2008年Cell杂志的一期不错的干细胞特刊

yusheen

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4 Y/ a8 ~5 O; C' K" f4 n4 R% h最近浏览期刊，发现2008年Cell杂志有一期干细胞研究的综述，内容非常全面，感觉对大家非常有用，可以作为教材来研究学习。下载时把文章的补充材料也下下来，供大家学习。
! @, q( l: Z! ^: g7 A1 X; Y$ F) GStem cells have two remarkable abilities: they can self-renew to keep the stem cell pool replenished, and8 e( t1 i) f  ], }0 k
they can differentiate into a wide variety of cell types. This stunning biological duality intrigues not only
8 \; L7 H0 L( P. }4 hthose interested in the basic mechanisms of development, differentiation, and reprogramming, but5 ~9 y) U3 G  i+ M: f3 a" A6 D5 M
also those who seek to use stem cells therapeutically to replace lost or damaged tissue. But when did
; c! x3 v6 J. q% \" Y6 Xthe stem cell revolution start? It was back in the 1960s that two Canadian researchers, Ernest A. McCulloch
8 u0 l( v4 }5 Wand James E. Till, launched the field of stem cell research with their groundbreaking work on the hematopoietic
( m. J* I& [2 V2 {2 I# E7 zstem cells of mouse bone marrow. By designing clonogenic assays to measure stem cell differentiation
* x5 @/ J) t+ a( h: _in vitro and serial transplantation assays to study stem cell repopulating ability in vivo, Till and
2 P. V4 q+ d6 Q& D5 k! WMcCulloch defined the hallmark characteristics of stem cells.
* }$ U+ w( p" ^1 f/ \% _The field of stem cell research has come a long way in 50 years, as we hope will be apparent from this
. W1 U- N: v) r" Y1 iyear’s Special Review Issue. Our goal in this issue is to highlight the remarkable biological features of) t' R" H9 p( p* D9 b+ z" y7 Y0 \- g
stem cells, the molecular pathways that control these characteristics, and the ways in which these enigmatic
8 }" i  w+ a( scells can be exploited for cell replacement therapy. We would like to thank the many distinguished
4 t$ \& p& C1 ?9 s2 ]7 k" Sexperts who contributed their time and efforts as authors and reviewers to make this special issue on) ~* W1 P" w# Z# Z  |2 l
stem cells informative, thought-provoking, and timely. We hope that this collection of articles conveys
$ _; z) X/ }: t* ^: `; n4 D/ lthe excitement and promise of stem cell research, as we enter a new era of possibility.

yusheen

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顶一个

chuanbaozang

赞一个

exin11

看看

flydayzhu

look 一下

linlicau

辛苦了，要点包包也能理解。

ayeqiu

下载看看~

ayeqiu

为啥每次都提示“你所在的用户组无法下载或查看附件”…………晕！晕！！晕！！！……

tpwang

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你的积分还差9分就可以成为注册会员了，加油。( c* K2 Y9 P3 x( n

! L, m3 D) M: P* |+ d, |参加一些讨论是增加积分的最好办法。

ayeqiu

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1 j  ^4 X2 `  Z7 A* ^" ^8 u8 s原来是这样啊，谢谢你！