老狼的个人空间记录

sunsong7

"genetic mutation" should be exactly as "gene self-editing"
" J9 @/ q1 u1 |; A5 T) \2017-12-1 13:17/ E) d1 r1 T8 x2 O
Bioreactor in vivo would be the terminator of illness.
( e/ Z  {. a2 ~2 p2017-11-20 23:09
) p9 Z$ O4 t: h& z* Orenew tech：剔除衰老（病变）细胞占位可以恢复青春。
. N) M0 @1 b+ k- M$ t! t2017-10-23 12:50
2 x: B% N2 G) v  V* K! v* r* Z8 q, p魔不疯，鬼不魅； 道非盗，仙非妖；神无形，兽无极。: z; q( G# ]  L
2017-9-30 10:58' I" z0 J& s" f5 ]5 u" @
Life 3.0——from decoding and coding to reading and writing( D9 u. H& P) g' B
2017-9-21 22:32
* B. s% E% h  }; j8 ~, b. {理论创新：亮明立场——先颠覆，再完善
& Q2 `' w4 \( Q+ x  O2017-2-7 00:07
+ A1 g9 Q2 n% d4 ]' p/ C+ d9 z干细胞第二定律：与细胞外基质共同构成多潜能；
5 L" c5 U  f7 n+ L/ d2017-1-3 11:14
2 i: g5 k; u9 h干细胞第一定律：全生命周期保持增殖分化能力；
) k+ A$ m- z+ b% m) H4 C: q; {2017-1-3 11:134 A- R: M8 Z& G8 }3 G4 I. n
NgAgo——Never give A guideline operated！
, z" I; @4 `! r1 |6 a' ?2016-12-1 10:09: j# i- s; {" w& @/ s
表观遗传—— 一切皆可改变  一切皆有可能8 X* [) }. ~* F
2016-8-17 23:37
; Z+ n% A7 h  h4 f' G子曰：吸血鬼疗法——养儿防病 养孙防老
5 V) [8 b$ `4 f$ Q7 X2016-5-23 12:05! {2 d4 g) ?% b0 g+ `! ?% z
NgAgo——Debug tool kit for mammal cells
6 X' e4 t3 W0 D* Z& ]2016-5-9 13:09
0 U" }- T% G! K公理之外 皆需证明； 科学命题 皆可证伪。
: ?+ L$ i- ^1 y! Y; H2016-1-2 00:20
& }0 L% i. j* x- |' c3 G4 \低氧——破坏线粒体功能、诱发炎症、导致基因突变& d5 i! w0 n$ x$ D% j3 o5 {
2015-12-16 20:19
4 I6 @8 T" C4 p" [癌症——炎症部位组织再生过程中细胞去分化失控形成的幼稚化新生物。7 G5 o; P! C' Y6 _1 C+ |
hcoohboy: 一个有趣的假设~但是没有炎症就一定没有癌症吗？ (12-18 16:16)
& w/ U0 d- a; w7 A; n2 Esunsong7: 炎症与癌症同在，Hanahan D, Weinberg R A. Hallmarks of cancer: the next generation[J]. cell, 2011, 144(5): 646-674. (12-19 19:45)
: P+ ?# [0 e3 Y1 p7 `+ Lhcoohboy: 3ks~ (12-24 16:45)  x1 c& P6 V% F
2015-11-18 15:547 D5 c/ ^7 E: M1 m7 Y- c
抽象世界与客观世界的真理判别标准是不同的： 在虚拟数学世界里，逻辑是一切命题的唯一审判标准； 在客观物质世界里，证伪是一切定律的最终审判依据。8 Y4 a) p* Z* j+ M0 C2 m' H6 h
2015-5-20 14:13! O, G7 g* u; f1 Y1 A
传统生物学将死：进化论=自然神论   基因轮=宿命论   细胞论=活力论翻版。    现代生物学曙光乍现：系统生物学=数学 结构生物学=物理学 合成生物学=工程学
6 @8 X# ~" W! a4 khelong: 系统生物学是把细胞、基因、进化、物理学、信息学（数学）、工程学等都打包起来的所谓新学科，目前只做到了简单组合，还没有达到系统集成阶段。合成学更多偏向于化学。 (4-21 19:28)
. r# ^. @. e- b2 usunsong7: 方向对头，努力总会有结果的 (4-21 20:05)
, t# u0 D+ V) h7 E; o4 Q" s2015-4-21 16:46) j1 {, K8 D" S6 n3 K/ Z
search and research is just disassembling the creature.
