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$ Z7 f* Z% {0 ]" B. L/ TVolume 25, Issue 3On the cover: ! n3 Y. n2 B: s+ M
Epidermal growth factor (EGF) induces fast and efficient mitotic progression,
9 G( g% @) a6 y: D" Y: tparticularly in cancer cells, by accelerating centrosome separation. Thus, a ! M: }! Q V# l- F8 I( W
HeLa cell treated with EGF proceeds faster through mitosis (left path) than a : N& w+ ~* b; Q9 k4 l
cell left untreated (right path), as visualized by confocal microscopy.
2 }3 b' v3 b" \# o9 m4 RH2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear 1 {* A" h) _! c4 v
envelope. For more information on the effect of EGF on centrosome separation and & X$ y; E; W. z L2 b
mitotic progress, and on how this may relate to cancer therapeutic strategies,
' \8 c: W+ D9 Y% K% jsee Mardin et al., pp. 229–240.% m8 V ?" `' Q( ]8 u
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发表于 2013-5-21 22:33
发表于 2013-5-22 10:29
