老狼的个人空间记录

sunsong7

"genetic mutation" should be exactly as "gene self-editing"
, C% w3 t( ^5 l# I2017-12-1 13:17, K3 O- U7 c+ e! W( h
Bioreactor in vivo would be the terminator of illness.
; E2 q6 h( [+ Y5 T1 \2017-11-20 23:09- t4 i) V) u8 f( `/ n+ q7 ?3 @
renew tech：剔除衰老（病变）细胞占位可以恢复青春。# F1 y6 r. N# |! [! X' }
2017-10-23 12:50
, w4 L/ f8 l4 b" J! m魔不疯，鬼不魅； 道非盗，仙非妖；神无形，兽无极。9 `' |9 o( i+ q2 K3 i" A9 B2 n/ J0 S
2017-9-30 10:58
5 w2 K$ _% r. `- ~: mLife 3.0——from decoding and coding to reading and writing' a: {7 k: b& h/ l) e4 l! x/ r
2017-9-21 22:32' P6 j- E: r( q% V+ z' d0 O
理论创新：亮明立场——先颠覆，再完善& U/ V; d, s* V# U4 P$ _7 d
2017-2-7 00:07% V0 l6 d+ B. U
干细胞第二定律：与细胞外基质共同构成多潜能；; a1 I, r. A# @: p3 }+ s
2017-1-3 11:14! I. ?7 H. t0 ~5 d% B7 o
干细胞第一定律：全生命周期保持增殖分化能力；
7 ~, y8 t. Q# C! ?2017-1-3 11:13" V9 b, q2 n) x& J% |/ V! N: b' N6 c: z
NgAgo——Never give A guideline operated！- n  @9 E$ ]" Z# N6 L' U7 k
2016-12-1 10:09
# F5 C, y% h' N( d% y" y表观遗传—— 一切皆可改变  一切皆有可能
3 ~! n: I5 u) |5 l! L% H2016-8-17 23:37+ b5 h: X, ^5 z3 I
子曰：吸血鬼疗法——养儿防病 养孙防老
. H4 s, ?+ ]4 ]$ y% |2 _2016-5-23 12:05" r  n4 B# E5 j& l$ U# X; M" }
NgAgo——Debug tool kit for mammal cells: I6 G& N/ S& y$ d' x+ z% R% v
2016-5-9 13:09! j. y( G; \  U& A) T0 }
公理之外 皆需证明； 科学命题 皆可证伪。
* i5 d- F! W2 f( E& ~7 p2016-1-2 00:20
7 F+ V% p, u" H9 ]低氧——破坏线粒体功能、诱发炎症、导致基因突变7 f* i& ?  g8 t2 M/ g! [& t3 d) p
2015-12-16 20:19
1 ^' k! m* ~5 l1 f. ?4 B癌症——炎症部位组织再生过程中细胞去分化失控形成的幼稚化新生物。3 r5 e, `3 @5 k) n& T+ \
hcoohboy: 一个有趣的假设~但是没有炎症就一定没有癌症吗？ (12-18 16:16), W, n( L  O$ B, @* V' L
sunsong7: 炎症与癌症同在，Hanahan D, Weinberg R A. Hallmarks of cancer: the next generation[J]. cell, 2011, 144(5): 646-674. (12-19 19:45)! ?0 E; D$ N+ B' z0 b" ^0 ~
hcoohboy: 3ks~ (12-24 16:45)0 [5 D, _( f, a( I
2015-11-18 15:54
& L8 O' Z, v4 _抽象世界与客观世界的真理判别标准是不同的： 在虚拟数学世界里，逻辑是一切命题的唯一审判标准； 在客观物质世界里，证伪是一切定律的最终审判依据。
/ A/ Z$ Q% [$ }$ P3 X2015-5-20 14:139 e2 M8 T* a1 ?: n
传统生物学将死：进化论=自然神论   基因轮=宿命论   细胞论=活力论翻版。    现代生物学曙光乍现：系统生物学=数学 结构生物学=物理学 合成生物学=工程学; t2 |2 B* }& x) {/ e2 L
helong: 系统生物学是把细胞、基因、进化、物理学、信息学（数学）、工程学等都打包起来的所谓新学科，目前只做到了简单组合，还没有达到系统集成阶段。合成学更多偏向于化学。 (4-21 19:28)
+ p: f3 y3 y3 ~, j9 `sunsong7: 方向对头，努力总会有结果的 (4-21 20:05)/ B7 f; b, h0 C* M
2015-4-21 16:46
" a7 D/ _' O! \! L. d* ]# bsearch and research is just disassembling the creature.
