iPS与疾病模型的12篇文章！

linlicau

分化但未观察到疾病表型的：3 j/ {, ?: J& f8 E) @5 M- h9 x; w
1.        Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).
2 S9 m5 m& n8 I: ]' d神经疾病：
( F9 s8 G1 T% D2 t/ R2.        Park, I.-H. et al. Disease-Specific Induced Pluripotent Stem Cells. Cell 134, 877-886 (2008).
9 Q8 b. ~7 ?: L神经疾病：
4 M1 }! n7 [2 {3.        Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009).! [; q4 s# U# F; ]& u& c
神经疾病：
& A, J: n5 o% T( b5 f  R" \1 ^4.        Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).
# _$ |* g7 h( T7 n/ k8 }糖尿病：3 I. E! F7 a( L# }
5.        Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).2 r' a$ o7 y! ?) V' P) n  b
血液疾病：
* b- D& S7 q' v9 A6 [; p, d6.     Yang, J. et al. Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. Journal of Biological Chemistry.6 E# N  W+ V0 T7 w9 O: ]: D
genomic imprinting disorder：9 O8 j. f& P# j/ ?- {5 d8 g4 w

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9 j6 R- ]% j& A$ m0 ]1 D, y成功观察到疾病细胞表型的：' d; ?0 r8 ?' I* \# m$ z; w
7.        Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).2 B5 f- Y+ O' l) w% n
神经疾病：- J" s9 I5 g9 Z$ b; z3 w& C
8.        Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009).
2 s# h6 f- l0 m! m  i3 I神经疾病：% E0 D" J$ p+ ^! e3 O" ?7 @5 |
9.        Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).! A' ^( S% _* Y8 c2 J/ `
血液疾病：* g# Q9 l) k% H- B3 j4 Y/ M' P- s
10.        Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010).
8 Q+ I6 ^# W5 A2 Q8 T; C% Z7 E肝脏疾病：
4 B6 W  C" |7 `& Z11.        Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).7 T4 N& Q! L& y, f2 q& J: o; y: f
心脏疾病：  A8 f1 w0 g1 @9 C' M0 n! E" k
12.        Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010).
  l" {0 I( X, S6 b肝脏疾病：7 z6 x' k* r5 t% v0 i

/ C% A, {0 H# s8 K望细胞海洋多加威望和包包啊~

linlicau

回复 1# linlicau 1 N8 X/ a; X  `  x6 `( W
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外加一篇：
- O, R  v; u  T& C& @* g13 Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome4 ?* I- l# _6 a
LEOPARD syndrome（豹斑综合征:遗传性皮肤病合并肥厚性心脏病。最后重现疾病分化的是心肌细胞，）：

linlicau

回复 2# linlicau ) u. ^) g! p" v5 j  y0 y, i* v3 }
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7 ^& [4 Y( k7 C+ U" r14.(最新Cell Stem Cell) Friedreich’s Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA,TTC Triplet Repeat Instability
" W+ w# b4 g. `8 k& W, gFriedreich’s Ataxia 弗里德希氏共济失调 在iPSC中发现(GAA)n 延长，与疾病模型一致。并且验证了部分机理。
2 W3 z1 y% \$ V原文：

乳杆菌

谢谢~~

hai1986

谢谢总结

marrowstem

极好资料，谢谢分享。

大笨鸟

谢谢分享

jane1lee

谢谢分享，很好，很强大！！！

艾心痕

谢谢，感激涕零！

苏眉1989

真的找到了。谢谢你们