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# X* ?3 U: \( K2 UVolume 25, Issue 3On the cover:
( m% U% [1 t6 O, J* a3 V+ j5 S' DEpidermal growth factor (EGF) induces fast and efficient mitotic progression, / s4 W' @! \- h% j- F7 K
particularly in cancer cells, by accelerating centrosome separation. Thus, a " q8 Z( m V* k# n( G
HeLa cell treated with EGF proceeds faster through mitosis (left path) than a $ t0 ]# r- g6 b5 b" ]6 F
cell left untreated (right path), as visualized by confocal microscopy.
& l2 `# s, a0 T1 E. \H2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear
$ _3 ^& Y' b2 }$ s: G0 V- t [envelope. For more information on the effect of EGF on centrosome separation and 9 w3 w* E l( Q3 G) X3 H/ k
mitotic progress, and on how this may relate to cancer therapeutic strategies,
; z4 E: v* V- Ksee Mardin et al., pp. 229–240.9 N0 f3 r6 J7 a6 N3 o. X A, p
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发表于 2013-5-21 22:33
发表于 2013-5-22 10:29
