老狼的个人空间记录

sunsong7

"genetic mutation" should be exactly as "gene self-editing"
) |: j8 R, E( {( D3 \! [3 y2017-12-1 13:17
, @  u0 \" f: p! ~! Q& A+ @Bioreactor in vivo would be the terminator of illness.
' H4 o4 W0 g+ E5 ^$ r. p# J3 v2017-11-20 23:09# t' e1 t" m$ y( M
renew tech：剔除衰老（病变）细胞占位可以恢复青春。
# m6 F) I: w, ~1 n2017-10-23 12:50: c7 o/ c. x! A% z9 B
魔不疯，鬼不魅； 道非盗，仙非妖；神无形，兽无极。
. j3 l3 i% T! x3 i2017-9-30 10:587 U% J/ M" Q- D0 o
Life 3.0——from decoding and coding to reading and writing$ ~4 U# {! x9 ]$ d0 f% H4 U+ g
2017-9-21 22:32
( l; J. m1 F; [8 h理论创新：亮明立场——先颠覆，再完善  }4 A) z8 l1 ^+ M
2017-2-7 00:07: L7 f% x9 D0 g# M: t5 y  Y
干细胞第二定律：与细胞外基质共同构成多潜能；
1 h3 H  O, _0 I- h0 N2017-1-3 11:14
" _$ ?- x3 S  K4 I干细胞第一定律：全生命周期保持增殖分化能力；
$ Y  j+ ?! `; p2017-1-3 11:13
! u% i% L1 U$ }4 ], v/ B) UNgAgo——Never give A guideline operated！# h& @  A8 I! ?0 X+ x; t5 t. W
2016-12-1 10:093 l$ U! B# K- u5 h
表观遗传—— 一切皆可改变  一切皆有可能" ~- e* ^5 ]8 u/ K
2016-8-17 23:37; `  j( ^/ p/ w6 h) m7 ^
子曰：吸血鬼疗法——养儿防病 养孙防老
/ n# D+ C) |9 `% u7 d5 p9 E5 d2016-5-23 12:05
! C, w% s) R" iNgAgo——Debug tool kit for mammal cells
+ _4 s; K) x, h0 E7 {2016-5-9 13:09# S: ^4 f( _" c; s
公理之外 皆需证明； 科学命题 皆可证伪。/ r7 V: m6 I# M% ^) J- D
2016-1-2 00:206 |4 B  f8 e7 Q3 T' G
低氧——破坏线粒体功能、诱发炎症、导致基因突变
" b( p$ ~. b+ M! R) E+ g' D: t; e/ D2015-12-16 20:19
/ Q: j) \  t7 L2 M  y) Q癌症——炎症部位组织再生过程中细胞去分化失控形成的幼稚化新生物。: E" }8 ]6 E' |
hcoohboy: 一个有趣的假设~但是没有炎症就一定没有癌症吗？ (12-18 16:16)
7 T8 N# w- r* }. O1 R1 I" vsunsong7: 炎症与癌症同在，Hanahan D, Weinberg R A. Hallmarks of cancer: the next generation[J]. cell, 2011, 144(5): 646-674. (12-19 19:45)% b2 X. D; j7 u7 R2 q) x
hcoohboy: 3ks~ (12-24 16:45)
* c* x6 O7 N$ L; _* Z9 C& J2015-11-18 15:541 H: _$ I5 z- g
抽象世界与客观世界的真理判别标准是不同的： 在虚拟数学世界里，逻辑是一切命题的唯一审判标准； 在客观物质世界里，证伪是一切定律的最终审判依据。. I( _! Q$ v+ [8 p) S
2015-5-20 14:13
3 Z4 q# E/ D, W2 \! X 传统生物学将死：进化论=自然神论   基因轮=宿命论   细胞论=活力论翻版。    现代生物学曙光乍现：系统生物学=数学 结构生物学=物理学 合成生物学=工程学
- W9 \0 K* c6 \4 ?helong: 系统生物学是把细胞、基因、进化、物理学、信息学（数学）、工程学等都打包起来的所谓新学科，目前只做到了简单组合，还没有达到系统集成阶段。合成学更多偏向于化学。 (4-21 19:28)3 |7 O9 j, x* ]6 ?
sunsong7: 方向对头，努力总会有结果的 (4-21 20:05)$ y! A: |! P& f+ r7 P! K0 J
2015-4-21 16:46( x+ t7 {2 N7 w, \- Y# O7 k
search and research is just disassembling the creature.
