PDF电子书：Cancer Epigenetics - Methods and Protocols （2012）

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9 H6 `4 \$ P3 G: k' C[hide][/hide]7 n7 z2 G7 c8 H. \3 }0 o7 |1 ?
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ISSN 1064-3745 e-ISSN 1940-6029
9 @3 c) Z+ V! m5 @ISBN 978-1-61779-611-1 e-ISBN 978-1-61779-612-8  [4 E. J! F  N' A
DOI 10.1007/978-1-61779-612-8/ \0 ?2 d7 d# w# V( X. H
Springer New York Dordrecht Heidelberg London7 T$ `7 d0 |) i- N
Library of Congress Control Number: 2012931559
  ~8 [+ M# n5 A+ i& m7 r© Springer Science+Business Media, LLC 2012( _. j% C6 M6 H7 @* H% K
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Contents
+ ]7 u7 S! O& z0 m% ?. ?Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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, ^7 H1 x# i1 hContributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ; X  |) @4 d# q, b2 L! n; u
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PART I   EARLY EPIGENETIC EVENTS IN CANCER4 n4 M7 h1 \* k8 t, _2 \7 p' R
1   Epigenetic Markers of Early Tumor Development . . . . . . . . . . . . . . . . . . . . . .      
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5 u2 v" K  z2 l/ h6 vRamona G. Dumitrescu6 @" N( v0 j3 [+ I
2   Epigenetics of Solid Cancer Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . + F% V" E( m: y9 |/ w$ L$ V
. .       15
9 L3 C* M" {! N3 @( g* E4 VAlok Mishra and Mukesh Verma
9 Z: s/ A  ]7 n. v, g: l6 D% _7 P+ @3 aPART II    CANCER SPECIFIC TYPE EPIGENETIC CHANGES
+ ?/ W6 O' }9 h& m2 h3   DNA Methylation and Histone Modifications in Breast Cancer . . . . . . . . . . . .       35
0 D3 g3 Z9 n' pRamona G. Dumitrescu: M$ x: k6 t5 I0 e+ }
4  DNA Methylation Changes in Prostate Cancer . . . . . . . . . . . . . . . . . . . . . . . .      " r5 r8 S* E3 O: s* M8 N# B
47
- W4 R! m0 W9 b" `Wolfgang Goering, Michael Kloth, and Wolfgang A. Schulz
* P: `- i0 y9 m. m6 R% Z4 m7 X5   DNA Methylation in Promoter Region as Biomarkers1 }1 x/ T: _  b* ]
in Prostate Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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1 S/ U7 [. X. b; \9 aMihi Yang and Jong Y. Park
6 Y. y6 ]7 I* x; G' }- l6   Epigenetics of Bladder Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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. G  g4 s, d/ C+ |  ^/ gWun-Jae Kim and Yong-June Kim. B  |' o# y+ @9 a
7  Epigenetics in Myeloid Malignancies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Stefan Deneberg% n) O% k" |' w; j* f; I/ g% q( K
8   The Epigenetics of Brain Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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3 b, h$ x. |# C9 NAdrian M. Dubuc, Stephen Mack, Alexander Unterberger, Paul A. Northcott, and Michael D. Taylor$ j- z  q9 c- @- ]" o! d' P
9  DNA Methylation Changes in Cervical Cancers . . . . . . . . . . . . . . . . . . . . . . .    155
8 p0 s6 ?9 F$ l2 I3 E7 H% \Qiang Lu, Dehua Ma, and Shuping Zhao, @6 l! Y3 @8 J. D5 |# \; [
10   Epigenetics of Colon Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
5 W8 u" z$ c7 X9 e. . . . .     177" c) P0 s7 C- t4 Q; t+ k2 }
Sharad Khare and Mukesh Verma9 H+ d9 z& e7 o" S( _
11  Promoter Methylation in Head and Neck Tumorigenesis. . . . . . . . . . . . . . . . .    187
  ?% P7 k2 N+ ?. Q7 MJosena K. Stephen, Kang Mei Chen, Shaleta Havard, Glynis Harris, and Maria J. Worsham
: B% H* o% _7 T) B. p12   Epigenome and DNA Methylation in Oral/ ]" s3 H( [$ P0 D4 m
Squamous Cell Carcinoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 R$ X6 V% _% {4 K
.    207
5 f1 U0 v6 `& l) s; ?  [9 YMario Pérez-Sayáns García and Abel García-García
" T$ ?* r' }8 M/ EMario Pérez-Sayáns García and Abel García-García9 L8 w4 l$ G' [& F, T
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9 ^# C  a3 N6 mviii           Contents/ }4 X6 t$ x1 I; f
13   Clinical Implications of Epigenetic Alterations in Human' n7 p8 E1 b0 W7 R. m$ \  C# ^
Thoracic Malignancies: Epigenetic Alterations in Lung Cancer . . . . . . . . . . . .     221
3 V8 h  P) s" g$ y* o: @Keiko Shinjo and Yutaka Kondo
; W+ N% H9 {( o1 a5 s1 y9 I14   The Role of MicroRNAs in the Management of Liver Cancer . . . . . . . . . . . . .     2412 O. ]/ F% f; N7 U" \
Krishna K. Banaudha and Mukesh Verma, u" c& g8 ~4 l( ~- B1 V2 O  `
15   Epigenetics in Ovarian Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . % d; S7 d  O5 c+ s$ E. v: N9 k- }9 b
. . . .     253
" o9 U1 \; `. {L.M.S. Seeber and P.J. van Diest% O- i+ ^' z# p( Z4 E2 p