$ g' [$ a! _6 P4 g/ N7 u4 p' m: b2015-4-7 17:016 U4 {) t, ]* L. z
selection is  the act of intelligence4 T+ m) i: M1 |% Y8 T# _
2015-4-7 13:49
3 [1 D5 z6 e! }! \9 sGenome fusion create neoplasm# D/ m+ q; F( D2 L- n3 a
2015-1-20 13:10
7 ]/ F7 @  ~( j: I. L& xSTAP——Stupid Trick  Against Professional , N; C1 A- T8 z: p3 A  z
2015-1-1 19:29
: {: H  f' P: U1 Dinformation=structure=negentropy
/ ^" [7 F) E% ~8 u, e! _- a2014-7-22 17:36
& T  S! l, ?. ]# S, d* LNatural mutation does not result in new functional genes 4 Y* ]6 R  z, @; Z0 @
2014-7-3 14:06
" p5 y  A! A' Jlife is wisdom creation instead of natural evolution7 \$ Y3 E( x/ A) R3 F( A$ K: L3 n
2014-3-27 09:337 t$ l3 q% ]7 o1 a% k" P
let us explore the source code of life !$ n/ y7 ]/ V7 u( E6 x+ D
2014-3-11 13:11
9 r8 X6 B# k3 n9 c$ ~bio-manufacturing——processing，machining，casting，printing，3D prototyping，duplicating，cloning，life replicating.
; _$ l. ]% A6 t( i2013-10-7 23:06
6 D9 k1 r) {# y; l  n9 V4 @induced abortion would give the key for curing cancer 0 ^* [+ D8 ?( i4 {+ |: t
2013-10-2 23:33+ b) g8 L& |0 R4 B0 Z
“key breakthrough” in molecular biology are entertainments
, U' X$ O. J, j2013-6-16 11:50
! ?7 G9 z0 z8 U$ P( ^Rules Of Living：trial-and-error exploring，survival takes the legitimacy5 j* F6 c1 o5 [/ [5 ]% y
2013-6-16 11:27
( v  k. k  N8 D! F7 f2 [- iLife is a set of debuging programs, r3 Y8 j. u7 O
2013-6-15 18:40# \% ^- K4 J0 }) {  F: f6 Q
current biology is closed，destined and agnostic，it is  the only contribution is to kill cells
  D- F3 f5 r- I; H8 j* t  C2013-5-2 08:54
* l& S0 g# x+ a9 ~! l' [* i1 dinformation，energy and construction are the new base stone of biology，instead of evolution，gene and  cell  tales
/ f* I/ v3 g1 f4 p2013-5-2 00:516 E$ {2 j6 t! q' L9 |
virus is the messager of  the universal life network' h. `# m5 X. v# v! J, Z6 P+ x
2013-4-18 14:33
& K: o2 l* {1 I0 s' s4 k. UGenetic information doesn't improve cancer risk prediction
: N. [/ f! A  {% f$ \. W2013-4-1 09:20: P; Z' m6 D/ I! M" Q
There is no early diagnosis of cancer，but early prevention of it
) @. K4 T  C% g* V# g; y2013-3-27 09:17. X/ O) D4 o- f0 [. L+ b
hypoxia maintains stemness or carcinogenicity
2 Q3 P# x3 S1 ^# v2013-1-2 05:21, U; g$ ]5 X7 `, y9 M& F
cancer is the living fossil records on origin and evolution of human being
6 `# [' s+ O" {$ D+ t2012-12-9 23:31
7 V! O- X. W. C# Binformation island results cancer
4 ?8 u% W: v) s8 `2012-12-9 05:23. m3 ]+ W# c! V8 w+ G7 `# c7 d
