PDF电子书：Cancer Epigenetics - Methods and Protocols （2012）

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ISSN 1064-3745 e-ISSN 1940-6029
9 }2 e3 d7 K8 O: r2 a' LISBN 978-1-61779-611-1 e-ISBN 978-1-61779-612-8& P' U- R! Z( J; m9 a& n" j
DOI 10.1007/978-1-61779-612-8, `/ n% r2 x5 X& L) z* T8 w
Springer New York Dordrecht Heidelberg London4 h- n4 h9 w/ s8 f. f! H% K2 n. ]
Library of Congress Control Number: 2012931559
. U6 ~9 P  m8 T: n© Springer Science+Business Media, LLC 2012
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8 j* ]# i# O  U3 {+ ]% ]Contents
1 X7 q; l# }4 yPreface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . * |/ i- }' m! |( X+ K
. . . . . . . . . . . .         v
4 e1 {! f& [5 x1 d" g1 s: D9 V7 h; y) }Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
5 P" k+ B* ~3 r( r: {$ a. . . . . . . . . .        xi
$ @+ H1 `$ v. H. s; J, N2 a% N1 j) bPART I   EARLY EPIGENETIC EVENTS IN CANCER( @1 q6 V1 I2 a# }+ ^
1   Epigenetic Markers of Early Tumor Development . . . . . . . . . . . . . . . . . . . . . .      
3 C1 M3 l# m* J# u! V  3
: h; O8 K! q  `. ~2 q' ]Ramona G. Dumitrescu6 }+ E5 R' c' q+ L
2   Epigenetics of Solid Cancer Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Alok Mishra and Mukesh Verma4 n9 h5 \/ U3 G
PART II    CANCER SPECIFIC TYPE EPIGENETIC CHANGES/ l& X2 \) Q; `9 a9 j. }+ J
3   DNA Methylation and Histone Modifications in Breast Cancer . . . . . . . . . . . .       35' K6 U# c4 C( M' Q
Ramona G. Dumitrescu/ y8 o" t6 o0 e
4  DNA Methylation Changes in Prostate Cancer . . . . . . . . . . . . . . . . . . . . . . . .      
8 T$ ^" q  \, m- q" u47
2 `3 v( V. R# m$ S) h  [Wolfgang Goering, Michael Kloth, and Wolfgang A. Schulz$ K; I" j, ]/ O+ }" [+ G" T
5   DNA Methylation in Promoter Region as Biomarkers
# e# ^4 A3 P+ `: ]/ U: [9 xin Prostate Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Mihi Yang and Jong Y. Park
3 q6 B: Z3 A0 H6   Epigenetics of Bladder Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
, R& w$ B+ h" L+ d8 z$ p  A. c. . . .     111
5 z- u) Y. }: B4 ~* Z* n2 V0 E" xWun-Jae Kim and Yong-June Kim- k$ F% n' z  w. [" j) z
7  Epigenetics in Myeloid Malignancies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . : b- n* r, C. U# }; Y4 r) d- N
. .    119
6 R* J2 \! _% T  [9 h0 b9 IStefan Deneberg1 e* E6 `! p' ^9 S  |
8   The Epigenetics of Brain Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
9 X, P9 h& A2 c! z- `. .     139
7 P4 k" c0 C8 L; DAdrian M. Dubuc, Stephen Mack, Alexander Unterberger, Paul A. Northcott, and Michael D. Taylor
5 ^/ s6 D/ x+ ~1 ~( S# ^9  DNA Methylation Changes in Cervical Cancers . . . . . . . . . . . . . . . . . . . . . . .    155
1 w; ?5 E6 m3 v/ n& OQiang Lu, Dehua Ma, and Shuping Zhao
7 U3 |9 X7 y7 _/ c' Q' X: I10   Epigenetics of Colon Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ?/ [) d7 r( {' `
. . . . .     177
6 f; V' l+ p" Q" P) ESharad Khare and Mukesh Verma
/ O9 T4 b0 a# j0 F0 B11  Promoter Methylation in Head and Neck Tumorigenesis. . . . . . . . . . . . . . . . .    187
9 P7 `, b3 K$ k# l) @9 \: [( \Josena K. Stephen, Kang Mei Chen, Shaleta Havard, Glynis Harris, and Maria J. Worsham
& _4 K2 o: ~& p) y" Z. P5 v5 a12   Epigenome and DNA Methylation in Oral
( [6 E) f; s* q! m. pSquamous Cell Carcinoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
; [. I: K) e0 g6 r& }+ X$ v.    207
' n( q  r6 k2 m% UMario Pérez-Sayáns García and Abel García-García
! B6 d4 g$ k% b" dMario Pérez-Sayáns García and Abel García-García
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3 R0 o6 a9 i, \" \* m3 T0 wviii           Contents7 h. ?' K& M$ a2 g+ y2 D- k
13   Clinical Implications of Epigenetic Alterations in Human& i) ?$ Y" M/ I0 [: t, Q% c
Thoracic Malignancies: Epigenetic Alterations in Lung Cancer . . . . . . . . . . . .     221: K# s; u! v0 [/ D
Keiko Shinjo and Yutaka Kondo$ s( n/ U" X( v; Y( T$ l
14   The Role of MicroRNAs in the Management of Liver Cancer . . . . . . . . . . . . .     241
* d+ I  S, j7 b6 |% LKrishna K. Banaudha and Mukesh Verma, d/ j+ b* z/ S! M7 R4 W
15   Epigenetics in Ovarian Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
' e  F6 K- a0 f' `( U0 i* D6 L7 _. . . .     253
4 k% H5 D$ r, j  ~L.M.S. Seeber and P.J. van Diest
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PART III   METHODS AND TECHNOLOGIES USED FOR EPIGENETIC CHANGES’ DETECTION
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( c4 E3 d+ X. C* J; g) D16   DNA Methylation in Pancreatic Cancer: Protocols" d7 {3 L) R' V3 M- Z( I9 [
for the Isolation of DNA and Bisulfite Modification . . . . . . . . . . . . . . . . . . . .     2730 @: H8 Y- L- w
Katja Biewusch, Marie Heyne, Robert Grützmann, and Christian Pilarsky
" A' K. y/ W- _8 i% J, ^4 J6 e! U- j17   Detection and Analysis of DNA Methylation by Pyrosequencing . . . . . . . . . . .     2814 ^- _2 Z% d. S3 N1 z9 J; P
Hilary A.A. Colyer, Richard N. Armstrong, Daniel J. Sharpe, and Ken I. Mills0 G; ?5 i  X- [) [
18   Screening for miRNA Expression Changes Using Quantitative1 l' |6 R0 o% y) O3 K; ~' x
PCR (Q-PCR) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Q0 c% f$ A/ |3 E: H8 W
. . . .    293  h# L# T, Y5 a) L& F) ?$ `
Richard N. Armstrong, Hilary A.A. Colyer, and Ken I. Mills$ n* q# _0 T8 \6 J6 ^) H* h
19   Genome-Wide Methylation Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 O) t# M) l+ }7 _7 W0 ?
.     303
! m1 m% q, _8 r  V  PAlexander Unterberger, Adrian M. Dubuc, and Michael D. Taylor8 n% C# I% v/ E/ `) O
20  Microarray for Epigenetic Changes: Gene Expression Arrays . . . . . . . . . . . . . .   319
. s3 U0 ?7 a6 }4 [; xHilary A.A. Colyer, Richard N. Armstrong, and Ken I. Mills  Z- N  w0 h% Y; _% G' @! b
21  Detecting DNA Methylation Using the Methylated CpG
5 J; y! Z" \# s3 a% @! [4 _' rIsland Amplification and Microarray Technique. . . . . . . . . . . . . . . . . . . . . . . .     
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Hilary A.A. Colyer, Margaret Dellett, and Ken I. Mills5 J3 b- ]+ f7 B; Q1 Y7 _# f