: G! l7 j0 [) U# H2015-4-7 17:018 |0 F- G6 ?) |8 `+ r, D  M
selection is  the act of intelligence
8 q5 @6 B* |' w( t2015-4-7 13:49. M+ E, R7 r* c+ s
Genome fusion create neoplasm. ~( S: l8 g, S
2015-1-20 13:10
( S0 J$ y1 g8 x  X) R. h! xSTAP——Stupid Trick  Against Professional 
; f- |; i' g' K( E7 t2015-1-1 19:29
# ?) w! p( T: W; u3 linformation=structure=negentropy
3 m' P+ p. a4 i& J, }/ O8 a# X2014-7-22 17:367 X7 k& j4 V2 A4 w
Natural mutation does not result in new functional genes 
1 ^7 t5 w' E7 t/ Z2014-7-3 14:06' ]+ c$ I9 g% R$ I+ `% R3 B
life is wisdom creation instead of natural evolution
1 M5 }( }/ a3 Z0 E2014-3-27 09:33
, k" E  O4 E' Klet us explore the source code of life !" X+ k- N! N2 X" c
2014-3-11 13:11; j$ T% f& P/ \2 \# _) z3 ^- \7 L
bio-manufacturing——processing，machining，casting，printing，3D prototyping，duplicating，cloning，life replicating.$ p6 a5 Z" R  ~% Q  N9 a+ i/ ^
2013-10-7 23:06
4 i5 d8 E+ f3 b, e2 W5 \induced abortion would give the key for curing cancer ; D$ G1 \( j4 Q! R% ?! `
2013-10-2 23:33
0 N% ^6 c2 I( A; _% M1 x5 Q: p“key breakthrough” in molecular biology are entertainments0 q) h) @# h- m; T0 t
2013-6-16 11:50: x9 d5 D4 |3 [
Rules Of Living：trial-and-error exploring，survival takes the legitimacy
' c8 E4 k. A) O( R  A; C8 ^2013-6-16 11:27
5 Q; o! D. D: `2 I' G0 l3 F/ K2 yLife is a set of debuging programs# |( [% Z4 {& D/ D, v
2013-6-15 18:40
; ]* ]. Q. L  b7 T) Q; y, tcurrent biology is closed，destined and agnostic，it is  the only contribution is to kill cells
, w8 h3 r% `/ C0 v; z6 P- B/ A  Q1 `2013-5-2 08:548 m9 I, S, r* ?8 i  F. `
information，energy and construction are the new base stone of biology，instead of evolution，gene and  cell  tales$ P, I" n& G- \1 w  ]* W6 B
2013-5-2 00:51
! v  s8 O1 L% f0 y% Y% h. bvirus is the messager of  the universal life network
* D8 G3 H9 ?  T0 U3 E2013-4-18 14:337 \7 I, a6 {& }2 D
Genetic information doesn't improve cancer risk prediction
( b2 Z7 Y  k+ |2013-4-1 09:20
0 y! R6 b: [7 N4 U; }& iThere is no early diagnosis of cancer，but early prevention of it
& Z7 g- E* b' `. M2 P2013-3-27 09:17
; c/ H. R% {+ ?hypoxia maintains stemness or carcinogenicity% k" W- \$ l2 _( I6 c3 W! l
2013-1-2 05:21
, r0 h& N3 X) t; O1 N$ Zcancer is the living fossil records on origin and evolution of human being& I( E$ D8 |# R7 |
2012-12-9 23:31
" T, q3 P- e; t' R) U8 z* s# J, }information island results cancer
( ?8 i8 D5 I$ e5 v5 c) }- N( u2 M2012-12-9 05:239 o% }$ x' M# Q
life is digital game
2 l6 H. J) M2 D2012-11-10 00:17
