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Volume 25, Issue 3On the cover:
2 Z6 ^0 U2 w, z% x- qEpidermal growth factor (EGF) induces fast and efficient mitotic progression,
9 ?7 V& e. Q: ]+ e6 {$ m- @3 tparticularly in cancer cells, by accelerating centrosome separation. Thus, a
! `( E% N/ \: d9 B, SHeLa cell treated with EGF proceeds faster through mitosis (left path) than a
2 q0 N3 {) ~5 Fcell left untreated (right path), as visualized by confocal microscopy.
: _6 a |, r }& o1 S6 XH2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear
8 C p* u' g3 s; e8 nenvelope. For more information on the effect of EGF on centrosome separation and
& A2 ^8 l8 L/ b) w# Y4 D& Y, Pmitotic progress, and on how this may relate to cancer therapeutic strategies, 6 z! J; v) @4 R( k
see Mardin et al., pp. 229–240.
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发表于 2013-5-21 22:33
发表于 2013-5-22 10:29
