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2 i' g' i+ q) F/ E* qVolume 25, Issue 3On the cover: ' q W/ v* B' [) }( N
Epidermal growth factor (EGF) induces fast and efficient mitotic progression,
" h5 g( H+ U+ g9 yparticularly in cancer cells, by accelerating centrosome separation. Thus, a
0 R& T. v; z! aHeLa cell treated with EGF proceeds faster through mitosis (left path) than a $ e! t v Y: C% w5 _
cell left untreated (right path), as visualized by confocal microscopy. ' x9 Z9 z- ?/ a/ a1 ^# M
H2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear
3 Z4 V* s. l! v$ w% V, Y' v# venvelope. For more information on the effect of EGF on centrosome separation and $ `, |% i' \* c! W9 ^( S$ i
mitotic progress, and on how this may relate to cancer therapeutic strategies,
% i8 g2 P5 f* j" Q9 k8 Gsee Mardin et al., pp. 229–240.9 E* f5 Y4 S' a5 c& D
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发表于 2013-5-21 22:33
发表于 2013-5-22 10:29
