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6 @' V- Z6 P# q2 pVolume 25, Issue 3On the cover:
& I' m2 M8 b% }# Q! Q' GEpidermal growth factor (EGF) induces fast and efficient mitotic progression, ( j" M3 \6 C2 h P: {% `& H2 S z
particularly in cancer cells, by accelerating centrosome separation. Thus, a - @" K, U, h5 E! C5 {9 ~4 K
HeLa cell treated with EGF proceeds faster through mitosis (left path) than a
' y- V$ U) s5 \8 _' hcell left untreated (right path), as visualized by confocal microscopy. 1 \% s; v/ d) k B0 R$ Q' g% g4 F
H2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear
4 f' t0 ]9 z- z- `3 N1 b4 aenvelope. For more information on the effect of EGF on centrosome separation and ; R! `& {, l4 m. V3 s
mitotic progress, and on how this may relate to cancer therapeutic strategies, # {5 x4 f7 u, m' a; A. V
see Mardin et al., pp. 229–240.
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发表于 2013-5-21 22:33
发表于 2013-5-22 10:29
