再来一本病毒学经典--Virology:principles and applications--John B. Carter

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Virology - Principles and Applications% @# O& j3 |5 U+ ~0 l1 d9 Y' n
Dr John Carter (Liverpool John Moores University, UK), Prof Venetia Saunders (Liverpool John Moores University, UK)
' c, e$ ^1 {7 V5 @8 GAugust 2007, ©2007; s- M4 Z0 F% ^: z
by Dr John Carter, Prof Venetia Saunders
/ D9 j3 s/ A( S* _  x. tISBN 978-0-470-02387-7: J" g  I1 \8 H/ I/ e- }
Preface.
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0 T; }% h  w( Z8 h4 u8 oAbbreviations used in this book.
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Greek letters used in this book.4 O0 l* G* w6 F1 V) e5 R' F  R

" B6 ~! m! p9 Z) M4 mColour coding for molecules.
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" J$ \/ c4 i5 e  A1 Viruses and their importance., i4 N$ N: _7 p* m+ p: ]. K! n5 l
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1.1 Viruses are ubiquitous on Earth.6 Q" N  P6 q9 N) L5 ?! m
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1.2 Reasons for studying viruses.2 F* t# [7 f8 A6 N6 z2 @6 A+ ]$ x

, t$ d. t% P9 S0 m; }/ u1 \' ]1.3 The nature of viruses.9 n$ S. c  W# i3 T; T
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1.4 The remainder of the book.
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& G( T) T6 J' v% W3 x! S/ X2 Methods used in virology.
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. y  L) j! R5 a/ H& b2 P2.1 Introduction to methods used in virology.& K' y2 }' S* U  H1 V" c6 ^

* ~- E& W8 K; I0 M& m8 v2.2 Cultivation of viruses.5 C) n( m& y8 D' p/ L: ^

$ h1 l8 t' J' P) o( w# i; K( f2.3 Isolation of viruses.- `2 H: \, h/ a1 s0 p5 f
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2.4 Centrifugation.: l. t% v/ V$ A; p% Z4 C
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2.5 Structural investigations of cells and virions./ d! \7 A* p7 k. }

, x; B8 D$ Q2 w/ k! k0 Z2.6 Electrophoretic techniques.  g- _$ |) P, k0 a) C1 o
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2.7 Detection of viruses and virus components.
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2.8 Infectivity assays.- Y% U: e( K! r) N  z
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2.9 Virus genetics.
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3 Virus structure.- `, ?8 R" @) ~0 ~$ [$ t+ u

- J" y2 v3 X9 O3 U3.1 Introduction to virus structure.1 ]0 V+ C2 U" Q# Z8 ~; B
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3.2 Virus genomes.: y& \7 M' y: c2 w
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3.3 Virus proteins.) i9 K* z' D0 X6 j! P1 H
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3.4 Capsids.
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3.5 Virion membranes.
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: f9 l. z7 p! |+ M3.6 Occlusion bodies.
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3.7 Other virion components.
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4 Virus transmission.
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4.1 Introduction to virus transmission.
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# r3 j" J; Y# w4 I0 \* _; S, a4.2 Transmission of plant viruses.' x4 d+ h& K. Q& Z  \

2 b( f: {- k" j4.3 Transmission of vertebrate viruses.+ m  |$ l1 J. S' N
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4.4 Transmission of invertebrate viruses.6 s/ o8 ?7 u- n' E+ a$ ]% @
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4.5 Permissive cells.
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8 f; A! {7 x" [/ n5 Attachment and entry of viruses into cells.
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, c7 d7 u8 r1 B" K5.1 Overview of virus replication.
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5.2 Animal viruses.
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5.3 Bacteriophages.
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% v" [9 p5 F& B# e9 V+ h% S6 Transcription, translation and transport.$ E" \6 t  L# S2 f# x
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6.1 Introduction to transcription, translation and transport.) ^7 a& Y1 _# ^' L9 E% M" I
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6.2 Transcription of virus genomes." @# G: l0 `- `- \. h- c
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6.3 Transcription in eukaryotes.
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9 s# J! t/ y* h9 A" R" i8 x* G6.4 Translation in eukaryotes.
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6.5 Transport in eukaryotic cells.
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% |' M/ v' M; n3 U6.6 Transcription and translation in bacteria.! ^  ?+ v2 `# m/ R+ b: T$ `+ a! X

