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' d: F; M0 D& V- f+ p4 @& Z# pVolume 149, Issue 3- F8 y3 z! b% z" Z6 H: c7 y
On the cover: The combined activity of neurons in the brain generates
+ T' l- Y6 K) z t& \oscillatory rhythms, or “brain waves,” that can be detected by
7 j( d( ^# C `& @! N5 velectroencephalographic recordings. Verret et al. (pp.708–721) found that these ! r" l$ `5 J0 W7 K5 t7 w9 z& m
brain waves, which are represented on the cover by an undulating pattern, are % I- }* a9 A5 o1 `8 b
altered in mouse model of Alzheimer's disease (AD), and the changes are linked $ E& r6 \- p4 Q4 f6 m ?
to reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring
, ]& V9 m5 _& {$ ?+ YNav1.1 levels specifically in inhibitory interneurons improves oscillatory 9 w) Z% w0 [5 X0 P- }, d' Q
rhythms and memory in AD mice, offering a new therapeutic approach for % p, U- Z3 S% O/ w* u- K
potentially treating cognitive disorders. The image was created by Arantxa
4 K3 }7 {) a. Y& p' gEsteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop ( n# w w, _5 V5 n
(electronic recreation).' t4 k2 o$ K+ A7 x5 |
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