《细胞》[Cell]13年3月28日出版pdf全文

nero1981

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! o9 b( g: ~' `# n. Q. e8 RVolume 153, Issue 1
- d# O1 E! A9 M% X% J6 |, h, q3 V" yOn the cover: The kind of food an organism consumes has a broad reaching
# ~+ k2 u" r, F# gimpact on its development, behavior, and lifespan. In this issue, two
( z# l. j% c% D% s# |# C6 C% k6 Q  spapers, MacNeil et al. (pp. 240–252) and Watson et al. (pp. 253–266), explore + h4 B% E7 k: P$ p1 W
the effects of diet on these life-history traits in the nematode C. 8 V: w: v  X+ |  I! F4 l& ~
elegans. Combining nutrigenomics and network analyses, they find that + u7 d7 D. m2 {' t  i( y: Y
different diets affect traits via distinct mechanisms. The response to diet is
$ D7 t3 f4 Q7 ccoupled to metabolic changes, and disruptions of some of these specific & f, e" S5 Y& T$ X. r) z3 L' u
metabolic pathways correspond to inborn errors of metabolism in humans. The
& P+ b$ ?9 s4 u  }% q/ Bcover features a “native-art-inspired abstraction” of a worm eating a bacterial
9 _2 ^9 I; Z' t+ e6 j1 rdiet and illustrates the interconnectedness between diet, nuclear gene
9 F, I  r# G2 O4 f7 j, n9 Qregulatory networks, mitochondrial networks, and their effects on life-history
0 ?2 h+ [; j1 K+ g; Gtraits such as development and brood size. Cover art by Lesley T. MacNeil.9 O& f$ V7 y' c

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