 ?/ m2 U! J: l0 P: P
2011-4-28 17:52
* R% x  \0 b7 f" c; cProliferation is differentiation potentiality！
3 N( @; y2 C* x" N6 ]# `2011-4-28 17:49
2 o$ `6 l8 R4 [4 liPS——the key of Pandora box！6 ]" }& C/ L  y& g2 G
2011-4-27 22:36. y: S0 m; Q- G$ M5 B% H9 z
Aristotle— "The whole is greater than the sum of its parts."
3 x+ [; q. l6 a, `# ^0 u- U2011-4-27 00:20. O& Z- e; R; }1 H3 g6 `/ o
cancer——atavistic cells
% H+ x0 V4 p/ N1 N- o' J2011-4-20 00:20- h& Y; V; A" c6 R' i0 V' e' ^3 [
cancer——cellular atavism！" O. ]1 T! ?% {7 f
2011-4-20 00:18* U2 `: `; U$ t, a
cancer——evolutionary ancestors of mammals.
: s) _, r" {& }  [) f; A+ N2011-4-20 00:095 m. p- A( Y. l; a) F; o* p
肿瘤是细胞自组织缺陷的产物 
' u/ A8 ~9 D$ p: K# q2011-4-17 01:41, ~5 Q6 E3 l  B0 B0 X
cancer——Metazoa 1.0  k# m4 M, _9 }# u
2011-4-17 01:00
9 [- E0 [$ B" Y! BUS——the Axis of Evil！# O: d% E5 G$ ?) q5 H
2011-4-4 01:19. o, N- W( C  P, k9 R
美国是世界的邪恶轴心！0 l; ]4 u* k5 u# w; r
sunsong7: 沁园春.血               ---作者：萨达姆   日 本 风 光, 千 里 地 震, 万 里 海 啸。 望 仙 台 内 外, 废 墟 莽 莽； 东 京 上 下， 顿 时 逃 逃。 核 站 爆 炸， 世 界 惊 涛， 地 震 海 啸 试 比 高 ... (3-22 21:25)
3 j) t5 G1 m1 v+ ]; n2011-3-22 19:062 p9 a" @9 v! X3 J% @& j
teratoma is derived from endogenous iPS！
  f# l1 a  @1 K  A9 I2011-3-15 21:44( k( K; A* c6 V, Q6 g5 O
ips is a luxury gambol on  
0 d9 h! k  r! X2011-3-3 14:50
) \1 J% J9 }. M* P* F! ^9 _0 tcancer is intermediate of species evolution$ p0 \3 C4 Z# w! {: g. `; z( i
2011-2-12 12:29& s. [1 u! I2 |+ Z7 k
stem cell now is on the eve of coming medical revolution. s- M/ I8 Z3 k5 F5 V2 {' p
2011-2-12 11:20, ^, g+ d! M; g* W# Q
Inflamation is the reprogramming process of somatic cell in vivo！
/ M% K* L/ B5 d+ O. t/ L2 z2011-1-31 14:493 P6 X& a% q0 E/ Q* m
so-called medicine is niche regulator！
) K8 w' i& ^- ~( b& l# p2011-1-23 21:45
! \5 w, b5 b5 N+ m3 Jendogenous iPS is the cancer initiating cell！
5 o) m" W, U: A3 G2011-1-17 16:47
4 w- B  C1 z$ D$ j5 A* xcancer is unicellular organisms！
0 E* f0 `- {9 ^4 @! B2011-1-9 22:04& B" q6 z; V8 _% _9 N$ l' n- m
Pandorabox Has Been Opened
" f. X& X$ M# {0 B* w; @7 I2011-1-7 23:24
1 v' W( |0 h5 f/ JiPS is the Emperor's New Suit ! 6 w7 H/ M5 E( A, ^
2011-1-5 23:50
& x& a' V, Z2 C+ ~- a# Xcell-free is the final solution of stem cell therapy9 {! @' {8 K8 D; T% f, i) [+ y3 }
2011-1-5 21:465 h- N. G% I. x- O
niche is telling the story of stem cell...
' x1 R. [' F- n1 Z, W4 [2010-12-29 17:32* J3 F5 F/ h: }( e+ `
cancer results from reprogramming of somatic cells- R! }1 W% V; ^8 Y+ {2 v
2010-12-25 18:569 L6 }5 [0 _% h
cancer——good cells in bad niche！
9 c* e- y0 o6 q9 X6 K& v8 b5 A2010-12-25 16:02
6 m7 @' [3 T" w  `! R& ?- Wcancer无罪——制造产生罪犯的土壤才是真正的犯罪！
, u. L' I5 o1 U$ {6 Y) Oderon: 灰常同意，有相关文献么？ (12-19 09:41)
; D) ~4 p: V2 W- }( i. qsunsong7: 呵呵，请来参加讨论——癌细胞的发生可能是一种“返祖”现象？ http://www.stemcell8.cn/thread-32073-1-1.html (12-19 11:33)6 ?9 q$ n9 S/ j0 n9 `- b
sunsong7: 问题讨论 http://www.stemcell8.cn/forum-re ... 709-pid-246202.html (12-19 13:29)# ?0 ]- @+ V  L4 E1 q0 o
2010-12-18 15:54
0 f5 L/ z4 ]; |子曰：上善若水 大成若缺——干细胞治疗的终极解决方案将是不移植外源干细胞！, V. ]! @( \7 }: ^; }% U
2010-12-15 15:07
7 c8 T6 ~( q8 Z, c9 ]老狼的记忆——大洪水
3 ~  V, J. y7 P* r2010-12-13 23:25; V- g: X+ B* q2 K8 S$ h8 ^0 b( _
can cancer randomly differentiate into norml cell in vivo  
2 ]% t! o( C6 {. F8 P' S2010-12-13 22:33+ Y+ L. k: L# ]8 z; m
omnis cellula e cellula
* M, _$ E8 Y6 K& i2010-12-12 09:280 }9 D1 z  ?% b8 R/ E6 Z/ z
Stem Cell ——The Origin of Disease
) j& e2 I/ ^4 |/ d& Z2010-12-12 09:27* J9 \3 c+ @3 P% [# u. |

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