life is digital game
. x& ]+ h4 |0 C! v2012-11-10 00:17- }2 O# U. W. i7 E
cancer ——severe abstinence reaction of cells to niche addiction( T* l% c' B' \2 F9 d
2012-9-28 12:11
8 K/ D3 d& G) z* k% g未来生物学终将回归物理(熵)及数学(分形)的美感
  p4 M9 x, x% Z- U0 Mbiomater: 熵理论适用于任务物质。。。。也适合于生命 (9-26 09:28)
6 ?) V" v, g2 b4 }6 g  |; j2012-9-25 21:22
* @9 D$ Q- G5 I1 j* i5 G3 Emembrane holds the key to life: |4 \$ B/ N. o, ]: [4 }% Y
2012-8-19 20:249 g0 P* a& @. N: U* ?4 s" h: a
Cancer is the default state of cells
1 r& c. d: c3 d- B# c2012-6-26 22:17
- T( g2 X! `) `* I2 Lmainstream cancer theories could be overthrown！
# M$ c* E2 v6 `, X- j% z. c" l2 k2012-6-25 15:43
9 c- q7 ?7 R8 zcarcinogenesis has nothing to do with the gene mutations but is  the result of niche reprogramming..., A( l8 m0 S! U3 j
2012-6-7 09:36
& Y% Q+ R. n' W6 p/ k- yevery living organism connected with the water， one cell one world
- f7 g* l' N; b$ n7 r2012-4-19 22:060 t3 e3 w7 m- @8 W- b$ J# j
chemical structure of cancer cell determines it's biological function...
: T; Z( l. c) o, q, ~( }3 |2012-4-7 17:56
' J1 x; `5 `% O4 W; aMann tracht und Gott lacht0 V3 e5 z; |/ i& g
2012-3-24 21:34
9 b* @% Z. ?6 iDarwinism or genetic determinism is a fairy tale！0 C: o* L2 E3 ?9 T5 a% T
2012-3-13 15:18! ^) g/ _4 `% p$ P5 f( u. C% Y
niche isolation is essential for cancer speciation
- G# E3 q$ V! i9 z9 \& z0 o# d2012-3-12 12:07
& M! s7 O! ^9 A- q5 D8 R* d! \# QHybridization Creates New Species，Mutation results species extinction- Z( R& z5 z* V" H: W0 C
2012-3-11 18:21
1 \4 `! t% s: u9 O5 s/ a. RROCK may join the niche reprogramming...
) [  x) m9 n/ g0 tyuhaoze: 这是篇文献吗？ (3-9 10:41)
# l- q! Y2 y6 W- d: n# qsunsong7: http://www.stemcell8.cn/home-space-uid-6268-do-blog-id-1211.html 突破：病人体细胞及肿瘤细胞长期体外培养（附原文） http://www.stemcell8.cn/thread-51419-1-1.html (3-9 10:46)
2 w! u# s& j1 O0 s1 s0 M3 B, b. Kyuhaoze: 啊， 我看过这篇，还顶了呢，谢谢哈 (3-9 14:37)/ }- C8 ]6 ^0 P, y
2012-1-19 10:52
7 h. J9 B2 l0 c0 v/ h* C0 I- Z0 goncogenes are pseudoscience
7 Z+ `  U0 Y7 g: A3 l  V3 `5 x2011-12-29 13:55
2 u" j, p7 Y+ ~! R3 Pgene mutation leads to variation or extinction, not new species
; g: B6 A5 p/ a% {( T2011-12-29 13:28
) B4 t& k) U( J7 D- B( o2 V# Voncogenesis is non-Darwinian event+ h' J0 _& c/ {
2011-12-28 22:56; N7 h/ i9 V" \- T( t
disorganization activate neurogenesis activate oncogenesis   0 f7 ]  F; e% T( G( T2 Z" p
2011-12-22 23:38
* M1 N, @& u$ N, PMSC is cell feeder，tissue scaffold，immune firewall and biological glue