! Y9 k% n/ }) h7 M6 F0 W& v( wcancer ——severe abstinence reaction of cells to niche addiction
; g6 `2 x5 f5 E4 c4 D2012-9-28 12:110 F' p/ m0 J! n, w( L
未来生物学终将回归物理(熵)及数学(分形)的美感
, T: ~+ i# F+ W* Cbiomater: 熵理论适用于任务物质。。。。也适合于生命 (9-26 09:28)
/ O/ R. O' r9 P* U, [2012-9-25 21:22
$ t% E2 i2 \  w% u4 `membrane holds the key to life! J+ ~* A) Z+ n2 I! }5 Y
2012-8-19 20:245 ~1 i1 T5 W9 E9 B  C2 e
Cancer is the default state of cells
3 Q5 F' O; e5 }- y# {2012-6-26 22:17
/ \3 @; G7 \- Z/ x, b. E" Emainstream cancer theories could be overthrown！2 p, ^9 q0 k9 s: `, k
2012-6-25 15:431 u4 J8 s$ J3 p$ s% n' ]
carcinogenesis has nothing to do with the gene mutations but is  the result of niche reprogramming...
' X# z5 r: J; [' w5 C0 [2012-6-7 09:36
+ M+ ?  j+ ?! I; d/ h5 U8 a1 Yevery living organism connected with the water， one cell one world
: D2 v! m/ h3 }* C( B3 ?; A2012-4-19 22:06
8 n9 A, ~- o2 M. fchemical structure of cancer cell determines it's biological function...) _# Y# F; _8 k6 ?) i- e
2012-4-7 17:56
- d4 T2 c" n+ i2 PMann tracht und Gott lacht
" ^/ \1 y& g/ l! l5 {2012-3-24 21:34
# T2 ]# v* h$ zDarwinism or genetic determinism is a fairy tale！3 y) o2 V/ T6 U; B
2012-3-13 15:18
: F6 y# L" o# g  f* r! Iniche isolation is essential for cancer speciation6 k( \: O% ~/ Z4 d9 r
2012-3-12 12:07
" E( C4 M# p( a: n' SHybridization Creates New Species，Mutation results species extinction8 w  Z% ~# r" _* e& J
2012-3-11 18:21
# u6 d6 O. [/ @8 C  NROCK may join the niche reprogramming...
+ S8 @6 g7 F- G& u" nyuhaoze: 这是篇文献吗？ (3-9 10:41)
2 e- N9 f2 M/ u% y  Esunsong7: http://www.stemcell8.cn/home-space-uid-6268-do-blog-id-1211.html 突破：病人体细胞及肿瘤细胞长期体外培养（附原文） http://www.stemcell8.cn/thread-51419-1-1.html (3-9 10:46)2 `# e; Q0 ]/ S
yuhaoze: 啊， 我看过这篇，还顶了呢，谢谢哈 (3-9 14:37)
  K+ D: m7 G8 C2 i. a' A: _3 [2012-1-19 10:52
. s/ E/ \; |4 Poncogenes are pseudoscience
. x8 I7 I6 }* B( e, D2011-12-29 13:55
4 w. l* E2 ?6 }! m8 N# ?- ~9 x0 y/ F+ @gene mutation leads to variation or extinction, not new species2 l' T: U6 \% b1 f1 m& ^
2011-12-29 13:28- |4 D1 k  R) Q& q- @8 s/ N! P
oncogenesis is non-Darwinian event4 I  c+ a$ i3 U' E* Z$ \: m
2011-12-28 22:56
( m0 a* q5 Q2 x* K0 \# ~3 J- a3 ydisorganization activate neurogenesis activate oncogenesis   
3 ^: h# E' t% P  r& J+ `7 T* e2011-12-22 23:38, w$ f0 j7 Q/ a, `& {: d/ ~
MSC is cell feeder，tissue scaffold，immune firewall and biological glue
' }, t) V/ e/ [2011-12-19 19:46% O( J1 R% N. G; x
cancer is Noah's Ark（species carrier and life explorer）