* x: d4 w* ]. C# {  {& ^8 J; T2015-4-7 17:01$ M- B/ ~9 Z" l- X
selection is  the act of intelligence
1 ]1 a4 w# J- R; s* v7 S( L2015-4-7 13:49
- K) a3 H9 h" T( @+ H0 vGenome fusion create neoplasm, ]  E; i1 p5 b5 M$ w
2015-1-20 13:10& e; n3 L2 b" w2 J  b  E
STAP——Stupid Trick  Against Professional 
( S4 k( c' u- ]2015-1-1 19:29
; B( f4 [0 H$ T8 J# e% rinformation=structure=negentropy4 w" @, D: o4 J( B1 ?5 x' ^
2014-7-22 17:36
# h% d, m" V1 H, C! O9 x; }Natural mutation does not result in new functional genes ; R; p& A# u+ b  i) R+ N
2014-7-3 14:06
; P% Q% F* i( e3 Slife is wisdom creation instead of natural evolution
3 H0 o( ~/ R2 H3 j2014-3-27 09:33# \5 ~+ o6 g' s/ k0 ?
let us explore the source code of life !
' y% E* Z7 f$ A. }2014-3-11 13:11: j1 A* n8 @* f- E2 I' W
bio-manufacturing——processing，machining，casting，printing，3D prototyping，duplicating，cloning，life replicating.: ~) x' a9 y- A+ J5 @8 o
2013-10-7 23:066 l0 ^9 u; R  Y4 x, [
induced abortion would give the key for curing cancer 
2 `8 m) X9 I. Q0 a3 w' o! g1 O7 b$ g2013-10-2 23:33/ s3 ]& G' ]8 |, M
“key breakthrough” in molecular biology are entertainments
- N  G' D! e8 }2013-6-16 11:50
6 p: C) x! K9 o4 y2 _. [Rules Of Living：trial-and-error exploring，survival takes the legitimacy6 p( `$ S8 }3 \! t
2013-6-16 11:277 a+ j. e* Z- d% F
Life is a set of debuging programs9 J2 {0 m$ x/ @6 a# c
2013-6-15 18:40
7 o7 Q) G7 g7 e+ g9 w" Rcurrent biology is closed，destined and agnostic，it is  the only contribution is to kill cells& f. m! _0 y/ q1 C
2013-5-2 08:54' e6 S  a: K+ Z- i: k
information，energy and construction are the new base stone of biology，instead of evolution，gene and  cell  tales/ x3 H6 u; k; W" R& `- K
2013-5-2 00:511 n6 d* A% I) n- L0 Y8 e
virus is the messager of  the universal life network
2 [& x9 ]. Z# z+ l. H9 b0 i( K2013-4-18 14:33
% ]: ~. B0 I/ T, lGenetic information doesn't improve cancer risk prediction  x# i) Q: w- q" C. `) L4 r
2013-4-1 09:20& `3 h5 [3 f6 T/ x
There is no early diagnosis of cancer，but early prevention of it
. K- v0 n+ a* Z( S  m2013-3-27 09:171 ^  V+ |9 N( d7 `6 Z3 H0 o
hypoxia maintains stemness or carcinogenicity/ o. t6 v$ V8 g
2013-1-2 05:21! z- U6 e  k% J) p
cancer is the living fossil records on origin and evolution of human being
- m8 k' ~+ b4 M7 L1 Z6 s2012-12-9 23:31
5 [" D  p& Z# J3 winformation island results cancer* C4 S8 `$ D" d