1 ]# z7 `9 N3 g2011-12-19 19:46
) K8 e- [; z# O9 B/ Icancer is Noah's Ark（species carrier and life explorer）) Q  N* v# n4 F- ?/ s9 J$ ]6 _
2011-12-10 09:46  l5 U! @7 D$ S1 l1 e  ~, V4 w
cell fusion create new species, gene mutation induce variation. x2 Z* T$ ]2 L& R' z! O
2011-12-10 09:361 ~6 @# ?2 U4 n0 ~4 h
GVT will be cancer terminator， Cytokine storm will be cancer preventor- }# M; `* `- Z$ S5 F$ f; e
2011-12-8 12:56
4 p9 o- A1 V* a" H2 tcell fusion results regeneration，reprogramming，neogenesis，atavism； cell division results differentiation，apoptosis，senescense，development;8 F. S0 c$ j, Z' T9 z8 j3 T6 j
2011-11-27 14:54
! `& s. Y) t( YCancer is between protozoa and mesozoa， not metazoa..." N2 U0 S, q. B  r: B7 o1 h3 \
2011-11-27 00:25
3 D, C' j0 g  r7 |# vcancer is neurological disease！ haha，I got it！
- R  Z. w. c7 L6 F2011-11-22 22:06) M, g1 Y3 N' b
you are cancer，fetus is tumor. 佛曰：汝既是癌 癌胚如来5 ]# V# i- t* h( E, T3 C& r) w# w
2011-11-12 11:27
) U' L8 }0 L, g- m' Y8 vcancer is the ecological invasion of hacker...4 N1 s2 R* L9 N
2011-10-5 10:31- Z6 n- z) E  }
microRNA is  negentropy？
# Q% ^4 t' o( `( B3 h8 ^% N( k9 r2011-9-24 00:48/ M; ^4 K9 ?+ [: P  _6 a
cancer is the social problem
: a( R. u5 A: h% n3 v4 g* A2011-9-9 23:339 b# x. ]( T& L' b, d  T
Science is the games of nobleman or madman
; W. p6 @, v% t" q# b' Q2011-9-2 15:03
9 O  G  G) H" l' }cancer resulted from disturbance of biological liquid crystalline state of ECM8 g5 p8 J( c" P0 n/ ]
2011-9-1 20:13; ]" c4 _4 h; n
niche n-dimensions——space, time, momentum and entropy; energy, material and information flows; physical, chemical and biological factors；topological, thermal, and fractal influences...
0 W% m0 V( @: `5 r$ u( P2011-8-13 00:37
% K9 w0 j2 J1 S- h  n& h, hSecond recession is coming？
; l+ f# f( j' h! A# B; z2 ?2011-8-9 23:58
# w, Z+ `' s" [* R- Y+ ecancer may be from sexual reproduction of somatic cells.( ?( J2 S1 _1 y+ C4 M
2011-8-7 00:16/ H- K! [! G- O  T& u
who determine gene？ genetic determinism is fatalism！
# L; H: R) _6 P2011-7-30 11:26, U3 o; B+ [* w& ~, n3 ]! I
niche reprogrammabllity is the key of solving cancer problems...% i7 [8 A% g& \6 j
songtianlong: i can't agree more!!!O(∩_∩)O~ (8-14 20:42)8 f; V% [6 U1 T, a
sunsong7: hehe. thanks for interested in this topic, welcome future discussing (8-14 20:54)
& ?( Y. A8 k# `* j; m! C3 T% _2 p9 H2011-7-24 01:24
; h/ U+ |* K  j5 {; g2 }, [8 tcancer results from acquired genetics alterations.