# @" Z. P. B: K/ y* ~3 I' c: L2011-12-10 09:46
! ?/ }* Q" F2 {cell fusion create new species, gene mutation induce variation
9 y0 C5 m) ~! G$ l1 W9 M9 Z9 \% ^2011-12-10 09:36# p( ~/ p8 q7 s4 d* N
GVT will be cancer terminator， Cytokine storm will be cancer preventor* D2 O1 v* ^( s4 d
2011-12-8 12:563 W; D. f) F) f: J/ l
cell fusion results regeneration，reprogramming，neogenesis，atavism； cell division results differentiation，apoptosis，senescense，development;4 }+ t( Z3 f- L9 n
2011-11-27 14:54
) A$ q" g% d7 i8 WCancer is between protozoa and mesozoa， not metazoa...9 ~% m! M" Q* \& E$ e9 S3 S
2011-11-27 00:25
& a7 `* @+ I, O7 s: G1 o# Scancer is neurological disease！ haha，I got it！( Q2 M$ c3 R% X3 |" I
2011-11-22 22:06
5 |8 [, {, F& ^3 n; }. R6 iyou are cancer，fetus is tumor. 佛曰：汝既是癌 癌胚如来
7 K7 @! ~7 ]$ s6 c9 u" c9 ]2011-11-12 11:274 v4 H  m, d4 Y) B0 a* D9 U
cancer is the ecological invasion of hacker...! V. R4 u; Q* S
2011-10-5 10:31
8 U. O; w; H4 `+ ~6 l" FmicroRNA is  negentropy？
4 f6 a: V2 w3 w* A( c2011-9-24 00:48
- M4 u& [* \. b: D3 e1 ^, Fcancer is the social problem
) c5 ]7 w2 O1 Q2011-9-9 23:33' y. p3 h, F0 r) N" c" R! y
Science is the games of nobleman or madman) N) C2 T3 s. B( w7 [$ ~
2011-9-2 15:034 S+ T+ I! D# ?: D; W
cancer resulted from disturbance of biological liquid crystalline state of ECM2 r+ @5 Z9 T5 a4 Z, H
2011-9-1 20:13
- ~9 ]/ d5 t. x4 z, I( Gniche n-dimensions——space, time, momentum and entropy; energy, material and information flows; physical, chemical and biological factors；topological, thermal, and fractal influences...
9 K9 Y& C% O# e2011-8-13 00:37
$ Y* T6 F% b/ s" K3 [Second recession is coming？5 _3 n0 ~* `( w. I, k7 h) Z
2011-8-9 23:586 {2 T  N' s0 ^0 A% P  A
cancer may be from sexual reproduction of somatic cells.
; M3 }8 n0 o# @4 {, @  |2011-8-7 00:16! f8 v+ v* x5 ?$ [6 a
who determine gene？ genetic determinism is fatalism！
: ^; K/ f* ?. @/ W# x2011-7-30 11:26
$ A2 o; R$ @; \+ dniche reprogrammabllity is the key of solving cancer problems.../ d4 E; s2 f! K0 {. F& Y
songtianlong: i can't agree more!!!O(∩_∩)O~ (8-14 20:42)9 s8 e: f! y0 v' W$ q% L3 o4 p1 |
sunsong7: hehe. thanks for interested in this topic, welcome future discussing (8-14 20:54)
3 S, \& I# ]9 G7 R9 N2011-7-24 01:24
6 @- q: j# j5 Scancer results from acquired genetics alterations.: R9 Y6 y1 t3 M: t- J
2011-7-20 21:37
8 i. R! ?' e* B* GCSCs are the low differentiated cancer cells in G03 \: ]- ?$ \0 t2 t' A- q8 D
2011-6-29 16:30
$ M# L5 m! [# i( T; N: d( }3 oiPS future——in vivo direct reprogramming ...