" g# K2 z. q8 j( @: l( d  W+ l7 Virus genome replication." Q( X$ X) v9 g3 m% z

2 E- D, h4 |; M0 Q& o& h7 [1 T7.1 Overview of virus genome replication.+ A# R! |1 `" X) o% \. I( A

3 W: `3 l8 g' x7 }0 w7.2 Locations of virus genome replication in eukaryotic cells.
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7.3 Initiation of genome replication.1 @6 E: `( o, {7 M& Z
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7.4 Polymerases.  \9 ]) W) {& C) \1 c$ Z4 z
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7.5 DNA replication.9 _: D7 I0 v" F3 Y
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7.6 Double-stranded RNA replication.
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" B5 U. _/ W( J/ o1 ^5 D$ ~$ v9 e7.7 Single-stranded RNA replication.
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7.8 Reverse transcription., m; `7 S& S" S1 A( V  V& M- r; K% o4 ~

4 |9 g% E4 G( X0 |: Q4 ~8 Assembly and exit of virions from cells.
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. s6 `6 v4 b- o; F  \, c5 j/ t3 m8.1 Introduction to assembly and exit of virions from cells.
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8.2 Nucleocapsid assembly.* o+ h' u  X6 L# b" q
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8.3 Formation of virion membranes.. m: P* r. N3 a6 C

6 M1 d" J, K2 g, n, {$ j+ [  M! u8.4 Virion exit from the infected cell.8 W* T1 k; v- }9 t
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9 Outcomes of infection for the host.
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9.1 Introduction to outcomes of infection for the host.; B( ]3 q1 I6 L- Z4 n0 \
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9.2 Factors affecting outcomes of infection.
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9.3 Non-productive infections.
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/ a% n/ O$ w' n2 Q1 W5 @8 @9.4 Productive infections.
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' Q+ ?- T9 L! A$ l7 \10 Classification and nomenclature of viruses.
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0 R7 V9 d0 n7 K0 f( x10.1 History of virus classification and nomenclature.
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10.2 Modern virus classification and nomenclature.) D+ h) a5 J4 G# \2 {

; m1 T$ }  O/ v; [! L+ `+ s10.3 Baltimore classification of viruses.
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8 ~  w! |% A  ?  u/ e: _11 Herpesviruses (and other dsDNA viruses).
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% j+ m8 r# Y: {. d! Q11.1 Introduction to herpesviruses.
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7 T2 e. Z9 n- \: z11.2 The human herpesviruses.
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1 s7 R; T  q' s- \  o11.3 The herpesvirus virion.
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11.4 HSV-1 genome organization.
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' P5 a$ Z& F: R+ G- Z11.5 HSV-1 replication./ N. \% Q  E" l( D9 r' ]
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11.6 Latent herpesvirus infection.9 G3 O% i, V* R, X$ i+ }
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11.7 Other dsDNA viruses.
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+ Q* V. m- T& t$ t; L/ K+ I12 Parvoviruses (and other ssDNA viruses).+ l$ F/ b  i- S5 d! _" `. y

