老狼的个人空间记录

sunsong7

"genetic mutation" should be exactly as "gene self-editing"  D' O- ?& \4 Y; V% _: L4 L" x$ {
2017-12-1 13:17( M8 F  W2 ~: z/ u2 q
Bioreactor in vivo would be the terminator of illness.0 o6 _: s  W- B6 C2 v$ G
2017-11-20 23:09
/ y" q1 Z/ k! y7 p- c, O/ frenew tech：剔除衰老（病变）细胞占位可以恢复青春。8 U; J6 P9 W9 K# V" W8 v' {
2017-10-23 12:505 D" o( B/ Q, |2 J8 Q7 o+ v+ e. u6 E
魔不疯，鬼不魅； 道非盗，仙非妖；神无形，兽无极。
7 Z* s8 \! D% I6 F, F/ r2017-9-30 10:58* ^8 `$ ?- q, f5 }$ e- ~+ O% C
Life 3.0——from decoding and coding to reading and writing, a6 _3 ^7 H5 `9 G
2017-9-21 22:32
* v0 b5 V& Q. @1 r; A理论创新：亮明立场——先颠覆，再完善
% e1 N5 ]7 {, M9 H2017-2-7 00:077 s; r- e" J, @, j/ Z* ~0 \9 {
干细胞第二定律：与细胞外基质共同构成多潜能；1 n9 [& n% @; L+ ?
2017-1-3 11:14: D% E8 y0 O  @" X: E4 L$ J, [
干细胞第一定律：全生命周期保持增殖分化能力；
- p; R) y! H( g- Q6 u2017-1-3 11:13
  \' H8 _7 ~2 k& ^8 uNgAgo——Never give A guideline operated！
1 p  f( u9 L+ F- Z9 i) z2016-12-1 10:093 s) W  M/ l! z% y8 r; v! _
表观遗传—— 一切皆可改变  一切皆有可能; K4 D4 ?* V& H, L7 t. l& y! N
2016-8-17 23:37( r2 ^& }/ C7 Z) h0 [* M
子曰：吸血鬼疗法——养儿防病 养孙防老
0 F. U  s9 \- j2016-5-23 12:05. O7 G7 w; d% ~) n- R. Q% h  r
NgAgo——Debug tool kit for mammal cells
( R0 K3 E0 b. ?2016-5-9 13:09
- |6 O: Q/ \" T2 M: i公理之外 皆需证明； 科学命题 皆可证伪。
+ i# A; _3 f2 e7 n: \8 P; ]/ i0 g* j2016-1-2 00:204 m5 n& U9 p! d8 t
低氧——破坏线粒体功能、诱发炎症、导致基因突变
* T! `  ~9 S- }6 b, a. |, H7 Q* D2015-12-16 20:19
5 v6 R) e8 F+ u癌症——炎症部位组织再生过程中细胞去分化失控形成的幼稚化新生物。
% Q  M- J. a  o, a- |5 Y) R3 D5 |hcoohboy: 一个有趣的假设~但是没有炎症就一定没有癌症吗？ (12-18 16:16)( w* v; S3 i! v6 j) q2 K2 ]
sunsong7: 炎症与癌症同在，Hanahan D, Weinberg R A. Hallmarks of cancer: the next generation[J]. cell, 2011, 144(5): 646-674. (12-19 19:45)# a0 l) m( a; e. e% h4 u
hcoohboy: 3ks~ (12-24 16:45)
" a0 `: q3 |# w$ d) `% F2015-11-18 15:54
! v9 t- e- L1 s抽象世界与客观世界的真理判别标准是不同的： 在虚拟数学世界里，逻辑是一切命题的唯一审判标准； 在客观物质世界里，证伪是一切定律的最终审判依据。0 ~4 m( G' m* m# F7 n
2015-5-20 14:13
' F7 l1 p% K$ X4 \- u- a# }  R* { 传统生物学将死：进化论=自然神论   基因轮=宿命论   细胞论=活力论翻版。    现代生物学曙光乍现：系统生物学=数学 结构生物学=物理学 合成生物学=工程学4 P# G9 `) I' B. ~, V
helong: 系统生物学是把细胞、基因、进化、物理学、信息学（数学）、工程学等都打包起来的所谓新学科，目前只做到了简单组合，还没有达到系统集成阶段。合成学更多偏向于化学。 (4-21 19:28)9 r  |* K, K9 p5 U/ w# L# K
sunsong7: 方向对头，努力总会有结果的 (4-21 20:05)2 v7 x( ~, l; ]1 e- L
2015-4-21 16:46
/ m& ~- w7 M0 ~" esearch and research is just disassembling the creature.