2012-12-9 05:23
) e1 z$ ?1 c4 z) _* k, y. z3 N" ulife is digital game
/ i0 Z* j8 X9 f; W$ x2012-11-10 00:17
% O& [1 T- E! s+ L& mcancer ——severe abstinence reaction of cells to niche addiction' ^  e# h4 E9 ~0 ^
2012-9-28 12:11' |, N4 i0 R+ x. B8 P
未来生物学终将回归物理(熵)及数学(分形)的美感& a/ ~9 l$ y. e7 [- G2 U  o
biomater: 熵理论适用于任务物质。。。。也适合于生命 (9-26 09:28)
4 w4 K# `- J9 v6 _, m2012-9-25 21:22
  W) Z& I6 ]+ V: _+ v! S$ |3 [% lmembrane holds the key to life
( f4 U$ u" [0 `* U! h) C2012-8-19 20:24" z. X9 m% r- Q1 l5 Y) g
Cancer is the default state of cells8 c# \: t/ [! ~
2012-6-26 22:17* J  W/ I' y) U1 C
mainstream cancer theories could be overthrown！
1 n& F5 x2 u" ~/ w3 ^' s7 R& s2012-6-25 15:43) D4 Y, s  a- i5 f  l* \  y
carcinogenesis has nothing to do with the gene mutations but is  the result of niche reprogramming...
! o* h" k; b! @1 _. g2012-6-7 09:36
  _* r* P& X* |; u. l+ s/ F' Eevery living organism connected with the water， one cell one world
8 e. N; h6 ]7 ?  k1 m/ G2012-4-19 22:069 q. S8 G/ ?1 w4 D8 o
chemical structure of cancer cell determines it's biological function...& k7 S" a. X! b/ f
2012-4-7 17:56" |1 e$ Y. }7 N% X3 t  a
Mann tracht und Gott lacht
! R) Y; n5 l& x' X* r3 Y1 \7 Y2012-3-24 21:34) {6 o4 _6 f9 y1 s2 b' \2 [, N
Darwinism or genetic determinism is a fairy tale！# Y" p4 e. @2 o/ ~4 u/ y- O
2012-3-13 15:18
, W: |5 f% m3 d1 ]# T' a9 Iniche isolation is essential for cancer speciation
; `* J' c# v) x3 x8 K2012-3-12 12:073 R9 Y; B! s4 W. ~3 {
Hybridization Creates New Species，Mutation results species extinction
0 ~* g$ F' o9 o6 k5 o6 g2012-3-11 18:21/ e" _, h( [; y, |1 p: k. c7 }
ROCK may join the niche reprogramming...
$ S( C; K4 D0 k6 ^" N: Qyuhaoze: 这是篇文献吗？ (3-9 10:41)
: a8 K! J4 J. R5 osunsong7: http://www.stemcell8.cn/home-space-uid-6268-do-blog-id-1211.html 突破：病人体细胞及肿瘤细胞长期体外培养（附原文） http://www.stemcell8.cn/thread-51419-1-1.html (3-9 10:46)2 I" K% y. A1 m! A
yuhaoze: 啊， 我看过这篇，还顶了呢，谢谢哈 (3-9 14:37)- n0 y% s1 v1 `( l; [4 {$ r
2012-1-19 10:520 d* h# `3 T% d* U. I
oncogenes are pseudoscience
9 x: p* {4 ]. T$ R3 x" T2011-12-29 13:55$ u. D# c6 D  Z- U# R
gene mutation leads to variation or extinction, not new species8 Q3 G: v9 {  [. ^
2011-12-29 13:28  c9 V5 G' D" C
oncogenesis is non-Darwinian event2 Z1 v& z) M: i+ l$ y- a# W
2011-12-28 22:56
5 S1 z4 [8 e* c6 Zdisorganization activate neurogenesis activate oncogenesis   