& n& {1 ]0 H! v' E2 c+ VPART III   METHODS AND TECHNOLOGIES USED FOR EPIGENETIC CHANGES’ DETECTION* m4 p! [2 h5 o' C
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16   DNA Methylation in Pancreatic Cancer: Protocols0 ]; I& q# H5 k) R! K  f, m
for the Isolation of DNA and Bisulfite Modification . . . . . . . . . . . . . . . . . . . .     273
" B# N- v5 ^, Y3 JKatja Biewusch, Marie Heyne, Robert Grützmann, and Christian Pilarsky
+ h% g# U6 ~2 o8 N/ I17   Detection and Analysis of DNA Methylation by Pyrosequencing . . . . . . . . . . .     281, G/ O) t/ p- C- M$ p2 y! N
Hilary A.A. Colyer, Richard N. Armstrong, Daniel J. Sharpe, and Ken I. Mills) y! z7 V' {6 C
18   Screening for miRNA Expression Changes Using Quantitative
5 X) ~$ q! P( Q1 S8 o% r( qPCR (Q-PCR) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 [& B5 b6 l# o  ^+ D/ ^
. . . .    293  H3 }5 j/ d! k) [
Richard N. Armstrong, Hilary A.A. Colyer, and Ken I. Mills
" o' @; D4 W$ m19   Genome-Wide Methylation Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Alexander Unterberger, Adrian M. Dubuc, and Michael D. Taylor
# P5 p3 ]! y% _* p& [7 Y: C0 b' Y20  Microarray for Epigenetic Changes: Gene Expression Arrays . . . . . . . . . . . . . .   319
/ S9 Z) L8 ]. v  T, M: EHilary A.A. Colyer, Richard N. Armstrong, and Ken I. Mills
/ |8 s$ k6 j, ^6 v- Q) U2 W21  Detecting DNA Methylation Using the Methylated CpG9 y5 J$ z# O- k' f3 ^- o& G
Island Amplification and Microarray Technique. . . . . . . . . . . . . . . . . . . . . . . .     ' e+ d; ?- @( U$ d# x
329( i% E+ n& u4 S  S. t6 D8 P( ^
Hilary A.A. Colyer, Margaret Dellett, and Ken I. Mills
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: U& _4 s0 A. l4 A0 w- @, hPART IV  FACTORS THAT INFLUENCE THE EPIGENETIC CHANGES IN CANCER% H6 f: c$ s/ _& m& Q/ y% K
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22   Nutrigenomics: Implications for Breast and Colon Cancer Prevention . . . . . . .     3431 |9 `! U. z% w
Gabriela Riscuta and Ramona G. Dumitrescu* D8 ^& o* t: h7 K/ |# i/ y# d
23   Dietary and Lifestyle Factors of DNA Methylation . . . . . . . . . . . . . . . . . . . . .     
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Unhee Lim and Min-Ae Song6 H0 k" u2 }5 `3 @/ ?/ t
24   Diet, Epigenetics, and Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [* b# M. o4 F2 ]1 Y5 [
. . . . .     377, S  |9 C+ W; Q9 U
L. Joseph Su
* P/ c8 t. O4 b8 U' Q1 d7 A25   Role of Epigenetics in Cancer Health Disparities . . . . . . . . . . . . . . . . . . . . . . .
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Sulma I. Mohammed, Sanya Springfield, and Rina Das. l$ Y) N) q+ N8 E' _
26   Multifactorial Etiology of Gastric Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . 8 a& z7 M9 ^0 X& K% R" |
. .     411% }/ m* A- [$ x5 g, E
Jovanny Zabaleta+ d, U/ W* K* `  D% h

  N! O. C: Z: t* x+ V0 S/ K; n# ^Contents             ix
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; M6 J' `. e# h+ `6 D. a! z( {PART V    EPIGENETIC EPIDEMIOLOGY3 X' M9 X1 J5 n! I5 d8 d+ A+ ^
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27  Epigenetic Epidemiology for Cancer Risk: Harnessing Germline, `% y* P5 p& Z8 j' s
Epigenetic Variation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Kevin Brennan and James M. Flanagan
5 a- W8 H& b5 O3 l28   Epigenetic Biomarkers in Cancer Epidemiology. . . . . . . . . . . . . . . . . . . . . . . .    8 q6 K5 v0 q+ @$ Z
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Mukesh Verma
3 p: ~/ O  `. f5 ~( I+ Y5 I4 T* oIndex . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
# M. L1 ?4 K4 a' i7 e/ t. . . . . . . . . . . .     481
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