) a" X) L+ W+ Y6 e' Q2011-5-31 15:20
" {: b* @  Y' D$ M. n/ b7 ]niche reprogramming——cell fate will be manipulated by cytoplasm - microenvironment interaction http://www.stemcell8.cn/thread-40755-1-1.html
2 [% ]* X: `, Q4 E) A2011-5-31 01:28! [" B* D! ~9 D$ w, l2 l) x
all the somatic cells of Mammals are totipotent ！. D+ s$ e8 D; |0 P* P' }
2011-5-22 22:22
5 z: `- S- s6 i6 J/ R4 u$ \* y5 jmiRNA——The manipulator of  cell fate！
' R1 H* l/ Q0 c& n2 H# q9 E; G4 o( |2011-5-20 20:219 j7 k! d; M! b! z" w- i
《Cell Stem Cell》means “cell is stem cell”   活细胞就是干细胞？
, ^/ g* e4 l6 g* A2011-5-17 12:38
+ n3 \- F' x# F' Ncancer —— good nuclear in bad cytoplasm！RNAs are cytoplasmic determinants determine  cytoplasm determine cell fate！ division is differentiation is cancerous is life ！
/ G* ^) ~) x9 u  R2011-5-11 12:31
( i6 N6 Y: G3 a, Vcancer results from cell dedifferentiation...
0 F, i4 x4 [2 e9 F# g2011-4-28 18:07; |# t& n, J1 @& {4 q
differentiation——asymmetric cell division ！
7 h* D8 G8 ]* y4 `2011-4-28 18:04
& R8 W4 J% a  R5 L2 Z, xcancer origins from the regenerative cells！) d0 M$ l$ d' o2 p8 w
2011-4-28 17:52+ |- A3 G! O- {7 X' N+ C
Proliferation is differentiation potentiality！- ^6 v0 u3 \' P" t
2011-4-28 17:498 c% r5 A. n: R$ y
iPS——the key of Pandora box！  D: r' @- C0 |- D! J
2011-4-27 22:360 K* z* S  z4 h4 q9 I3 d0 @
Aristotle— "The whole is greater than the sum of its parts.". z! Y" y1 S0 x2 ?
2011-4-27 00:204 A+ C/ q+ b" {+ C" m! E( }6 N" {
cancer——atavistic cells5 k3 X7 m: E( K; L" F2 p6 T' A
2011-4-20 00:20+ y3 f& W* z3 R
cancer——cellular atavism！) C( |: k% D) S& x6 ?
2011-4-20 00:18
  |7 u) G* i7 x% H1 hcancer——evolutionary ancestors of mammals.
