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Volume 25, Issue 3On the cover: 8 O$ W' `3 [/ P# y
Epidermal growth factor (EGF) induces fast and efficient mitotic progression,
5 o- s, s" F7 B& v5 K" r$ g/ L' Nparticularly in cancer cells, by accelerating centrosome separation. Thus, a
Y; |/ v5 Q" mHeLa cell treated with EGF proceeds faster through mitosis (left path) than a " @+ q6 J1 n% z6 i! | y( O) S
cell left untreated (right path), as visualized by confocal microscopy. " U5 C3 {& o: }& q/ [
H2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear
5 d5 a- A0 |. Q: w! a+ f( fenvelope. For more information on the effect of EGF on centrosome separation and % F# r8 m' x/ \) h
mitotic progress, and on how this may relate to cancer therapeutic strategies, + R2 F' C2 b$ _+ k. @
see Mardin et al., pp. 229–240.8 }" `7 w: W y
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发表于 2013-5-21 22:33
发表于 2013-5-22 10:29