/ C9 F# h% _( c5 k1 N; M2015-4-7 17:016 w! s$ k  ^3 y* `1 k# f4 D  g, r
selection is  the act of intelligence) l" H8 o4 A% B1 V1 b2 Y% x7 I
2015-4-7 13:49
6 C% {4 |/ k# m+ [4 ~Genome fusion create neoplasm. K; C0 S' E$ n/ S* d8 T
2015-1-20 13:10
5 {7 L. B% e* j, z4 OSTAP——Stupid Trick  Against Professional ( t- {0 R" ^8 s
2015-1-1 19:29! T8 T( @$ m9 T0 e& `
information=structure=negentropy
3 f7 a) i9 P$ n3 X" H0 a5 T2014-7-22 17:36: S1 B. H' p  {0 a3 D3 _/ o* b
Natural mutation does not result in new functional genes 5 A9 N! O! K/ J0 y
2014-7-3 14:06
$ N2 v1 P% n; W  \life is wisdom creation instead of natural evolution# F6 z& H) v, D. g* H
2014-3-27 09:337 ^. X- f: }! ~0 F( @' C
let us explore the source code of life !
! _8 }8 ?  l+ _5 H1 J# ]4 P2014-3-11 13:117 l8 x0 q4 d! d; w4 I( n! ^% W" \* |
bio-manufacturing——processing，machining，casting，printing，3D prototyping，duplicating，cloning，life replicating.8 w& x0 E; {+ _  }3 [' A9 U9 S, a
2013-10-7 23:06( ^0 _# N% t# a$ r5 z  }
induced abortion would give the key for curing cancer 
  A; j( X" u$ ^) l! b! r( t, E! d2013-10-2 23:33
4 o- t  s& K% e1 a! S“key breakthrough” in molecular biology are entertainments
* e( F6 B" v% Z; s# K2013-6-16 11:505 m5 ]+ j' R* _; ?# `
Rules Of Living：trial-and-error exploring，survival takes the legitimacy% P8 s8 b2 j' @; E" z8 H* V
2013-6-16 11:27. v- ~9 n+ j4 d9 ]1 y
Life is a set of debuging programs
, V: a' }0 e, }5 ^2013-6-15 18:40
& P) ?/ }4 M+ H5 z- _current biology is closed，destined and agnostic，it is  the only contribution is to kill cells
7 v0 K' y3 ]/ \' g2 Q2013-5-2 08:54* x/ o' L% l0 D, L  \9 C
information，energy and construction are the new base stone of biology，instead of evolution，gene and  cell  tales
* F0 V, @2 B! u# x2013-5-2 00:51
! G0 k; |% [  _9 J8 tvirus is the messager of  the universal life network) l5 \7 P/ x5 n+ L  k/ `
2013-4-18 14:331 L% {( K) C' F8 X7 x- U) G- I
Genetic information doesn't improve cancer risk prediction
4 Z# c& [' a( d+ \% I9 `# z( j2013-4-1 09:20  O' o- g: w9 a( K8 {4 F1 I) R
There is no early diagnosis of cancer，but early prevention of it; r* v& ]  d8 t) C
2013-3-27 09:178 A9 E  D( ^+ Y2 ^( _
hypoxia maintains stemness or carcinogenicity, h1 D. h& B+ B( J8 U' h/ p! `( Z
2013-1-2 05:21
# Z1 }0 x, _8 {* r( Ecancer is the living fossil records on origin and evolution of human being
3 A3 q* {4 T: A9 o2012-12-9 23:31  J( p6 _+ _9 J4 d
information island results cancer
$ \: B9 d! g' t2012-12-9 05:239 I" P' f7 v3 s5 d4 y6 e
