iPS与疾病模型的12篇文章！

linlicau

分化但未观察到疾病表型的：7 x& S9 m/ J6 ?# i0 |& s
1.        Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).
" |9 ^3 B% [$ c6 H5 ^/ c神经疾病：& z" ]1 d2 B# J
2.        Park, I.-H. et al. Disease-Specific Induced Pluripotent Stem Cells. Cell 134, 877-886 (2008)., H7 m7 S! ?& ?, t' z3 |8 i
神经疾病：
- {7 A" _; ~: O( m7 f- D: g& q3.        Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009).
# q! \5 ~' l) W/ I1 ~7 l9 Z% y神经疾病：
) E# R, l/ K$ B3 Q4.        Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).* I2 P0 n* [1 T9 X  F- @
糖尿病：
6 s% u. q8 Y1 Z3 o* b  K+ f1 J5.        Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).
6 s9 {6 N# Q1 s; Y# S7 G: u/ a# V+ O1 L血液疾病：
" R6 |$ g1 P1 ^! Q$ A6.     Yang, J. et al. Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. Journal of Biological Chemistry.% N+ x2 L* H% X! R  I
genomic imprinting disorder：
$ ]; x( ]" g4 g% i) I
2 Q+ w5 k% l  U! _& [
( S; e! `+ ~% @3 O9 f0 B4 x9 G! j成功观察到疾病细胞表型的：7 I1 g/ ]( A0 F( X$ x5 u
7.        Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).) @, Y& a& m. L" m
神经疾病：6 Q. P, U+ [' }2 E
8.        Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009).  S+ g, n2 |9 H3 n; `! k
神经疾病：. A1 Z8 _% U7 R* C, j' B
9.        Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).
  |2 u( U/ S. z; i5 y血液疾病：0 h5 @6 T  U/ m4 A1 s1 K  [
10.        Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010).: [+ j9 N& L6 `
肝脏疾病：
1 Y5 S0 \- |" z11.        Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).- `8 g7 S+ r, p1 F* p
心脏疾病：, t1 ]4 f( c. z! y- o5 G& v
12.        Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010).
  n7 f0 R/ i) c! P肝脏疾病：
8 J3 ]' A1 m1 g' z( K! k8 O: y. }. d. M' |5 N
望细胞海洋多加威望和包包啊~

linlicau

回复 1# linlicau
. G' Q0 {6 s1 V/ l( `; j( P9 _0 [# A8 p
外加一篇：
9 }1 }7 R  K  k( c3 M# p* [: H13 Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome& Q. ^& F9 q+ a0 _& b5 w# s
LEOPARD syndrome（豹斑综合征:遗传性皮肤病合并肥厚性心脏病。最后重现疾病分化的是心肌细胞，）：

linlicau

回复 2# linlicau
( ?2 z6 O" f3 J# V
+ h( B& o( M3 h% ?
$ f9 V% q" [& l' V14.(最新Cell Stem Cell) Friedreich’s Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA,TTC Triplet Repeat Instability
0 a- p, ~% X) qFriedreich’s Ataxia 弗里德希氏共济失调 在iPSC中发现(GAA)n 延长，与疾病模型一致。并且验证了部分机理。
) P: c$ u5 m' ~: g, j' i原文：

乳杆菌

谢谢~~

hai1986

谢谢总结

marrowstem

极好资料，谢谢分享。

大笨鸟

谢谢分享

jane1lee

谢谢分享，很好，很强大！！！

艾心痕

谢谢，感激涕零！

苏眉1989

真的找到了。谢谢你们