iPS与疾病模型的12篇文章！

linlicau

分化但未观察到疾病表型的：$ t% _. N8 I% L: [
1.        Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).
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2.        Park, I.-H. et al. Disease-Specific Induced Pluripotent Stem Cells. Cell 134, 877-886 (2008).2 k; Q7 k  L  p0 ?
神经疾病：
* Q7 ?1 K) d- t: c3.        Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009).. {' B$ l8 t9 W
神经疾病：- C3 I1 D' ?2 o% |+ I* w+ @
4.        Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).; p* b3 J0 E0 [1 w7 R' j
糖尿病：
8 J3 S" W  X4 @" d. e, d& T5.        Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).) ~8 y4 g" d$ h
血液疾病：; Q( V8 F" t' m! r) v' N
6.     Yang, J. et al. Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. Journal of Biological Chemistry.' B; u1 e' e4 s5 H8 ^3 C
genomic imprinting disorder：
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成功观察到疾病细胞表型的：; u# r4 @2 P* ^4 G; ?7 c
7.        Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).2 F) }& P, i% X3 ^8 t9 x
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8.        Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009).9 Y  k5 T# L1 G# V. y' w
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9.        Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).! e- u  U0 W% M* p$ r7 g7 I: a
血液疾病：
: _" J- |$ a( e6 [2 D6 l10.        Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010).
" ?) O, v6 y4 ]  L& f! X, Q7 K- p+ p1 D肝脏疾病：5 l7 R, Q5 D' \0 U" a9 k  _/ _
11.        Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).! f* @8 }& k( U2 ~7 m6 D
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12.        Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010).
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望细胞海洋多加威望和包包啊~

linlicau

回复 1# linlicau
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( V; B& R% g% T  G$ P, k外加一篇：8 Z3 b  E6 K7 K: Y) u8 V  h
13 Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome5 J8 a$ j; ^. G8 Q+ h* N. D) y
LEOPARD syndrome（豹斑综合征:遗传性皮肤病合并肥厚性心脏病。最后重现疾病分化的是心肌细胞，）：

linlicau

回复 2# linlicau
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14.(最新Cell Stem Cell) Friedreich’s Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA,TTC Triplet Repeat Instability: J) f& F: H* n4 m$ m- o8 P: @0 b
Friedreich’s Ataxia 弗里德希氏共济失调 在iPSC中发现(GAA)n 延长，与疾病模型一致。并且验证了部分机理。: l2 `3 e: h0 T8 |
原文：

乳杆菌

谢谢~~

hai1986

谢谢总结

marrowstem

极好资料，谢谢分享。

大笨鸟

谢谢分享

jane1lee

谢谢分享，很好，很强大！！！

艾心痕

谢谢，感激涕零！

苏眉1989

真的找到了。谢谢你们