life is digital game
! a& b* o. K9 ]2 I' d5 N2012-11-10 00:171 c6 o: h( D2 V& }$ w' G/ ]
cancer ——severe abstinence reaction of cells to niche addiction
) t& h% g' k; u& J9 u3 R2012-9-28 12:110 b4 q/ X- \+ C! G
未来生物学终将回归物理(熵)及数学(分形)的美感/ c1 p$ g+ y+ s2 D, i2 f
biomater: 熵理论适用于任务物质。。。。也适合于生命 (9-26 09:28)
! m+ I+ R( m3 r2012-9-25 21:22
# l. t" ]' U3 I$ U" n  J! _membrane holds the key to life) ]) X) Y, i' h. @: Y- h
2012-8-19 20:24% S$ s3 b- u* I
Cancer is the default state of cells
! P+ Y1 m: p: z8 g% g2 z* O' N: |2012-6-26 22:179 q3 y. M& A: M( U! i# N7 \$ l
mainstream cancer theories could be overthrown！0 W# q4 ^+ \6 I9 h6 X
2012-6-25 15:43% w0 K* ]5 z, p6 |' E+ h
carcinogenesis has nothing to do with the gene mutations but is  the result of niche reprogramming...
4 a+ ]3 [* G/ \2012-6-7 09:36# N; e/ i; [- ?) v
every living organism connected with the water， one cell one world
! l: Q$ n1 b7 b" ?0 w% x% I! d2012-4-19 22:06
0 F. w1 h! c$ M6 V8 l2 o% Zchemical structure of cancer cell determines it's biological function...
2 ~: N" o! B' L+ j2 T2012-4-7 17:56# _" i. k5 d+ ?
Mann tracht und Gott lacht
9 p+ K: }  @$ x$ ]2 a; W2012-3-24 21:34
0 @3 g6 l' M* V8 B; P, B4 {# ADarwinism or genetic determinism is a fairy tale！
# P% f. ^! D) r9 a& N7 E! A1 v5 F2012-3-13 15:18/ i. K- J7 l( }  p
niche isolation is essential for cancer speciation
; J! X$ J$ o% k' o- K9 r- }2012-3-12 12:071 F2 t7 a. i3 c- g1 ?( T* `
Hybridization Creates New Species，Mutation results species extinction
2 |5 e9 F- L! C7 E( ]$ h% v2012-3-11 18:21
# ?& M6 r8 ?' E% k1 oROCK may join the niche reprogramming...- k3 i( S- C7 J( R; L
yuhaoze: 这是篇文献吗？ (3-9 10:41)7 u  Z! e! e& @) G
sunsong7: http://www.stemcell8.cn/home-space-uid-6268-do-blog-id-1211.html 突破：病人体细胞及肿瘤细胞长期体外培养（附原文） http://www.stemcell8.cn/thread-51419-1-1.html (3-9 10:46)
' n1 ^: H' T- n# dyuhaoze: 啊， 我看过这篇，还顶了呢，谢谢哈 (3-9 14:37)5 z! m8 J, j) p/ X3 A" \8 ^
2012-1-19 10:52
% A  H+ f4 C' @5 h0 Loncogenes are pseudoscience
+ w- ~+ q6 R6 e4 a# G! O7 [2011-12-29 13:55
9 v9 c5 r8 Z6 |( t7 E9 Egene mutation leads to variation or extinction, not new species4 p8 k; g; O5 q2 T
2011-12-29 13:28
" u% Z* u2 ^9 M; ^) ^. |0 ioncogenesis is non-Darwinian event
4 P1 U4 I* K, n3 ^7 c4 ^9 W/ F2011-12-28 22:560 W6 N' g! p& ?" N2 u% z5 s, {2 l
disorganization activate neurogenesis activate oncogenesis   
- k4 s% m! @8 D  ?3 n  E/ s2011-12-22 23:38  @# c" v  |; v
MSC is cell feeder，tissue scaffold，immune firewall and biological glue
