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Volume 25, Issue 3On the cover:
7 n8 M6 a8 y0 R. N3 y5 n- F( w) CEpidermal growth factor (EGF) induces fast and efficient mitotic progression, G: i5 m' A6 f V
particularly in cancer cells, by accelerating centrosome separation. Thus, a
5 b) l- [, v. T1 p# n* `HeLa cell treated with EGF proceeds faster through mitosis (left path) than a
2 I5 [, O9 Y/ ?5 w% ecell left untreated (right path), as visualized by confocal microscopy.
7 ^$ l4 N* M1 U: A+ C7 X, ~& wH2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear
0 d& w+ |7 `7 k4 s. ~* fenvelope. For more information on the effect of EGF on centrosome separation and
, e! {# Q6 T# n2 p* Fmitotic progress, and on how this may relate to cancer therapeutic strategies, 2 z& i8 E' h2 R$ b" \$ H. _
see Mardin et al., pp. 229–240.- V' v6 L& b H& z# A
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发表于 2013-5-21 22:33
发表于 2013-5-22 10:29
