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本帖最后由 细胞海洋 于 2013-3-29 18:59 编辑
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: |1 C- E6 C: o4 LVolume 153, Issue 18 I$ U8 m/ q) \: C2 R/ C
On the cover: The kind of food an organism consumes has a broad reaching
, f8 k0 ] _: k. z1 ~impact on its development, behavior, and lifespan. In this issue, two
& a7 W& R# w7 o4 `% e" s1 W7 qpapers, MacNeil et al. (pp. 240–252) and Watson et al. (pp. 253–266), explore
6 A* r$ d z# n* D8 [the effects of diet on these life-history traits in the nematode C. . r4 U' Z2 F+ M) x L! K% A
elegans. Combining nutrigenomics and network analyses, they find that
" ]/ |0 [' `% k7 q/ n* q2 ndifferent diets affect traits via distinct mechanisms. The response to diet is ! }8 `5 ~" D; A2 W, Y+ b4 u
coupled to metabolic changes, and disruptions of some of these specific
/ \- d1 F9 b7 D/ Lmetabolic pathways correspond to inborn errors of metabolism in humans. The
9 n$ I; V {2 g# k+ z6 ]2 d Kcover features a “native-art-inspired abstraction” of a worm eating a bacterial 6 c+ N' H6 S6 Q( u! ~, i
diet and illustrates the interconnectedness between diet, nuclear gene
. M7 d- U9 U2 Y; t; |, mregulatory networks, mitochondrial networks, and their effects on life-history . P4 Z1 [% H+ g( v5 B) D
traits such as development and brood size. Cover art by Lesley T. MacNeil.
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发表于 2013-3-29 13:31
发表于 2013-3-29 23:38