* p  o! t5 z( `& y2 C& U2 Q" d2011-12-19 19:46/ \. m/ ^2 A! q" F5 h3 Y2 M! n
cancer is Noah's Ark（species carrier and life explorer）: z4 m  y0 _( ]( D
2011-12-10 09:46* P, L! r0 a1 Q& Q( F4 t
cell fusion create new species, gene mutation induce variation
& J7 F6 k, n4 D8 u2 p5 \2011-12-10 09:36
( @5 V; K" |1 D% ]. [& G) ]GVT will be cancer terminator， Cytokine storm will be cancer preventor! A; i$ |' W! \% y; _: x8 L# Y
2011-12-8 12:562 |& X7 `" j6 [- D
cell fusion results regeneration，reprogramming，neogenesis，atavism； cell division results differentiation，apoptosis，senescense，development;
1 g% q  b# O" H. k2011-11-27 14:54
( `+ I) I4 b) X  D/ M0 T6 t8 F9 VCancer is between protozoa and mesozoa， not metazoa...3 o) {' ]) n/ ]1 }# B9 w$ G4 _/ N/ c
2011-11-27 00:25+ Q7 ~7 M4 f, |- Q# W9 k! i
cancer is neurological disease！ haha，I got it！
8 z+ I: v" y+ r5 a2011-11-22 22:06
" x3 d4 E1 }5 o! R* [you are cancer，fetus is tumor. 佛曰：汝既是癌 癌胚如来
9 P; T% Z/ T, k2011-11-12 11:27
1 B7 o& @3 [" m; }* Gcancer is the ecological invasion of hacker...
9 V2 S( \, W( M* j2011-10-5 10:31
2 ?0 o- j0 m4 G3 R, n1 NmicroRNA is  negentropy？2 O/ P7 N% q* O! E4 ~1 M
2011-9-24 00:48% h7 ~! B' x4 L, G2 {) F- \
cancer is the social problem
3 ?5 N: ?: g  ?  B9 a& W' U) R, r8 j( E2011-9-9 23:33
8 ~, ]2 t& w2 }+ q, ]( z( bScience is the games of nobleman or madman  M% Y' w" ]5 C# v. n: R
2011-9-2 15:03
" ?& O% M5 p3 @- {3 u, ^/ e* t9 icancer resulted from disturbance of biological liquid crystalline state of ECM8 ?% l& R8 B" \; q, f" H; Z5 U" P
2011-9-1 20:13& Z5 ~/ y3 J- j: }6 ~- h
niche n-dimensions——space, time, momentum and entropy; energy, material and information flows; physical, chemical and biological factors；topological, thermal, and fractal influences...
0 p- e1 H% M  P6 L2 h0 R2011-8-13 00:37$ ]1 ~1 P  h: o
Second recession is coming？0 c1 P! A; o) c7 N- V- e
2011-8-9 23:58% C, ]2 \. y  n) O
cancer may be from sexual reproduction of somatic cells.& l; {; S/ p# m+ }9 m& K; P
2011-8-7 00:16
+ L1 p. g; v) ]0 r! _who determine gene？ genetic determinism is fatalism！
. x0 W% I6 B% V2 Q" K2011-7-30 11:26/ f# y9 c. [  u- H% [
niche reprogrammabllity is the key of solving cancer problems...
; Z+ x: B1 p) `, X& Asongtianlong: i can't agree more!!!O(∩_∩)O~ (8-14 20:42)- R/ ?+ Z- y6 b0 |
sunsong7: hehe. thanks for interested in this topic, welcome future discussing (8-14 20:54)
- j; E5 o* Y5 }2011-7-24 01:24
/ V5 X" a* Q! n' Y9 U' Gcancer results from acquired genetics alterations.
