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本帖最后由 细胞海洋 于 2012-3-26 13:34 编辑
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4 e1 J+ A0 v% ]7 dCellular DNA is subjected to continual attack, both by reactive species inside
6 q6 Y( z( Z% D/ B3 a0 y7 Q% Ucells and by environmental agents. Toxic and mutagenic consequences are& \/ n3 F% a. O" ? R% @
minimized by distinct pathways of repair, and 130 known human DNA repair
$ o" q9 y4 T6 N4 @: w2 Ogenes are described here. Notable features presently include four enzymes that2 q# J) Q" E* S$ x
can remove uracil from DNA, seven recombination genes related to RAD51, and% F$ }- H1 B* M* y( z+ m
many recently discovered DNA polymerases that bypass damage, but only one
+ w" o6 X( S' o0 P( {% P' tsystem to remove the main DNA lesions induced by ultraviolet light. More0 m8 h6 i7 S1 i k" G
human DNA repair genes will be found by comparison with model organisms! O/ h2 w* M0 O) F6 ]6 O: U
and as common folds in three-dimensional protein structures are determined.2 f0 x( d! {/ c0 f* s# p7 w( w( u
Modulation of DNA repair should lead to clinical applications including im-$ I9 l+ s, E1 [8 B u4 E) h
provement of radiotherapy and treatment with anticancer drugs and an ad-
9 d. `" u: G2 H' yvanced understanding of the cellular aging process., l0 U* f3 Y( I. S/ C
t0 e! q$ }+ ^# S/ d[hide][/hide] |
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发表于 2012-3-26 11:00
