老狼的个人空间记录

sunsong7

"genetic mutation" should be exactly as "gene self-editing"4 p& I0 V# s3 Q" M9 Y4 j
2017-12-1 13:17
2 F2 j# C3 y0 g7 KBioreactor in vivo would be the terminator of illness.
3 C) H% X3 _- C' x" W6 K% c" O2017-11-20 23:09
: n  K: \6 }0 c+ C4 R) Brenew tech：剔除衰老（病变）细胞占位可以恢复青春。" R' h8 j/ n4 R( _
2017-10-23 12:50! d1 [9 B5 O8 |! ?* u
魔不疯，鬼不魅； 道非盗，仙非妖；神无形，兽无极。
4 O  S, d4 Y5 R# \2017-9-30 10:58
' p* l5 v, @- a& ^( _! X8 XLife 3.0——from decoding and coding to reading and writing+ F; K+ I/ J0 J2 I' h
2017-9-21 22:328 J( M3 y# p2 H! Z/ N, v
理论创新：亮明立场——先颠覆，再完善
8 u; S. i9 m* Y$ m$ P  s2017-2-7 00:07
! ?5 e+ @- f/ ?+ S. E6 u0 I" K2 I干细胞第二定律：与细胞外基质共同构成多潜能；# C' R2 o- C  g2 [' d& i1 K% B
2017-1-3 11:14# m/ K5 q2 C$ o1 k- e3 l/ x
干细胞第一定律：全生命周期保持增殖分化能力；: P" S2 }( B7 g4 s% m9 f
2017-1-3 11:13
# v& X$ _  q3 wNgAgo——Never give A guideline operated！  c/ l$ z7 r7 H7 S2 ]- o0 X; x
2016-12-1 10:09
. S' c8 G& J" @$ s, V表观遗传—— 一切皆可改变  一切皆有可能% u' c$ l: B& I9 N) _
2016-8-17 23:37
# T0 n* B- f" ~2 ?子曰：吸血鬼疗法——养儿防病 养孙防老/ F7 J  z8 `  m- [( O5 z2 X# o
2016-5-23 12:05
" l, X7 g' D7 y0 UNgAgo——Debug tool kit for mammal cells
. @/ |& M7 c* Y( `2016-5-9 13:09, R, Q. n; o7 N' F, Y  G" l
公理之外 皆需证明； 科学命题 皆可证伪。9 _9 T' O" S7 g2 p5 S$ _  N3 T: c
2016-1-2 00:20% S# F# k6 \- p$ x6 U5 S
低氧——破坏线粒体功能、诱发炎症、导致基因突变
& T, `  R; m% d! _) i6 H5 A2015-12-16 20:19
- o. D; {. z( C6 H4 I) N* U7 \癌症——炎症部位组织再生过程中细胞去分化失控形成的幼稚化新生物。
/ c1 b4 }9 o: g  P/ |; Chcoohboy: 一个有趣的假设~但是没有炎症就一定没有癌症吗？ (12-18 16:16): t2 L/ o" a, T8 x4 ]+ Y
sunsong7: 炎症与癌症同在，Hanahan D, Weinberg R A. Hallmarks of cancer: the next generation[J]. cell, 2011, 144(5): 646-674. (12-19 19:45)
  N9 c" E- N7 @" Khcoohboy: 3ks~ (12-24 16:45)0 y/ I* {4 n) y: @8 X9 ~
2015-11-18 15:540 O. m# n& A+ m6 s
抽象世界与客观世界的真理判别标准是不同的： 在虚拟数学世界里，逻辑是一切命题的唯一审判标准； 在客观物质世界里，证伪是一切定律的最终审判依据。$ }; ^2 j. o$ t, H$ m
2015-5-20 14:130 S" A! l' _/ Q
传统生物学将死：进化论=自然神论   基因轮=宿命论   细胞论=活力论翻版。    现代生物学曙光乍现：系统生物学=数学 结构生物学=物理学 合成生物学=工程学
( l% ^! _, [4 ?# _helong: 系统生物学是把细胞、基因、进化、物理学、信息学（数学）、工程学等都打包起来的所谓新学科，目前只做到了简单组合，还没有达到系统集成阶段。合成学更多偏向于化学。 (4-21 19:28)
5 v5 D  g, [) H8 ~4 ]) X6 gsunsong7: 方向对头，努力总会有结果的 (4-21 20:05). h1 B: B& q; e2 }  E
2015-4-21 16:46
+ Y3 Y; t; m0 G$ {: u" Fsearch and research is just disassembling the creature.