% ]; @* Y- t& y, h6 k- T4 g2011-7-20 21:37
; F! j2 ~0 i* @9 @+ m* ?# nCSCs are the low differentiated cancer cells in G0! f% j* _$ H/ A
2011-6-29 16:30
. w! [, s/ c5 {: EiPS future——in vivo direct reprogramming ...% }  Z& n6 |% V! i
2011-5-31 15:20* E; s: h" [6 r7 a5 {$ |$ e
niche reprogramming——cell fate will be manipulated by cytoplasm - microenvironment interaction http://www.stemcell8.cn/thread-40755-1-1.html& z' W* T/ c, O
2011-5-31 01:281 Y/ H9 m/ f, R
all the somatic cells of Mammals are totipotent ！
  l+ X2 g, Y% t$ \( t: M% E) _$ ^2011-5-22 22:22
4 D1 b% y# z3 B, B4 O* AmiRNA——The manipulator of  cell fate！
) [! G% n0 }( ~3 N2011-5-20 20:21
+ e; f+ [( ~8 ]2 u6 u7 Y《Cell Stem Cell》means “cell is stem cell”   活细胞就是干细胞？9 R+ P) @5 h9 G, l+ @* _3 Q
2011-5-17 12:38+ g9 k, E5 H, r4 }, F" {
cancer —— good nuclear in bad cytoplasm！RNAs are cytoplasmic determinants determine  cytoplasm determine cell fate！ division is differentiation is cancerous is life ！( M/ |0 b/ M" {0 g& p) D$ S/ W
2011-5-11 12:31
, V. g6 a& N! v/ w, g3 ]; Ucancer results from cell dedifferentiation...% q! p% w& c" {" M8 R+ G
2011-4-28 18:07
( E! b# W( X8 [differentiation——asymmetric cell division ！
/ k6 r6 O4 t. F+ s2011-4-28 18:047 W' z. W0 x, t7 Y3 V
cancer origins from the regenerative cells！- N( }2 }4 x5 O* V5 N0 A4 b
2011-4-28 17:52+ }) a' Z/ N8 R
Proliferation is differentiation potentiality！6 W' O$ k9 k5 C0 P! K: Y: C
2011-4-28 17:49: A5 ]( c& L: G4 F
iPS——the key of Pandora box！
7 S; \& ^7 p8 l; Z) M# ?2011-4-27 22:369 C8 s: J% x. q( l  y8 s
Aristotle— "The whole is greater than the sum of its parts."
+ x- r; D9 _. h+ K( G  R( B2011-4-27 00:20
! d# |% @& r  A0 ocancer——atavistic cells
% O7 S; r0 B# u  |* S/ U7 Z7 d; W2011-4-20 00:20, N+ c1 O0 a8 K! s8 `
cancer——cellular atavism！
. \! S" |* B9 j) x+ S; C/ d2011-4-20 00:18! G) Y+ k% C8 B+ y4 T  C3 w
cancer——evolutionary ancestors of mammals.
+ W7 s% ^7 p& Z' U* P" |/ X2011-4-20 00:092 ?. o$ L% ?. D' b2 k7 R
肿瘤是细胞自组织缺陷的产物 % h0 A6 e! ^6 W: m* v; b2 l% I  R
2011-4-17 01:41
9 Q6 B2 L; v; u9 H/ I% e* a4 [cancer——Metazoa 1.0  L3 G( B; t1 q& W! w
2011-4-17 01:00$ \: f  f2 d$ x6 ?