5 l/ W" m4 G% ]% m2011-7-20 21:37! C5 V( z+ x3 C5 F6 i
CSCs are the low differentiated cancer cells in G0# N: D& r+ P; c- _
2011-6-29 16:30" P0 L: ?; ?. |4 t8 x% o4 d
iPS future——in vivo direct reprogramming ...0 q' F. \% M$ X9 h
2011-5-31 15:20/ c5 S. Y* p! A
niche reprogramming——cell fate will be manipulated by cytoplasm - microenvironment interaction http://www.stemcell8.cn/thread-40755-1-1.html9 d5 u9 `* Z0 N+ U0 t& E: \
2011-5-31 01:28
& c% c' f5 G4 x7 e8 [2 }  `all the somatic cells of Mammals are totipotent ！
8 C+ _! u/ K4 s; F2011-5-22 22:22
( \8 E0 `7 Z, F" P. gmiRNA——The manipulator of  cell fate！
9 W+ k# S2 x! {  q2011-5-20 20:213 I: D0 z- m( T
《Cell Stem Cell》means “cell is stem cell”   活细胞就是干细胞？
9 E$ C5 T1 \% o1 ~: H; f: X5 ~2 w2011-5-17 12:38
5 |$ u$ [4 |# E8 }6 |, _' {cancer —— good nuclear in bad cytoplasm！RNAs are cytoplasmic determinants determine  cytoplasm determine cell fate！ division is differentiation is cancerous is life ！6 J+ ^: l. S  R: {, ?
2011-5-11 12:31" J! I. n' N' F; g" {
cancer results from cell dedifferentiation...
' _  o" i( D$ V7 k6 v2 @2011-4-28 18:07
! z; N, H1 {* `8 ~* G6 D6 udifferentiation——asymmetric cell division ！
1 R# ?: U' D6 D, z2011-4-28 18:04
' H% p1 w  g+ ^) Z  d0 [8 c! mcancer origins from the regenerative cells！) f) b! H- O( H) N8 m5 ?3 H( e2 A
2011-4-28 17:52
5 f3 R/ a0 b+ B& k$ n/ H& }2 jProliferation is differentiation potentiality！
0 d& a* ~' ~1 I" _+ U( M3 ?; r& H: Q2011-4-28 17:49
) _1 y: k7 Z5 O8 uiPS——the key of Pandora box！2 L5 a9 j: ?) m3 m6 Q) P
2011-4-27 22:36
8 X" I' M$ r9 ZAristotle— "The whole is greater than the sum of its parts."" T" S" o9 K7 d8 J- O( @
2011-4-27 00:20
, K1 Z$ S- R7 V0 y/ v0 Jcancer——atavistic cells
+ W$ F: {2 Z  @# h; |2011-4-20 00:20
2 O) z; u" t% `" P! Ocancer——cellular atavism！6 u9 I  {. @- c! B7 h
2011-4-20 00:18* P: y/ x, _& J1 U  c
cancer——evolutionary ancestors of mammals.8 ~* r" u7 B! |! M- a( x/ C
2011-4-20 00:09# [4 h! [. L2 e$ K( X
肿瘤是细胞自组织缺陷的产物 % G9 p  s" g! E) A% j2 H0 Q
2011-4-17 01:41
9 r3 [# j5 r2 t. }3 Tcancer——Metazoa 1.0' Z4 [& ?4 M- y9 G0 d7 S
2011-4-17 01:00
4 ?% |6 M& N/ k5 N' SUS——the Axis of Evil！
0 S2 i, ~2 ]. `) p0 M2011-4-4 01:19+ F  d/ b0 j: ^& c0 y, Y
美国是世界的邪恶轴心！+ Z  D# S) E" U
sunsong7: 沁园春.血               ---作者：萨达姆   日 本 风 光, 千 里 地 震, 万 里 海 啸。 望 仙 台 内 外, 废 墟 莽 莽； 东 京 上 下， 顿 时 逃 逃。 核 站 爆 炸， 世 界 惊 涛， 地 震 海 啸 试 比 高 ... (3-22 21:25)/ J3 i2 M; A6 _4 q% ^
