PDF电子书：Current_Protocols_in_Stem_Cell_Biology

guokeyi

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+ b) Q" N  a% ~. a4 UFOREWORD
, d5 ^. O) O2 J% h" o. GStem cell biology is emerging as a field in biology with tremendous therapeutic potential.
% q" t) J6 M& @& ?8 q0 p& O. Q) RMaking this potential a reality requires an international effort. The recognition
: z. I& {- z& r8 v/ Xthat such a promising yet multifaceted discipline needs fostering led to the establishment0 |- W1 ]0 u3 q( |1 V) H. i& `
of the International Society for Stem Cell Research (ISSCR). Central to the efforts of the
  u) Q7 U9 i) V8 x( Q+ j! _ISSCR is the development of tools to ensure the success of stem cell researchers. What! N$ k9 k7 \5 ]+ l
better way to do this than to collaborate with Current Protocols to develop this valuable
, w' {# [4 \8 \# f  gcompendium of protocols in stem cell biology?; Z2 j* [: I/ N+ @* P1 z
Stem cell researchers have developed a number of breakthrough techniques, from the
' u& G+ i  n! z+ n" Fderivation and manipulation of pluripotent embryonic stem cells to purification and* {, p9 E$ o8 d+ A5 O* d" J
transplantation of tissue-restricted stem cells from adult organs. A number of laboratories( k5 P. K1 r- y& P, o
have become leaders in the field as a result of developing such techniques. The more
. z9 u+ ~; H- }2 b+ I7 |efficient scientists are at implementing new and powerful methodologies in their own
8 M) [( T# Q  t( p# p0 @$ elaboratories, the faster stem cell biology will advance our understanding of normal, _& R$ H- F' n' C+ v$ t
development and lead to the development of therapies. Thus, the availability of quality
$ U: ^. m3 o6 S; n# \# y- u7 B! ^protocols will have amajor impact on the success of the entire field. Current Protocols has
2 F3 _3 b9 P2 L$ k' x! elong been the premier volume for proven in-depth protocols regarding many aspects of. ~" v4 |. i3 Z
biology, and this volume on stem cell biology will prove a valuable addition to researchers9 X1 ~: m/ H' G0 R' A6 o5 |
worldwide.
) ?& v) F- N4 }7 |6 Y1 U' E0 FExperiments in stem cell biology must be interpreted with great caution as well as  c: U0 i, H) L( X6 |& H' e7 o" _4 k3 T- n
openness to alternative explanations. For example, the recently discovered phenomenon
7 p5 w5 L/ {. M9 kof cell fusion in vivo or the existence of tissue-restricted blood stem cells in peripheral
9 D. j. D7 _7 J$ H( D6 stissues were initially misinterpreted as evidence for stem cell trans-differentiation.
' ~- i% e  W/ C% zIt is very important that this compendium of protocols highlight potential pitfalls as well
. E' s2 O! y; Bas maintain the opportunity for clarification and correction when the need arises. The
0 x+ r$ E2 Z$ z9 T: Ofact that these protocols will be provided online will help ensure that researchers always
) l, B- m; h5 `6 O; x0 @have the latest, most up-to-date protocols available to them.
! |$ y: E0 x2 n. n+ _2 nThe stem cell field is burgeoning, and, as I have seen within the ISSCR, there is a genuine6 r+ T+ H& }* A$ C" }# E1 n
push to share information and interact so that the field can move forward quickly. There2 U3 m: G9 X( X% b$ T! d4 A
is a drive to develop not only excellent basic research skills but to bring the findings
1 U( B, r" H  d3 qto clinical use so that patients can benefit. As a Hematology Attending Physician at( T% G6 ~) O8 G. H$ a1 w+ m
Children’s HospitalBoston, I treat children who have pediatric blood diseases or leukemia
, @/ d* L7 h( d# z1 o: E+ w2 I- Eand am drawn by the need to translate our research findings into therapies to help treat a
" e# g6 J9 \" A3 q, g8 Lnumber of diseases. The promise is great, but we need to deliver, and I believe Current; {1 b' T' n4 K5 B- U( j6 j. x
Protocols in Stem Cell Biology will help tremendously.
, c3 w- C0 q& D& d/ E& r: CLeonard I. Zon' }) R( v6 B% V( W9 M* e
Current Protocols in Stem Cell Biology4 l1 z6 g( |7 A& R  v2 x& }
Published online June 2007 in Wiley Interscience (www.interscience.wiley.com)., f; ~' t5 Z, N/ S. g* e  n
DOI: 10.1002/9780470151808.scfores1
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2007 John& P2 S0 Q- o% U" b" |* M) U* Z
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xiaodongqin

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Jonathan

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zpzp0312

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zisu_yu

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王乾

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horst

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dragon513

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