1 S7 y3 X! @1 C0 ?8 f2015-4-7 17:01
/ g; B  t* x4 ?; N4 x$ N* }selection is  the act of intelligence
- J+ X; `2 @  n+ j2015-4-7 13:495 A$ ~7 r8 `" n0 h
Genome fusion create neoplasm' ~5 O) F) |9 y$ @# ^1 \
2015-1-20 13:10
3 n- a: R2 ?. l; x" b. M8 wSTAP——Stupid Trick  Against Professional " L; i  ]" ?' ?* B2 d  N3 H8 P- Y
2015-1-1 19:29  ]9 {, n& }9 H7 V7 d
information=structure=negentropy7 _9 X: K$ P0 e& H  s
2014-7-22 17:36% H2 d* ]  G' O
Natural mutation does not result in new functional genes - H' r8 R4 A! M; @: q0 r
2014-7-3 14:063 ]4 \/ S- w: z9 u! k' C' W5 r
life is wisdom creation instead of natural evolution. {3 w3 A4 L+ I/ c2 O+ }  p
2014-3-27 09:33
4 X7 m* q; D3 \+ Slet us explore the source code of life !
$ f' x: F! B3 j$ s9 T* d3 t2014-3-11 13:11
. {( a- X) y' b; b8 F  Obio-manufacturing——processing，machining，casting，printing，3D prototyping，duplicating，cloning，life replicating.
% g7 Z( [: W' \  H0 J2013-10-7 23:06
  A( Q* m4 u; ~& Zinduced abortion would give the key for curing cancer 9 y! f. }# Z' O2 O7 f6 ?( T/ |& ]
2013-10-2 23:33! E  K+ R/ U: ~# d" B  i0 ^1 z# ~
“key breakthrough” in molecular biology are entertainments% y' N, ~( ~7 s8 m7 e
2013-6-16 11:50
! |! V6 S1 Y. [/ {Rules Of Living：trial-and-error exploring，survival takes the legitimacy; G9 s+ w3 `. w, O9 \" C" W1 w- F% A
2013-6-16 11:27& e( @" L+ X. q- @+ V: p# C$ i, x
Life is a set of debuging programs
* N- T0 @8 G0 e9 @9 q- {: d9 O2013-6-15 18:40. B5 p! J& M5 ~9 I2 I, E
current biology is closed，destined and agnostic，it is  the only contribution is to kill cells" ]# K% s% f6 d
2013-5-2 08:54
! d% X: X) L8 W+ t7 }information，energy and construction are the new base stone of biology，instead of evolution，gene and  cell  tales
5 `) r$ r; U# Q% `- N# b1 j2013-5-2 00:51
# m" g8 q6 C; T) y( l% gvirus is the messager of  the universal life network2 w! z, s/ @' U% Z9 Y3 n5 H' X
2013-4-18 14:33; a# X3 j3 v8 m
Genetic information doesn't improve cancer risk prediction  X" T, o8 K4 z' y0 R2 m
2013-4-1 09:20
- L4 s  ^1 J6 ?- W3 s8 o4 D# e* ^There is no early diagnosis of cancer，but early prevention of it
+ M0 ?3 I2 a6 N, w2 Y9 z2013-3-27 09:17
1 |6 X5 I1 R) V( s" Phypoxia maintains stemness or carcinogenicity
" e; J9 L- V' m" r. o2013-1-2 05:21
3 I0 a+ Y  I3 d! }: q$ }/ Hcancer is the living fossil records on origin and evolution of human being. S6 L8 T! h3 |