* e- G" \/ X# D2 l! N1 F3 _( h2011-12-22 23:38
! t% x9 e* Z3 LMSC is cell feeder，tissue scaffold，immune firewall and biological glue
7 Y: A+ r0 A* s2 ^& R  P; }2011-12-19 19:461 Z) V5 d& r" v
cancer is Noah's Ark（species carrier and life explorer）, w$ G  A# U5 {8 S( F9 m1 J: L3 U: Z
2011-12-10 09:46
) G9 \# p' Z6 P4 H5 Q# Icell fusion create new species, gene mutation induce variation
- t5 U% J8 R* M' [3 b- k2011-12-10 09:36* `: v7 r( e  x% Q
GVT will be cancer terminator， Cytokine storm will be cancer preventor
! i% T: [0 ?& i, o/ J2011-12-8 12:56
% P! b% q, r$ O* I: scell fusion results regeneration，reprogramming，neogenesis，atavism； cell division results differentiation，apoptosis，senescense，development;
- P/ B. L" g) M2011-11-27 14:54
3 j/ x$ T& F7 a& O; ~. k9 f. DCancer is between protozoa and mesozoa， not metazoa...8 ^0 f3 I  w+ w7 M; s) Z
2011-11-27 00:255 k. y! `: l5 B" O& q
cancer is neurological disease！ haha，I got it！
8 Z8 k/ v2 E* a" Q2011-11-22 22:069 W! u8 ~. @9 _2 U
you are cancer，fetus is tumor. 佛曰：汝既是癌 癌胚如来
$ B. d4 n+ i5 C/ K, F3 P% Q2011-11-12 11:27- c  C- A4 D. X2 ~; o; p5 \" x
cancer is the ecological invasion of hacker...2 y4 x% m, Y, ?+ U4 A6 C. b
2011-10-5 10:31
' O$ e+ b* M. B, |# h7 |: j. JmicroRNA is  negentropy？
2 U- W9 s& y- P- m& X) r6 R2011-9-24 00:48
( }3 }, `" x6 a' a0 ~: i8 r9 ocancer is the social problem
* F6 j2 n5 W& _- @" ]2011-9-9 23:33
7 d+ q) \2 y. o# L6 C4 e  IScience is the games of nobleman or madman# L$ q8 b2 V% u; q' g& R) t
2011-9-2 15:03
' @: e6 W9 o; _( c2 \' o; Ecancer resulted from disturbance of biological liquid crystalline state of ECM
1 N! J0 B' t& d1 _3 L& w) h* N. y2011-9-1 20:13
( o, `: J( j$ K- dniche n-dimensions——space, time, momentum and entropy; energy, material and information flows; physical, chemical and biological factors；topological, thermal, and fractal influences...
/ X+ G3 M+ G- i! Z2011-8-13 00:37
7 D9 M% K) W9 A, ~" O: DSecond recession is coming？4 a& ]/ L# d5 S, Z; z* t' g/ a
2011-8-9 23:580 R5 P, V0 [: X" c3 \0 l: f
cancer may be from sexual reproduction of somatic cells.4 |2 L% E+ q7 y+ |; a
2011-8-7 00:160 Q4 n; i3 L8 B3 M1 n& S- m
who determine gene？ genetic determinism is fatalism！
6 b1 C  P- h& \7 m1 I/ M2011-7-30 11:26' V( R) u- B" t
niche reprogrammabllity is the key of solving cancer problems...