) ?' z" P% h* t% pPART IV  FACTORS THAT INFLUENCE THE EPIGENETIC CHANGES IN CANCER
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22   Nutrigenomics: Implications for Breast and Colon Cancer Prevention . . . . . . .     343. f5 u3 Q' E# c8 r/ a) i' @
Gabriela Riscuta and Ramona G. Dumitrescu
! p" E+ G: Z8 T* K& H; ~23   Dietary and Lifestyle Factors of DNA Methylation . . . . . . . . . . . . . . . . . . . . .     
6 Y& v- W+ B  P/ v5 Y7 O! L5 ^359
# v9 p& y5 i, o6 W, qUnhee Lim and Min-Ae Song
, x8 r& [5 ~- u! [24   Diet, Epigenetics, and Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . * `/ I; ?7 V! r2 V9 H
. . . . .     3777 ?; E5 @$ u9 v
L. Joseph Su3 o' M2 |. B1 ?0 i% z8 K: C
25   Role of Epigenetics in Cancer Health Disparities . . . . . . . . . . . . . . . . . . . . . . . ! e: C: }9 \, M6 O' Z8 R
    395
  `( Y5 ~. c! g: j8 S/ R3 q5 [Sulma I. Mohammed, Sanya Springfield, and Rina Das
9 U" z  t' _9 r3 z. Y! W6 k& C9 K26   Multifactorial Etiology of Gastric Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . 8 P$ V! t* \1 o8 O
. .     411( W& o& I8 W. T/ C# m- y7 ?
Jovanny Zabaleta2 _  ^+ w! h# b+ Q
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Contents             ix  h' {  h2 Y+ w" v

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6 L* n$ V) ?: Y6 n5 _7 WPART V    EPIGENETIC EPIDEMIOLOGY" V% ?3 U  W1 V
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27  Epigenetic Epidemiology for Cancer Risk: Harnessing Germline  J" Y( R0 f$ X. t7 |
Epigenetic Variation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Kevin Brennan and James M. Flanagan. Z. r0 i9 y% Y/ J  `
28   Epigenetic Biomarkers in Cancer Epidemiology. . . . . . . . . . . . . . . . . . . . . . . .    2 a8 J9 k: y- A# F) ~
467
; l( y/ ^# _7 _! s" V1 X* Q4 xMukesh Verma; u( \: ~, b- q7 T& U1 }  y0 k
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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