成骨细胞分化和体内骨形成

botizhou

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皮搋子

真是一篇挺好的文章，可惜的是lz也没有做介绍，就这样真是明珠蒙尘。
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2 w$ h1 K" b1 n' aStrontium Enhances Osteogenic Differentiation of Mesenchymal Stem Cells and In Vivo Bone Formation by Activating Wnt/Catenin Signaling
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) ^) H2 L! N0 w$ m5 G% |9 g: i$ IFAN YANG, DAZHI YANG, JIE TU, QIXIN ZHENG, LINTAO CAI, LIPING WANGa a" ]+ t, Q. l6 O6 C* D

: M+ `3 w; X- n2 j/ tResearch Center for Neural Engineering, Shenzhen Key Laboratory for Neuropsychiatric Modulation,Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China;
  x$ ]1 _8 B- p# }: ]% IDepartment of Orthopaedics, Union Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, China;0 M  q+ C1 ?, o+ }
Shenzhen Key Laboratory for Cancer Nanotechnology, Shenzhen Institutes of Advanced Technology,1 R) O# @3 K  d5 g
Chinese Academy of Sciences, Shenzhen, China
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    Strontium ranelate is a newly approved drug that can reduce the risk of vertebral fracture, which is attributed to its dual function in increasing the bone formation and decreasing the bone resorption. Strontium-containing hydroxyapatite was also demonstrated to stimulate the3 \! {/ b, b4 g! s, z% n
osteoblast activity and inhibit the osteoclast activity.However, the molecular mechanisms of strontium underly- ing such beneficial effects were still not fully understood.5 G" n' `$ a  e; q" u8 l4 }. Y
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   In this study, we investigated the effects of strontium on the osteogenic differentiation of human mesenchymal stem cells (MSCs) and its related mechanism; its osteogenic potential was also evaluated using a calvarial defect model in rats. We found that strontium could enhance1 I7 S* ^( M# }& Y& t
the osteogenic differentiation of the MSCs, with upregulated extracellular matrix (ECM) gene expression and activated Wnt/b-catenin pathway. After transplanting the collagen-strontium-substituted hydroxyapatite scaffold into the bone defect region, histology and computed to mography scanning revealed that in vivo bone formation was significantly enhanced; the quantity of mature and remodeled bone substantially increased and ECM accumulated. Interestingly, strontium induced an increase of bcatenin expression in newly formed bone area. In this
; X0 R4 t4 h+ L. h5 Z0 N( Y; wstudy, we showed for the first time that strontium could stimulate the b-catenin expression in vitro and in vivo, which might contribute to the enhanced osteogenic differentiation of MSCs and in vivo bone formation. STEM CELLS 2011;29:981–991
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lifangamanda

哈哈，花了2个包包下了！以前似乎看到过！

lifangamanda

谢谢楼主呢！