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本帖最后由 细胞海洋 于 2012-3-26 13:34 编辑
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Cellular DNA is subjected to continual attack, both by reactive species inside
+ P3 K& v' Q" M b$ e7 I$ acells and by environmental agents. Toxic and mutagenic consequences are! c! Z1 \+ W" p5 t! {, b) q
minimized by distinct pathways of repair, and 130 known human DNA repair, M* ~. C5 M, D
genes are described here. Notable features presently include four enzymes that
- {/ k7 W/ w" L, J( i* g& D" h* F8 jcan remove uracil from DNA, seven recombination genes related to RAD51, and
4 F5 B: ]& k" R* |5 |many recently discovered DNA polymerases that bypass damage, but only one
# q* `! O( C9 |9 Osystem to remove the main DNA lesions induced by ultraviolet light. More8 d, D% m0 w' u n8 r
human DNA repair genes will be found by comparison with model organisms
2 i, A3 `1 Y& I9 v4 Tand as common folds in three-dimensional protein structures are determined. v& n3 B; W- \8 K" h: W) o
Modulation of DNA repair should lead to clinical applications including im-! \2 M, D" @2 }0 ~
provement of radiotherapy and treatment with anticancer drugs and an ad-
: H5 G8 ? q B% Uvanced understanding of the cellular aging process.3 n0 w8 {8 W6 Y
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发表于 2012-3-26 11:00
