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Volume 25, Issue 3On the cover: + ]# S5 \0 z5 W. x+ Y
Epidermal growth factor (EGF) induces fast and efficient mitotic progression, $ o: a$ ?- o3 @5 R
particularly in cancer cells, by accelerating centrosome separation. Thus, a
: n& s" k$ r/ l! ]4 a0 THeLa cell treated with EGF proceeds faster through mitosis (left path) than a 1 L9 U5 U [9 G8 e
cell left untreated (right path), as visualized by confocal microscopy.
/ A9 r, V/ {+ a. r4 ^( fH2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear 9 \# }* f4 p5 v
envelope. For more information on the effect of EGF on centrosome separation and
! e# w5 a& m+ r' G, z' I* {# Fmitotic progress, and on how this may relate to cancer therapeutic strategies,
& S( s8 B% `( E# csee Mardin et al., pp. 229–240.
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发表于 2013-5-21 22:33
发表于 2013-5-22 10:29