2012-12-9 23:31
- o! r: p  `% b) `* Ninformation island results cancer8 R/ A. T: U5 S( v% ~; ~4 U
2012-12-9 05:23/ X# F2 e) h3 v, {/ \. d8 |
life is digital game6 I5 l! V; z" S; E4 y
2012-11-10 00:17' X* F5 i. L7 h: _4 y, Z
cancer ——severe abstinence reaction of cells to niche addiction0 m. M5 |/ j* s( r
2012-9-28 12:11
7 I) n0 X8 D) F! P6 L& C未来生物学终将回归物理(熵)及数学(分形)的美感. _# \$ k& R# ?9 p: R( \2 c
biomater: 熵理论适用于任务物质。。。。也适合于生命 (9-26 09:28)% F& b+ v7 q5 h" I& @' e
2012-9-25 21:223 W$ H' D3 ]) [* D# m% U. u
membrane holds the key to life
4 \9 d' }( G* m5 M+ E9 ~1 X9 \0 }9 ]4 |2012-8-19 20:246 g2 O  t' [6 ]8 U( g1 t1 d
Cancer is the default state of cells& K! p% D* x% B7 v$ d% ]) J
2012-6-26 22:17" }; W( V6 }) p" B* L! V$ h8 U
mainstream cancer theories could be overthrown！1 s" b7 a  M9 g1 u
2012-6-25 15:43( c9 f% Y9 u$ n$ j, W# b: `
carcinogenesis has nothing to do with the gene mutations but is  the result of niche reprogramming..., j, |% Q) W0 ~  i' ?
2012-6-7 09:36
6 j5 k# R7 q6 f4 f/ ^$ {every living organism connected with the water， one cell one world
0 V$ `! y* E& N2 l# K2012-4-19 22:061 J% h5 \5 J& x+ q# X3 d
chemical structure of cancer cell determines it's biological function...
( X: r# D5 s/ A' Z6 `6 h2012-4-7 17:56
2 R! o6 ~9 d  y2 e- mMann tracht und Gott lacht/ _6 [( V0 d; c; Y: _
2012-3-24 21:34; t% z, U6 T4 z  Z/ ~/ `4 c; M- I/ N
Darwinism or genetic determinism is a fairy tale！7 q! ^; B. u! k
2012-3-13 15:189 {; d- U1 p6 u& p# P  l5 Z
niche isolation is essential for cancer speciation& Z& J- e) o( q5 ^+ N
2012-3-12 12:07
/ {- @3 Z3 Z% l; a3 F9 ^2 AHybridization Creates New Species，Mutation results species extinction
# \" `5 I# i  q% g- u2012-3-11 18:21
) t4 D) H5 U  K4 T( ~ROCK may join the niche reprogramming...
+ P, F% p% A6 ^( Y" W/ Z; gyuhaoze: 这是篇文献吗？ (3-9 10:41)/ U3 n; ?3 ?; }5 \- V$ h0 d
sunsong7: http://www.stemcell8.cn/home-space-uid-6268-do-blog-id-1211.html 突破：病人体细胞及肿瘤细胞长期体外培养（附原文） http://www.stemcell8.cn/thread-51419-1-1.html (3-9 10:46)
( `! n* W8 h4 Lyuhaoze: 啊， 我看过这篇，还顶了呢，谢谢哈 (3-9 14:37)
3 q! S+ ~+ m+ W: P$ c$ o3 L- q2012-1-19 10:52
8 f! T& S& ^; {1 f( aoncogenes are pseudoscience9 v" l) r. \) l6 h! I
2011-12-29 13:55' g: n6 q3 N0 R; D0 V# |( P
gene mutation leads to variation or extinction, not new species  |" r# V4 ]1 ^2 o7 I: K6 \+ f! ?
