质疑tbx18心脏祖细胞全文

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Tbx18 and the fate of epicardial progenitors
9 E: G% z) o" |* K4 SArising from: C.-L. Cai et al. Nature 454, 104–108 (2008)5 o% V( Z6 y; l( m! F3 ^3 y( A. P
Uncovering the origins of myocardial cells is important for understanding' v1 y6 d& y/ g% m' @
and treating heart diseases1,2. Cai et al.3 suggest that Tbx18-! u0 k% S  p; K/ B
expressing epicardiumprovides a substantial contribution tomyocytes
# }2 S/ B3 D( v! J% }+ S" j& Y+ vin the ventricular septum and the atrial and ventricular walls. Here we7 W+ r" l; y  D9 p$ c$ t0 M
show that the T-box transcription factor gene 18 (Tbx18) itself is7 S* m* ]: T! R8 q! f
expressed in the myocardium, showing that their genetic lineage
# {# E! [6 \. I0 mtracing system does not allow conclusions of an epicardial origin of; N$ F" X9 s7 e$ O& |" w
cardiomyocytes in vivo to be drawn.

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