: }) B+ P; b" f6 J5 G, g. j) gsongtianlong: i can't agree more!!!O(∩_∩)O~ (8-14 20:42)
; w- |2 d; z4 `) k5 S, H% ~3 msunsong7: hehe. thanks for interested in this topic, welcome future discussing (8-14 20:54)
! L# O  i4 R0 R* H- F2011-7-24 01:243 w. s& h) h8 R
cancer results from acquired genetics alterations.7 ?3 [4 _- s. h' O: h" Q
2011-7-20 21:37
; A1 t" ^& \: b0 v- D  q. qCSCs are the low differentiated cancer cells in G07 l7 J$ ~" H" ~6 A
2011-6-29 16:30. D: u1 c/ a. M, q" P8 u  G/ M
iPS future——in vivo direct reprogramming ...% E$ \, z# Z7 {' q5 p6 t$ w/ c
2011-5-31 15:20: y; Y2 h; f1 b! F
niche reprogramming——cell fate will be manipulated by cytoplasm - microenvironment interaction http://www.stemcell8.cn/thread-40755-1-1.html
" S7 o2 o% T! ?2011-5-31 01:28
# @! ?* j. r9 ?all the somatic cells of Mammals are totipotent ！
+ q% P2 ?/ c/ J2 ]- p3 ^7 O2011-5-22 22:22, B3 o8 I( @2 Y- m7 W- {- W
miRNA——The manipulator of  cell fate！. D+ T# \* n: m& q
2011-5-20 20:217 V4 h/ W3 r5 g# O$ R
《Cell Stem Cell》means “cell is stem cell”   活细胞就是干细胞？* P. i( d2 \4 X; L' O
2011-5-17 12:38
$ b4 k3 A9 ?1 H/ L( m' Scancer —— good nuclear in bad cytoplasm！RNAs are cytoplasmic determinants determine  cytoplasm determine cell fate！ division is differentiation is cancerous is life ！
) p" a/ D. h: r/ \3 q2011-5-11 12:31/ h3 J( k2 a; P8 T/ }% _6 |
cancer results from cell dedifferentiation...3 W- ?! h' ]! o7 b% O  P: J4 _
2011-4-28 18:079 c  J9 v, g: Y# |$ r8 V. q
differentiation——asymmetric cell division ！
+ ^. A7 `2 z/ `9 Y3 Y' G2011-4-28 18:041 H; J: A/ W& U
cancer origins from the regenerative cells！% Q6 z9 M3 I" o0 `' U( e
2011-4-28 17:52# Y7 y3 b8 w* a* C/ @2 I/ s% u
Proliferation is differentiation potentiality！
/ ]& ?. N5 j3 E$ m. b2011-4-28 17:49
7 @7 o4 [8 b, Z- R) }$ N$ e: A0 BiPS——the key of Pandora box！/ R! ^$ Z1 X- v# C' G% I
2011-4-27 22:36
5 w3 h, a4 W3 f  SAristotle— "The whole is greater than the sum of its parts."
8 L# U" E1 O% ]3 T# i2011-4-27 00:207 a% W& O+ t  c4 o$ O6 T4 P
cancer——atavistic cells
6 r" l( D+ |1 a! B( s2011-4-20 00:20' j8 S* A/ p0 k! N$ m
cancer——cellular atavism！" n" X0 B$ C1 `5 M1 y$ E$ A& ^/ v
2011-4-20 00:18
' C# g: z! f5 lcancer——evolutionary ancestors of mammals.