2011-12-29 13:28$ E4 G& H7 V3 v) G( a; k/ D
oncogenesis is non-Darwinian event4 L/ K1 b$ S! v; M/ L5 s5 h3 K
2011-12-28 22:56- V/ c! S& r2 q  q
disorganization activate neurogenesis activate oncogenesis   / `  `3 K( N# m
2011-12-22 23:38! ~% t4 y* C3 L5 p" v1 P6 @
MSC is cell feeder，tissue scaffold，immune firewall and biological glue. Q- V0 t3 W5 g! n  n+ ]
2011-12-19 19:46
% w% {0 z( o; Scancer is Noah's Ark（species carrier and life explorer）
- N0 q2 |$ E+ A1 s& w4 k" }2011-12-10 09:46
% D- Y* y& G8 H' ~& F1 M/ K" _cell fusion create new species, gene mutation induce variation/ `! s/ D" K. c0 g/ s6 H% g
2011-12-10 09:36
2 P0 E4 g$ q/ t& N8 U2 ?GVT will be cancer terminator， Cytokine storm will be cancer preventor7 w* z& A" c, m* v0 `9 c( M
2011-12-8 12:569 k& g( U4 C4 Z3 G5 y
cell fusion results regeneration，reprogramming，neogenesis，atavism； cell division results differentiation，apoptosis，senescense，development;' w+ L2 U( b: g( S4 a' Z
2011-11-27 14:54
; [% u& J2 H3 [6 e" ?7 DCancer is between protozoa and mesozoa， not metazoa...
) L9 P2 e% J! `* f: i2011-11-27 00:254 t; ^% k2 L, h, n8 {" s" d2 j& G
cancer is neurological disease！ haha，I got it！
0 H' ~3 d" R/ m' [+ T2 {! \2011-11-22 22:06/ J: {4 I4 A6 b' l
you are cancer，fetus is tumor. 佛曰：汝既是癌 癌胚如来
2 \" R: s. |5 B: l1 ]0 T2011-11-12 11:27
2 E: M) r5 b/ V# y: Ucancer is the ecological invasion of hacker...
: V, `) m0 [' ^% F' Q2011-10-5 10:315 c/ W9 v7 R& Z9 A
microRNA is  negentropy？+ A9 w' p5 ?8 S7 R1 }: z$ S6 a
2011-9-24 00:48
1 z8 [5 W6 t9 E( X, e. c0 T$ h4 U5 z& wcancer is the social problem
+ \1 G  g4 i, a5 E2 g2011-9-9 23:33
% M$ k( W' R6 g- x  W. \8 ~Science is the games of nobleman or madman$ R  u5 ?, e+ [+ Q1 n
2011-9-2 15:03
! a' G: l) ~: y9 v1 D1 jcancer resulted from disturbance of biological liquid crystalline state of ECM
" t! y4 I/ f  C" K$ F+ Q2011-9-1 20:132 `: y1 U3 n" Q/ h
niche n-dimensions——space, time, momentum and entropy; energy, material and information flows; physical, chemical and biological factors；topological, thermal, and fractal influences...
) ~  a2 S& ~6 z% d, t- p; G2011-8-13 00:37* Z9 c2 _% B; Z; S( r
Second recession is coming？
/ q2 H. b+ z6 u- D/ A% [2011-8-9 23:58. Y' X: {" b8 K
cancer may be from sexual reproduction of somatic cells.& f* w' f0 r1 T$ |
2011-8-7 00:16
' v; u. }/ v1 {; {# y( U6 u% C! Ywho determine gene？ genetic determinism is fatalism！8 u* E1 Y& r0 q: L
2011-7-30 11:26
$ N: i3 J$ x& r- w% P0 Zniche reprogrammabllity is the key of solving cancer problems...
# ?; G6 x7 X8 Fsongtianlong: i can't agree more!!!O(∩_∩)O~ (8-14 20:42)8 C; ?3 b6 j: K, G6 S% _* S$ S+ w
sunsong7: hehe. thanks for interested in this topic, welcome future discussing (8-14 20:54)2 Z5 x$ A: e% O/ B0 I/ X
2011-7-24 01:24
* g+ A7 j& j  A8 b( X5 Ccancer results from acquired genetics alterations./ m! ^& V% a/ S2 e9 L1 {+ \
2011-7-20 21:37
6 B/ M- b: N" W. {' B- Q6 t1 iCSCs are the low differentiated cancer cells in G0
2 S( a" j/ |: x7 p2011-6-29 16:30) I. s! F& \# J: X' f
iPS future——in vivo direct reprogramming ...