2011-3-22 19:067 p1 U) H2 J, G! }/ k0 Y; R7 ~. f3 Q
teratoma is derived from endogenous iPS！2 X5 ]% R6 K0 G
2011-3-15 21:44
& U, W; g( ~8 c% w9 f2 aips is a luxury gambol on  % Z/ H' ]% {/ I# P  _
2011-3-3 14:50% B; Y* ^9 l& w$ v  U  u( N
cancer is intermediate of species evolution) c3 N9 g% t2 b$ V
2011-2-12 12:29
6 j9 R% D% u8 G8 k  w! Ostem cell now is on the eve of coming medical revolution4 Z8 S4 [- v4 ]) Y' l# W# k
2011-2-12 11:20
1 H: u" _9 W2 dInflamation is the reprogramming process of somatic cell in vivo！
/ O9 H, r& D( N% g/ D. Y6 w2011-1-31 14:49
. [( y5 Z. j9 A: g9 lso-called medicine is niche regulator！
' U7 n( b6 W/ Z2011-1-23 21:45; g2 k7 C) z& D  ]" i& u; H
endogenous iPS is the cancer initiating cell！
& E" w# ^  Q; h: ^0 P1 ?8 M1 d2011-1-17 16:47  C: A; j. s+ O
cancer is unicellular organisms！0 V, ?' W/ Z4 e: J* M, {& f
2011-1-9 22:04
% O, h' [: K$ l* OPandorabox Has Been Opened# m% i) Z/ G- k% P9 ^$ b
2011-1-7 23:243 c' F# K9 C" J) w  v# L. d! }8 ?
iPS is the Emperor's New Suit ! % j2 t5 Y, O& W, ^% x' h
2011-1-5 23:50
2 E, O/ u! d7 _" wcell-free is the final solution of stem cell therapy
" w& p& F' Q$ _  A2011-1-5 21:46
9 p0 I9 }# R0 L" {6 V8 gniche is telling the story of stem cell..., ^* y. A2 D& r* e# R2 c$ Y
2010-12-29 17:32
; K3 `/ _5 Z. q# Tcancer results from reprogramming of somatic cells9 R% \2 V! I. G* ^! ^
2010-12-25 18:56
, e" O! k4 o9 V" m! v4 ~1 ycancer——good cells in bad niche！) h# d* ^0 i1 F+ F( Z, Z9 d4 `
2010-12-25 16:02
7 z$ h6 B6 o1 `, e* ^6 J+ a* z' `cancer无罪——制造产生罪犯的土壤才是真正的犯罪！
0 w$ M/ ~, B$ N" s) p* S, d& J$ Pderon: 灰常同意，有相关文献么？ (12-19 09:41)
4 y$ [& u4 [" _# m! H. J3 ?2 Vsunsong7: 呵呵，请来参加讨论——癌细胞的发生可能是一种“返祖”现象？ http://www.stemcell8.cn/thread-32073-1-1.html (12-19 11:33)
' H1 g- E. O! j( M  V" \sunsong7: 问题讨论 http://www.stemcell8.cn/forum-re ... 709-pid-246202.html (12-19 13:29)& @. g& f. g+ y6 q  J
2010-12-18 15:54
8 L: j" G# |1 v3 N$ N子曰：上善若水 大成若缺——干细胞治疗的终极解决方案将是不移植外源干细胞！! j3 k- s$ E) f+ Z  B
2010-12-15 15:07
' o  ~9 g1 s: ~0 u1 p; @0 I老狼的记忆——大洪水
4 f2 L2 d9 v' c2010-12-13 23:25/ T4 T, A  |" T& j
can cancer randomly differentiate into norml cell in vivo  
3 _) M' f' Q# \5 o' C6 m% D; r2010-12-13 22:33: \$ k* d' w. @9 c, a  `! ]+ [
omnis cellula e cellula
# w. x  ^: M; F2010-12-12 09:28
$ G5 r4 _4 a5 `9 P9 pStem Cell ——The Origin of Disease, a3 y% {6 f2 f
2010-12-12 09:27
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