US——the Axis of Evil！$ }* d% r( v, D1 e8 l. i
2011-4-4 01:19
% H9 l* Z- V8 \美国是世界的邪恶轴心！/ q, }, j& a8 s( k
sunsong7: 沁园春.血               ---作者：萨达姆   日 本 风 光, 千 里 地 震, 万 里 海 啸。 望 仙 台 内 外, 废 墟 莽 莽； 东 京 上 下， 顿 时 逃 逃。 核 站 爆 炸， 世 界 惊 涛， 地 震 海 啸 试 比 高 ... (3-22 21:25)0 @) }2 u. r/ D- q2 T0 F9 T& F5 d
2011-3-22 19:06# w( q9 u' t& {$ e1 L: t! d
teratoma is derived from endogenous iPS！- {) B+ a+ L4 w# s, R
2011-3-15 21:44' P% B" z6 @6 F3 O  W
ips is a luxury gambol on  3 }: k. a! f3 `% W- ~- C  X
2011-3-3 14:50  e& J8 W  m* `2 B) s
cancer is intermediate of species evolution
$ y; ]7 D* d8 w2011-2-12 12:29
  r) p, s2 l3 q: T2 M( U( \stem cell now is on the eve of coming medical revolution# X/ H6 n* s/ {. Q, A5 J$ d
2011-2-12 11:20
5 B. B0 z) I% H! K6 T  [6 I8 o7 dInflamation is the reprogramming process of somatic cell in vivo！
" G2 c3 ^4 W7 s- A; W) p9 m2011-1-31 14:491 Z! X8 U( X# Y1 [( b" a
so-called medicine is niche regulator！6 B" D2 t, H  ^9 U# T% j4 X
2011-1-23 21:45* B: s- L! V8 s6 d+ A: R
endogenous iPS is the cancer initiating cell！
$ k* |  ?! r2 Q# u- n& L8 y' a2011-1-17 16:47& T" h* Z- V  {3 {3 x# J* K
cancer is unicellular organisms！9 R4 H  @; A* }8 W8 c
2011-1-9 22:04- _) o" w" m% r% ?- K: R9 `/ e9 T
Pandorabox Has Been Opened0 S: p( i0 ]6 X! N. n2 S9 z  v& q2 m
2011-1-7 23:24
6 |) ~; g$ c3 A. O8 m) @iPS is the Emperor's New Suit ! 
1 m- l- ?6 o4 a0 N2011-1-5 23:50* B( E5 B: G6 j
cell-free is the final solution of stem cell therapy6 m4 Z: f' j0 o' g5 T
2011-1-5 21:46
5 m( J6 m# S, J  v! C* G, a, aniche is telling the story of stem cell...1 ^$ |: C- u% v" Z
2010-12-29 17:32
$ k# O# N( Y' n! H9 ecancer results from reprogramming of somatic cells# K4 z& U: L3 K" I; Q! Q- P8 V
2010-12-25 18:566 U8 C1 I$ @1 M2 ?2 B# \
cancer——good cells in bad niche！
$ a" A& `. Y. r' Z. J2010-12-25 16:02
4 r6 ^6 r4 s: e- w8 \1 _+ n- ycancer无罪——制造产生罪犯的土壤才是真正的犯罪！0 u  ~/ t: j& Q' h
deron: 灰常同意，有相关文献么？ (12-19 09:41)
, v) H6 P# K( Gsunsong7: 呵呵，请来参加讨论——癌细胞的发生可能是一种“返祖”现象？ http://www.stemcell8.cn/thread-32073-1-1.html (12-19 11:33)6 r$ h9 c3 W4 e+ I; Z; w( c' {
sunsong7: 问题讨论 http://www.stemcell8.cn/forum-re ... 709-pid-246202.html (12-19 13:29)
2 h) B6 f' Y8 \" V$ ~) w2010-12-18 15:54* v+ U0 |& @7 ~* Y
子曰：上善若水 大成若缺——干细胞治疗的终极解决方案将是不移植外源干细胞！
- c" B# a9 n& I& c7 X' |4 h% Z- V: N2010-12-15 15:07
# t2 y% ?2 P; `1 G) L- i2 x老狼的记忆——大洪水, G8 j$ V! |& @9 B; D0 Q. l' o
2010-12-13 23:25+ g, Z  W+ T2 h/ o/ S! ~' {
can cancer randomly differentiate into norml cell in vivo  
* J" u& `7 {) ~% V" A! |1 ?3 I2010-12-13 22:33
. ^% g- C! R  y+ i) g+ _omnis cellula e cellula
1 p6 g7 {, k. Q& ^2010-12-12 09:28
: P0 J5 \4 T4 ^/ z3 N  z! cStem Cell ——The Origin of Disease
' q7 b7 S: H7 w: D0 N2010-12-12 09:27
; m' y8 m5 i; T1 q: E: m

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