: ]; R7 E7 g" h12.1 Introduction to parvoviruses.. R% i3 V! W, o$ w. s( U% ^! m

; Z7 o3 {% c" _4 v+ T5 B; V' L12.2 Examples of parvoviruses.
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12.3 Parvovirus virion.# Y; o2 S7 e* u/ _1 `( P$ g
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12.4 Parvovirus replication.
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1 J( h: D3 i! W& `0 ^12.5 Other ssDNA viruses.
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/ `; \; K# n) E. a( c13 Reoviruses (and other dsRNA viruses).
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' L( S/ {0 C) h4 ^7 U13.1 Introduction to reoviruses.  k( Q8 E" W. K
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13.2 Rotavirus virion.
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: X8 k; g/ w: q13.3 Rotavirus replication.
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13.4 Other dsRNA viruses.
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14 Picornaviruses (and other plus-strand RNA viruses)." X& b; J$ `  }" u& J/ b* b
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14.1 Introduction to picornaviruses.
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14.2 Some important picornaviruses.
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, y$ |3 @0 F. K7 O1 Z+ Z+ }14.3 The picornavirus virion./ J9 I# Z1 w. g9 k+ t4 j6 D

, a8 t6 e# g" C% u7 _& q5 g14.4 Picornavirus replication.3 x' A/ K$ \8 }- Q$ |# @4 Q
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14.5 Picornavirus recombination.+ U1 M6 E5 B2 w: B0 W- B
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14.6 Picornavirus experimental systems5 r7 V/ j- f8 Z& f4 A: G. N

) W# G; [0 N6 b14.7 Other plus-strand RNA viruses.3 ^7 x' a. w% J4 N# |1 r& n
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15 Rhabdoviruses (and other minus-strand RNA viruses).
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15.1 Introduction to rhabdoviruses.0 |$ L  R* p( ]1 A8 R" g- f& l

! R7 y) D1 ]4 m" b. s; ~15.2 Some important rhabdoviruses.
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5 d; R+ K. e) k+ i15.3 The rhabdovirus virion and genome organization.
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$ n& k- G1 L/ j9 n15.4 Rhabdovirus replication.7 Y5 }- U+ i! Y. i+ ?- w4 c" s0 \
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15.5 Other minus-strand RNA viruses.
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15.6 Viruses with ambisense genomes.
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) W" f8 x% N; v15.7 Reverse genetics.
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16 Retroviruses.7 R8 b7 D# o) A( A8 m/ c" w
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16.1 Introduction to retroviruses./ }7 r, o2 k  b5 Z, {
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16.2 Retrovirus virion.
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16.3 Retrovirus replication.
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16.4 Examples of retroviruses.& H2 l7 i& @- A* q6 Z3 B
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16.5 Retroviruses as gene vectors.
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# M% y& h/ t& z0 T* O; A16.6 Endogenous retroviruses.- x. D( N3 L0 D: I: y$ ^

( R& H: k  J5 R, E* X% \" ~: b17 Human immunodeficiency viruses./ c) x+ `: W! F& @5 _  @

; T( H8 \3 t* c17.1 Introduction to HIV.% m7 y' S( v7 |5 d

+ n1 b/ T6 H, i, j0 u  x17.2 HIV virion.
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# I# O6 J% B# F# t2 o  n, `. D0 Q& m5 C8 X17.3 HIV genome.
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8 y$ _$ [' u9 L17.4 HIV-1 replication.
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17.5 HIV-1 variability.4 E. x1 N4 w4 u: G$ d; a/ t4 i- G

8 y( |. X0 |: w7 O8 C# H) ]3 G17.6 Progression of HIV infection.3 u9 |# _, K( W+ o. m5 @
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17.7 Prevention of HIV transmission.! g1 z3 x9 L5 B7 v. x: {; Q8 x( |& Q4 h

  m5 l8 b: _, a- V1 N18 Hepadnaviruses (and other reverse-transcribing DNA viruses).8 ~- z& o* _/ I; r. V
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18.1 Introduction to hepadnaviruses.5 ^9 A! E8 y7 G$ ?! l

