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/ Y3 ]7 K" @# ]; _9 C# @+ AVolume 25, Issue 3On the cover: 3 h" K; N. c2 j( e1 r
Epidermal growth factor (EGF) induces fast and efficient mitotic progression, - O5 y/ W8 X: P* J) H1 b) P% r
particularly in cancer cells, by accelerating centrosome separation. Thus, a 3 g. C) _4 s+ g3 p+ Y
HeLa cell treated with EGF proceeds faster through mitosis (left path) than a
: O* K0 Q- a, d+ K, Ucell left untreated (right path), as visualized by confocal microscopy.
) r/ Q% b) }/ VH2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear $ x& X' F, ^9 l0 b* V) \
envelope. For more information on the effect of EGF on centrosome separation and
! R- c( ], `* q2 ?8 ]4 `; b5 D3 _mitotic progress, and on how this may relate to cancer therapeutic strategies,
i6 l0 R% r \: r4 V0 J% f5 Y; lsee Mardin et al., pp. 229–240.2 c4 r t' G& V! F$ H" X8 n
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发表于 2013-5-21 22:33
