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本帖最后由 细胞海洋 于 2012-3-26 13:34 编辑 / j4 F( |6 }$ @' s7 ?2 y
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Cellular DNA is subjected to continual attack, both by reactive species inside' l5 I# \+ b. V8 ?
cells and by environmental agents. Toxic and mutagenic consequences are
. T$ F% `" j0 T6 e1 Mminimized by distinct pathways of repair, and 130 known human DNA repair, D1 A- s2 x8 X# M
genes are described here. Notable features presently include four enzymes that: A1 q& r3 F% m' W% C4 }
can remove uracil from DNA, seven recombination genes related to RAD51, and
6 |, k9 `1 u! g2 M5 Xmany recently discovered DNA polymerases that bypass damage, but only one1 L" M3 y( z* J, o3 z6 p
system to remove the main DNA lesions induced by ultraviolet light. More
9 e& Z7 ?6 F w7 Shuman DNA repair genes will be found by comparison with model organisms0 {; l% H- E/ v, c
and as common folds in three-dimensional protein structures are determined.' X3 G& F- O+ A4 ^2 k
Modulation of DNA repair should lead to clinical applications including im-$ U. E$ f) u3 o+ Q; }! S6 R0 v
provement of radiotherapy and treatment with anticancer drugs and an ad-
. t' {' N6 u6 A% P- tvanced understanding of the cellular aging process.1 j: x2 U- C$ A8 _! G
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发表于 2012-3-26 11:00
