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Volume 25, Issue 3On the cover:
6 U8 h+ }- V5 W* [) `Epidermal growth factor (EGF) induces fast and efficient mitotic progression, ' o) ?+ Z( M+ F" h& P: y- X8 e
particularly in cancer cells, by accelerating centrosome separation. Thus, a
, ^0 U2 X& @8 C7 F; N# P' pHeLa cell treated with EGF proceeds faster through mitosis (left path) than a 7 b. i! z' z: t
cell left untreated (right path), as visualized by confocal microscopy. $ H, C8 L' L; @* j
H2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear
( c2 n3 {7 x# o2 g/ A9 ]! ~envelope. For more information on the effect of EGF on centrosome separation and
7 U* j5 Z. ~: x; b$ Ymitotic progress, and on how this may relate to cancer therapeutic strategies, 5 x2 \& l) g) l% U! y! Y
see Mardin et al., pp. 229–240.) o) {' o$ C+ t
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