' H# M+ J" h7 j! J; K2011-5-31 15:20$ T2 G) a( K' @  B
niche reprogramming——cell fate will be manipulated by cytoplasm - microenvironment interaction http://www.stemcell8.cn/thread-40755-1-1.html
; W. P; ?4 l4 j0 _2011-5-31 01:28( f# l$ [* H2 B; z* Q5 }; g
all the somatic cells of Mammals are totipotent ！
$ g% A8 z# q5 Q7 O3 F2011-5-22 22:22$ k+ n, v+ F6 ~/ n" o4 p
miRNA——The manipulator of  cell fate！" F5 S( U1 q4 F' t3 a7 A
2011-5-20 20:21
  K) V3 C& M, D( H: [《Cell Stem Cell》means “cell is stem cell”   活细胞就是干细胞？% J% X7 ?0 x+ Z7 Q. Z% ]4 w1 p
2011-5-17 12:38
5 U0 T& O! V. Gcancer —— good nuclear in bad cytoplasm！RNAs are cytoplasmic determinants determine  cytoplasm determine cell fate！ division is differentiation is cancerous is life ！
* p0 o, E; ^" ^2011-5-11 12:31
' z5 H/ R; l& S7 j( C( ~5 z6 ^+ ]+ ycancer results from cell dedifferentiation...
( R! r9 J6 P) J' o2011-4-28 18:07
2 M2 B( V/ x- M( s4 Qdifferentiation——asymmetric cell division ！
" T! s2 m4 A3 _  `1 Q+ O2011-4-28 18:048 F7 j0 F* ]' [: B6 w% K3 I
cancer origins from the regenerative cells！
1 c3 `5 R  r- I9 ^* C) j4 x2011-4-28 17:52
0 O8 p0 ~/ _) I+ s, a7 s' xProliferation is differentiation potentiality！4 N( \& x% Z/ _! [, _5 L* H
2011-4-28 17:49
" o; N/ u/ l" U) diPS——the key of Pandora box！  o4 F6 b% o/ ~+ x1 D
2011-4-27 22:360 U( o# j7 t) Q6 K+ ^6 f
Aristotle— "The whole is greater than the sum of its parts.". v0 {$ \9 A9 _6 j1 I) {9 ?: H
2011-4-27 00:20
. |. k% L7 T) ^. b9 l: Wcancer——atavistic cells
8 ~, I% I/ T; X2011-4-20 00:20
! P( w7 X" ^# J* E* `, R9 ncancer——cellular atavism！" G( F. `6 u4 }) w  h# L) m
2011-4-20 00:18
2 D4 U$ b! ^3 I$ b: `$ C/ kcancer——evolutionary ancestors of mammals.) f9 |) }, g! b9 ^% d6 j+ p# g, l
2011-4-20 00:091 O+ D# h0 W& D: J2 w5 p
肿瘤是细胞自组织缺陷的产物 5 a9 K: q: P5 B
2011-4-17 01:41
/ H: ^6 A( w$ G& Acancer——Metazoa 1.0  A# j9 s: S( d$ k& L
2011-4-17 01:00: J9 y2 V. I+ p6 ]
US——the Axis of Evil！( X. R" ^, N' [  V# `) L
2011-4-4 01:19! h8 ~# s0 B3 T9 z: ^! d, Z
美国是世界的邪恶轴心！9 g7 Y% S! n0 H& M" K
sunsong7: 沁园春.血               ---作者：萨达姆   日 本 风 光, 千 里 地 震, 万 里 海 啸。 望 仙 台 内 外, 废 墟 莽 莽； 东 京 上 下， 顿 时 逃 逃。 核 站 爆 炸， 世 界 惊 涛， 地 震 海 啸 试 比 高 ... (3-22 21:25)
& ^  s# C7 X% x, W2011-3-22 19:06% b) Q: ]% k3 y1 H
teratoma is derived from endogenous iPS！
1 z' x# b& |8 [  E( r2011-3-15 21:44
1 Y: E: @  X! ]3 q, G& `3 k* hips is a luxury gambol on  4 U4 z: j  [! N7 G3 u& i% Z
2011-3-3 14:50
) `2 T# }7 Y) x! \# R1 ~cancer is intermediate of species evolution5 Z; k% W$ c5 z+ I) L" ?
