《细胞》[Cell]12年4月27日出版pdf全文

nero1981

; C) w8 d" y3 B1 R  h7 B- H2 zVolume 149, Issue 3
( P7 a/ L/ U1 T# [$ U! xOn the cover: The combined activity of neurons in the brain generates
) o" u/ [* ]& x! w5 soscillatory rhythms, or “brain waves,” that can be detected by
: I! a. @- n6 I) Ielectroencephalographic recordings. Verret et al. (pp.708–721) found that these - p7 F& a9 p8 M2 x
brain waves, which are represented on the cover by an undulating pattern, are 7 e, L% w8 U8 o+ E# f
altered in mouse model of Alzheimer's disease (AD), and the changes are linked
& y0 v% _: l0 w" tto reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring
+ ~7 a! n8 w* w$ @Nav1.1 levels specifically in inhibitory interneurons improves oscillatory
) R; u! ?1 L) d  J: y1 {! k( i5 i4 {7 xrhythms and memory in AD mice, offering a new therapeutic approach for 0 }3 o2 V, J; X# S+ Y, c! y
potentially treating cognitive disorders. The image was created by Arantxa ' T5 x" j2 ~# G9 W; n2 b. H
Esteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop - b/ B* o- y' D+ [2 }$ d
(electronic recreation).
2 C' r/ E1 o: {9 p- O[hide][/hide]

menghy

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xiaoheilong

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不倒翁

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eley

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cytobiology

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zorro

回复 cytobiology 的帖子2 ~; E- K4 \8 a& C

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markllq

谢谢
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191225092

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