9 @. z, @) L) Y7 {8 `18.2 Importance of HBV.1 C% @7 t1 a& E  J

: |* ^* b" p! J: n4 w8 X1 G18.3 HBV virion.
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' L, |& z$ C5 K, p# ~" c9 K18.4 Non-infectious particles.
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18.5 Soluble virus protein.# L# {( I8 j5 w- W6 V6 E& v

* U  F7 E6 Y7 m8 K' l7 N( m18.6 HBV genome.- R' ?) c3 [' W" ~( a  ~8 S( S  v
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18.7 HBV genetic groups.8 s% n3 x( I6 {1 Q& d# L

( g9 k6 T9 v' @1 C$ c18.8 HBV replication cycle.# N* A- d. ?& B% q' L, B8 T

2 S  d" X7 [- {2 k$ P8 A: U8 y18.9 Prevention and treatment of HBV infection.
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4 s' S7 N% k3 A18.10 Other reverse-transcribing DNA viruses.  Z2 |* @  @8 I1 w$ Z2 P* e
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19 Bacterial viruses.; {+ E4 C3 M. H0 i' {3 E# b

4 E1 h' Y" e( L  b: z19.1 Introduction to bacterial viruses (bacteriophages.
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5 ]+ b9 {% V4 h% a6 u- ^RNA PHAGES.
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19.2 Single-stranded RNA phages.
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$ C: i8 z0 T, V' R+ O19.3 Double-stranded RNA phages.
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DNA PHAGES.& X( T( Q2 ]4 F- r: V: ]$ @; u

3 Q. F) h' o* u* [19.4 Single-stranded DNA phages.2 o1 W! d1 _5 M6 j' |9 q
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19.5 Double-stranded DNA phages.
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20 Origins and evolution of viruses.* E$ t; _3 z3 N$ N( y
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21.1 Introduction to origins and evolution of viruses.
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7 @" q4 A+ ]- o4 R20.2 Origins of viruses.
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20.3 Evolution of viruses., v4 {0 U0 f! n0 _3 p+ y

/ [8 z: K8 M- u5 r- i8 X21 Emerging viruses.( v( e. v8 ~  Y% D; H3 p* D5 l- i0 V

0 `) F  s& U' c" F0 ~21.1 Introduction to emerging viruses& h: t1 s4 Y, x& ]. n2 @0 k0 n7 }& K
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21.2 Viruses in new host species
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$ b) f. i  v  v5 w- U1 m+ K21.3 Viruses in new areas
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# J3 s$ N3 v/ U7 H. W7 n+ Q21.4 Viruses in new host species and in new areas6 C6 [5 r# {3 d3 k1 ~

! ?9 c$ N# y2 }( L9 E21.5 New viruses; ^% i  z2 }; K  d2 w
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21.6 Recently discovered virus  y! M9 E/ C% e7 Q; m
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21.7 Re-emerging viruses
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+ L! k& [" }) l3 u! ?21.8 Virus surveillance
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' u  t" U" @1 p- L21.9 Dealing with outbreaks/ P; }. E3 f: o" I0 Q

% O$ h+ k  M- z2 v7 l! z22 Viruses and cancer
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22.1 Introduction to viruses and cancer: X$ q! L8 p; w- F  N7 J: d/ Z
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22.2 Papillomavirus-linked cancers
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) g. J: L. A" J4 f5 k) i22.3 Polyomavirus-linked cancers* b) B( o  B* q/ T+ O$ b* [* N. J( ]

: @1 R+ S- x' b3 y9 Y22.4 Epstein-Barr virus-linked cancers0 t; Y( t# i1 r4 h
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22.5 Kaposi’s sarcoma
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22.6 Adult T cell leukaemia
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22.7 Hepatocellular carcinoma  H9 @9 d0 C& V3 D, p

4 n5 A/ |3 E0 W3 [/ S! D22.8 Virus-associated cancers in animals! q$ [1 [' ~- |* O1 ?% E5 f7 Y

