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: e. `2 |6 k& l7 v8 Y* uVolume 25, Issue 3On the cover: $ e7 T5 Q& J' S7 Q7 u9 i5 @* N
Epidermal growth factor (EGF) induces fast and efficient mitotic progression,
. y* N4 F4 J) M: \; h$ k+ Bparticularly in cancer cells, by accelerating centrosome separation. Thus, a
3 H% _) E; b& b( V zHeLa cell treated with EGF proceeds faster through mitosis (left path) than a * g$ Y0 O$ _6 h- V
cell left untreated (right path), as visualized by confocal microscopy.
! `. c$ y: |8 z4 u" y6 DH2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear 8 C! x6 j0 P+ L. ]" v
envelope. For more information on the effect of EGF on centrosome separation and 0 @* N$ Y4 K7 `) t. l
mitotic progress, and on how this may relate to cancer therapeutic strategies, N5 z9 S' c; W D) z# p# t: x( r
see Mardin et al., pp. 229–240.
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发表于 2013-5-21 22:33
发表于 2013-5-22 10:29