) ~7 }& R# f  N/ ~; X2011-4-20 00:09, Q/ V$ H# e8 n' M" D: Z0 b" K! D
肿瘤是细胞自组织缺陷的产物 
; V+ Q  ^- i  S* j3 b, m2011-4-17 01:41
6 J' g5 ?9 X- P) e$ Wcancer——Metazoa 1.08 c( w, v+ `6 X
2011-4-17 01:00
6 f1 [  K2 j4 X3 K& yUS——the Axis of Evil！5 a% C' q9 a) b# C
2011-4-4 01:196 ]2 x0 P! v! L2 {3 }* B8 E2 W
美国是世界的邪恶轴心！
/ P- W/ _  M; G( Z. s* [. ]: psunsong7: 沁园春.血               ---作者：萨达姆   日 本 风 光, 千 里 地 震, 万 里 海 啸。 望 仙 台 内 外, 废 墟 莽 莽； 东 京 上 下， 顿 时 逃 逃。 核 站 爆 炸， 世 界 惊 涛， 地 震 海 啸 试 比 高 ... (3-22 21:25)
. F9 v' K. J1 Y9 o2011-3-22 19:06
5 X) G  P9 H8 ]teratoma is derived from endogenous iPS！
% z, J3 j" c! g* C; h2011-3-15 21:44& j/ ]0 V4 L7 j& i; _3 `. V9 O
ips is a luxury gambol on  
9 q( l6 p! f) v" i1 w' V/ ]: s2011-3-3 14:50
: [( C+ y3 }- ^5 fcancer is intermediate of species evolution& m/ p: G% G& Z$ K0 x5 L
2011-2-12 12:29
3 u7 l) M- z! wstem cell now is on the eve of coming medical revolution
  [' ?9 W, m. O2 _( H' `2011-2-12 11:20: t4 D$ g& b1 e
Inflamation is the reprogramming process of somatic cell in vivo！
9 u, M# {( {3 C2 S$ I; T2011-1-31 14:49
) G6 i9 G6 g& x+ c0 e. Sso-called medicine is niche regulator！
0 S2 j" l! [8 J% O5 c2011-1-23 21:45
8 Z3 Z5 R. n  h6 g% }. Dendogenous iPS is the cancer initiating cell！
5 X+ W* B! v: T' Y+ n& m- r2011-1-17 16:47! R7 X. Z6 ?/ u* v! S- [8 _/ V
cancer is unicellular organisms！
. q; `6 K' c. N& C3 S1 R2011-1-9 22:04
% U% k- U5 k3 r, bPandorabox Has Been Opened* z5 X( A+ h% |+ X& I) z
2011-1-7 23:248 I$ C6 M* m- f2 d' y: z
iPS is the Emperor's New Suit ! 5 ^- g! P  x- ]* ~$ d; E% c  x
2011-1-5 23:500 Y0 e6 Q  @1 Z5 `  l
cell-free is the final solution of stem cell therapy
$ h, l' [: V2 p* t- g2011-1-5 21:46: O3 q2 S2 B: r; h
niche is telling the story of stem cell...
$ q! |5 P* ^  z, u3 p) e2010-12-29 17:32
% }  c3 y) @: D" W$ i) G+ Bcancer results from reprogramming of somatic cells/ d/ M) u1 D# n& k5 C7 }6 p
2010-12-25 18:56
% x5 R& W6 z: Q! f* Tcancer——good cells in bad niche！4 Q, M! F# s( U+ z5 ]* z
2010-12-25 16:02; T4 S5 Q8 p* s) ~! {
cancer无罪——制造产生罪犯的土壤才是真正的犯罪！
! O. h* k( _1 N% Ederon: 灰常同意，有相关文献么？ (12-19 09:41)
+ u5 \5 t2 ?4 Q  n: @sunsong7: 呵呵，请来参加讨论——癌细胞的发生可能是一种“返祖”现象？ http://www.stemcell8.cn/thread-32073-1-1.html (12-19 11:33): C' {* m' q: p" _/ }3 L9 x
sunsong7: 问题讨论 http://www.stemcell8.cn/forum-re ... 709-pid-246202.html (12-19 13:29)* h- i  B$ i7 @! P0 j
2010-12-18 15:54
5 x3 Y9 c+ N0 D7 u8 q$ H子曰：上善若水 大成若缺——干细胞治疗的终极解决方案将是不移植外源干细胞！
' R7 R. K/ t' D: |: x3 D  {. F  E: T2010-12-15 15:073 J7 f- d7 F: `2 n# W
老狼的记忆——大洪水
9 J4 e, S; b7 w3 n: P2010-12-13 23:25
% B* Q7 E( w! ocan cancer randomly differentiate into norml cell in vivo  
# ]8 r8 M/ J& \+ m3 s; f! Y2010-12-13 22:33
1 ?$ b; \1 Y& gomnis cellula e cellula4 w+ p1 @* v/ B% j
2010-12-12 09:28
# v1 p; U7 N, {2 p4 eStem Cell ——The Origin of Disease. k) U4 J  d6 n2 P
2010-12-12 09:27
4 x9 v0 w1 z- |7 w

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