) |- P& P+ Q/ U4 x. g22.9 Cell lines derived from virus-associated cancers.$ x( ^. v  h" y" D' C
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22.10 How do viruses cause cancer?% ^4 H& T; ^5 g; Y* Q. V
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22.11 Prevention of virus-induced cancers.
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. B! v5 `1 m1 t* i+ L8 N, l# u/ w3 J23 Survival of infectivity.
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7 d) Q$ B( G6 J  m8 |$ n23.1 Preservation of virus infectivity.
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23.2 Destruction of virus infectivity./ K' z; N1 U3 }+ ~$ c

4 Q# n  V1 O7 r1 {- z' g23.3 Inactivation targets in virions.
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23.4 Inactivation kinetics.
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4 t: c, J. y5 r" x8 j23.5 Agents that inactivate virus infectivity.
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24 Virus vaccines.
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24.1 Introduction to virus vaccines.
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0 C0 H1 ~$ |3 W24.2 Live attenuated virus vaccines.( m7 j" l9 t- V7 H

# u, F' a1 q2 @24.3 Inactivated virus vaccines.
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; E6 h& I: s- M! |* D24.4 Virion subunit vaccines.! }) k) j: i' I% e
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24.5 Live recombinant virus vaccines.
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24.6 Mass production of viruses for vaccines.
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9 v1 d! _  L- ^6 e! O  K$ @: m24.7 Virus-like particles.
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2 ]; _; v  K) e, `24.8 Synthetic peptide vaccines.  m, v# ]) B0 S( R; N, h0 T
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24.9 DNA vaccines.( x: l( I7 s) c1 u3 s* M" {+ X/ p

' q. _& J( J( b( N  m" Z4 o24.10 Storage and transport of vaccines.4 i+ p! c9 H8 I1 V4 |+ X% d* @9 b
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25 Anti-viral drugs.
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# O! D2 p! _/ g25.1 Introduction to anti-viral drugs.! p" W3 w0 j! D" o  A+ ~5 l

; e& ^) j  }# _( E+ r1 {! l. @25.2 Development of anti-viral drugs.# f7 y& c0 j0 Y. C

, X1 n; G1 h0 R4 S" i25.3 Examples of anti-viral drugs.
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! ~7 ~5 d* {1 |' A3 A25.4 Drug resistance.+ m8 J5 d: q! C% r; Y6 Z* Z
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25.5 Anti-viral drug research.
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! D# j1 ?6 f5 b3 J26 Prions." H) ]  y# H$ A/ e" H, L/ S
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26.1 Introduction to prions.
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4 R' _1 T0 P2 v& W26.2 Transmissible spongiform encephalopathies.
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6 D7 J; w( b) g( u+ r0 v( j26.3 The nature of prions.5 Y% s/ W. x7 d0 W6 b1 [

' E# R- [" H; ~  }, s2 r26.4 Prion diseases.% l, v  m' ?/ x& ~7 F! L1 q
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26.5 Prion strains.5 c! A2 a6 Y( t# @+ W$ o; G
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26.6 Prion transmission.) I9 h( P( b, a0 O6 M

/ X& k. h/ t8 \6 `' r- d0 r1 |26.7 The protein-only hypothesis., s* Z$ [" _  L
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Learning outcomes.
5 M( G* {2 |6 m( j( B5 g7 T5 c; G# \$ p* G
Sources of further information.! X( Y0 M/ k, C9 a2 R

8 G1 f0 s% v: I; \' ?: P, b+ ]Virologists' vocabulary.% ~! F* L9 f' [) y/ S6 K
. y( H' K  }$ _& f; @* K
Index.

subenjinwo

好书！

yangpan521

回复 dahui 的帖子) ~3 L* ?$ Q7 x- O5 _' |
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看看

chleiwu

学习

tait1

kankan

zorro

3qqq

zzc2211

好书，谢谢楼主分享

白色的风

谢谢楼主

susannajoke

好东西

stem_cell007

kankan