& ~9 N" }; g, ?0 }2011-4-20 00:09( `. n; U4 M% F4 G% ~
肿瘤是细胞自组织缺陷的产物 $ `1 |; k0 x! b+ @, k) A
2011-4-17 01:416 o7 C9 m/ f* u1 k
cancer——Metazoa 1.0; ?/ }- E$ O$ Q# }
2011-4-17 01:00
7 K2 j( j3 J7 n% R& ^US——the Axis of Evil！2 h! r2 b/ O3 V/ y) \
2011-4-4 01:193 P0 d( C1 e: x$ c
美国是世界的邪恶轴心！
9 e8 _" R& f6 M! z" Fsunsong7: 沁园春.血               ---作者：萨达姆   日 本 风 光, 千 里 地 震, 万 里 海 啸。 望 仙 台 内 外, 废 墟 莽 莽； 东 京 上 下， 顿 时 逃 逃。 核 站 爆 炸， 世 界 惊 涛， 地 震 海 啸 试 比 高 ... (3-22 21:25)0 P5 {' ?& s9 t% E- {/ {' \3 b
2011-3-22 19:06. Z& W4 C- k' j: l5 G. [5 e
teratoma is derived from endogenous iPS！
& a- t/ r  c" m! b0 Q3 M3 I/ ^2011-3-15 21:441 {- ~+ D0 N. w7 K
ips is a luxury gambol on  
  f0 e4 h4 L& u% g2 ]/ P. N$ O0 S2011-3-3 14:50: c$ c! _: O5 q# E$ U' n7 |
cancer is intermediate of species evolution
5 Y3 Q+ S% T* |  K' `7 ?2011-2-12 12:29
6 J& M0 \3 L3 C- `" B/ X! tstem cell now is on the eve of coming medical revolution
- s' d5 u: l" J& X; b9 l4 M& j2011-2-12 11:201 ?  ~3 e& A( }+ n* z4 B. }# k4 {6 h' m
Inflamation is the reprogramming process of somatic cell in vivo！
" ?+ w& c8 T( C0 R* m2011-1-31 14:49, M2 x/ a& l) y/ N, \( Z
so-called medicine is niche regulator！! O% I9 s$ ?* O
2011-1-23 21:45* @4 w9 ]1 |9 }$ S
endogenous iPS is the cancer initiating cell！  `* U9 m1 R9 m4 X5 @$ ]# z, \! \
2011-1-17 16:471 W" P7 `/ P1 V1 `4 W6 S+ V
cancer is unicellular organisms！0 V" c" W  A# `) K4 r
2011-1-9 22:04
. \7 f! U" b4 }" s  Z0 zPandorabox Has Been Opened. Q: G/ K6 ]8 g$ X
2011-1-7 23:24
6 j" K5 e5 \% |* [; M, xiPS is the Emperor's New Suit ! 
. b8 c2 D' o+ @2011-1-5 23:50
" n: q  Z' |" C# o6 ucell-free is the final solution of stem cell therapy
1 l- m5 e& B0 a* s# A2011-1-5 21:46
( O9 B1 `" {3 n7 B. F, H; Bniche is telling the story of stem cell...* A* G$ W& L2 d2 _
2010-12-29 17:32
8 p5 [( \3 X# ]8 bcancer results from reprogramming of somatic cells" ?, N4 i- k# {  f  h$ K" t! J; _
2010-12-25 18:56
4 L" E2 G/ F: F) |0 b6 J+ ccancer——good cells in bad niche！5 ?4 s% d& Z3 F: U
2010-12-25 16:02. @  ?! ~+ u4 J8 s9 a
cancer无罪——制造产生罪犯的土壤才是真正的犯罪！
+ v" c, ^9 y/ tderon: 灰常同意，有相关文献么？ (12-19 09:41)  J9 R+ w3 v7 m. g' w
sunsong7: 呵呵，请来参加讨论——癌细胞的发生可能是一种“返祖”现象？ http://www.stemcell8.cn/thread-32073-1-1.html (12-19 11:33)% [- z. j* q3 z4 ]
sunsong7: 问题讨论 http://www.stemcell8.cn/forum-re ... 709-pid-246202.html (12-19 13:29)
& A6 }! _+ [; ~" l7 t0 K6 k2010-12-18 15:54
' \4 W/ j# R2 m9 V' `# R子曰：上善若水 大成若缺——干细胞治疗的终极解决方案将是不移植外源干细胞！
5 G/ R. d5 y9 S  D& S1 [$ z2010-12-15 15:07
! D7 J; u/ i4 Q: ^# N! F9 v老狼的记忆——大洪水, j4 i% K  V9 e4 z
2010-12-13 23:255 ?* m( M5 R7 c
can cancer randomly differentiate into norml cell in vivo  ; N) P% F: t& D( R9 W
2010-12-13 22:33
, k! \; G( k: W( Komnis cellula e cellula) [* ^% Z9 x( L$ u6 i
2010-12-12 09:28* L- F3 ]* G' R; P2 O
Stem Cell ——The Origin of Disease
* O- X$ D7 x0 H5 _! ?5 x# }2010-12-12 09:27
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