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: P. e2 R. }# a# a. I I* ~
5 }+ E- h( ` f2 \! d! m2 K% s( z5 C$ [! hVolume 25, Issue 3On the cover:
6 q8 Y, V8 b$ ^/ n" K' i% m2 kEpidermal growth factor (EGF) induces fast and efficient mitotic progression, 8 f: p' t; O& U) {9 U) A8 v
particularly in cancer cells, by accelerating centrosome separation. Thus, a
. [3 X, f2 ` h8 C: ?1 SHeLa cell treated with EGF proceeds faster through mitosis (left path) than a
% q8 m! y( |9 D: {+ _/ l$ |0 ]cell left untreated (right path), as visualized by confocal microscopy. / L4 z/ k) Z( ~; m! H
H2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear
' n3 }, C/ |; R: {- Fenvelope. For more information on the effect of EGF on centrosome separation and ! d+ W" \4 Z4 z2 D4 e. e- g+ `# I
mitotic progress, and on how this may relate to cancer therapeutic strategies, 2 k- Y& a/ E9 r! }- s4 o
see Mardin et al., pp. 229–240.# Q( p# ]4 p2 e, o" G2 G. |, I
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发表于 2013-5-21 22:33
发表于 2013-5-22 10:29