2011-2-12 12:29
/ `9 N9 M/ A! Wstem cell now is on the eve of coming medical revolution6 p9 D+ F, p5 C4 ^, b& E: y8 @+ y& ?
2011-2-12 11:20
$ d4 @. v) d/ [$ T7 r6 L8 YInflamation is the reprogramming process of somatic cell in vivo！: P+ o/ v3 S% e6 |1 v+ r
2011-1-31 14:49/ E. y3 E  H) l3 _+ D
so-called medicine is niche regulator！
; D9 N! G" O' |* e" g2011-1-23 21:45/ ]6 q, R8 f: c! ?; _
endogenous iPS is the cancer initiating cell！
6 Q" A* _' `. x8 E2011-1-17 16:47  A; I, H8 M1 Z
cancer is unicellular organisms！8 @$ f! g+ u6 l7 Y6 u2 _- @
2011-1-9 22:04
4 f- b7 |: L# v, g! v3 F* Y: r! oPandorabox Has Been Opened: u! H$ {) Z* m  x
2011-1-7 23:24
0 t3 ^) P0 H! v+ z1 V+ DiPS is the Emperor's New Suit ! 0 p+ N2 f! e! u/ V
2011-1-5 23:50
/ V& V% Q. P- M) ycell-free is the final solution of stem cell therapy5 s6 D  A  v, w  E. i- v9 z
2011-1-5 21:46/ }+ i; ^% |  [6 N* H4 F7 K- x
niche is telling the story of stem cell...9 {2 G1 S2 [9 o4 U" r; W4 Y
2010-12-29 17:32( `3 Q/ u5 J, Y* G% ~; i' y1 |
cancer results from reprogramming of somatic cells4 \7 A8 \0 r7 M8 @6 U9 O4 A
2010-12-25 18:56
: C( a* c( E8 C3 q& n1 w5 Wcancer——good cells in bad niche！
' W4 g, N4 L& E; Y2 v! A+ {2 b2010-12-25 16:02
/ N# P, N- T% H- _2 w  Acancer无罪——制造产生罪犯的土壤才是真正的犯罪！
% s- R( Q  \5 e) L/ F) ^" u: s6 L! x$ Qderon: 灰常同意，有相关文献么？ (12-19 09:41)
9 h7 |6 r' ~/ ]6 a# ~sunsong7: 呵呵，请来参加讨论——癌细胞的发生可能是一种“返祖”现象？ http://www.stemcell8.cn/thread-32073-1-1.html (12-19 11:33)
. E; u+ |* I+ z' J# k$ }+ ]sunsong7: 问题讨论 http://www.stemcell8.cn/forum-re ... 709-pid-246202.html (12-19 13:29)
# P) W! q5 x* w3 r2010-12-18 15:544 Y; u( T& K' u; e1 ]8 M7 I2 y
子曰：上善若水 大成若缺——干细胞治疗的终极解决方案将是不移植外源干细胞！
6 \2 j5 P; S' t2010-12-15 15:07
: Q* V5 J4 {0 \' ]  s老狼的记忆——大洪水
$ M, a' n3 C! }+ x! O2 _2010-12-13 23:25
: G' c  C. r; S' Z) {& Ucan cancer randomly differentiate into norml cell in vivo  
: v" p- M* v7 S5 `: F4 k2010-12-13 22:33) t$ o2 m: Z& [) c4 N) u( }" q
omnis cellula e cellula) j7 s& o" ]  a9 {1 l) ]
2010-12-12 09:28
5 b/ ~; h6 O$ O$ v" w& m: H( m: ]Stem Cell ——The Origin of Disease
5 L, ~. m  _" \2 S  b2010-12-12 09:27* ]8 Z$ k' ^* `9 K6 Y6 Q6 _

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