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Volume 25, Issue 3On the cover:
$ a2 W1 U7 p: O/ _7 ]Epidermal growth factor (EGF) induces fast and efficient mitotic progression, 7 |& V% \& Q# L0 a+ O$ b
particularly in cancer cells, by accelerating centrosome separation. Thus, a
+ Q3 C, y+ t4 N0 p; w" z: hHeLa cell treated with EGF proceeds faster through mitosis (left path) than a
' z1 U- r9 I6 m8 L5 T4 y6 v+ R& E ucell left untreated (right path), as visualized by confocal microscopy.
' @# g5 m9 a1 \( T' C9 LH2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear 1 t1 Y- ^6 r- e3 F' Z9 x
envelope. For more information on the effect of EGF on centrosome separation and ) K! L5 r/ h! m, ]% P2 X
mitotic progress, and on how this may relate to cancer therapeutic strategies, ' \5 b' L1 f5 G3 ^2 P' J& _ R1 e* E+ P
see Mardin et al., pp. 229–240." x$ q! E0 x/ K0 O
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发表于 2013-5-21 22:33
发表于 2013-5-22 10:29
