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5 A: @/ G" v/ t" |9 ~6 S4 w, ~Volume 78, Issue 4On the cover: Neural networks control
% O* a9 W( A9 a' |/ R4 Z k% |3 tintrinsic encoding of the circadian clock. Circadian pacemaking in the
! `# q" y# S0 S: P: u0 G5 g' esuprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and $ U, f& J) x$ f
intercellular properties, with the latter still poorly understood. In this issue
* Q7 V2 N, L; p/ N6 W" pof Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level , A* T$ I ^& l7 a4 n# Q$ o Q
encoding of circadian time, showing that specific activation of Gq-Ca2+ axis in
* q7 ~) }) s; }/ O" `! r4 Arestricted SCN neuronal subpopulations reprograms encoding of circadian time by
# u: k9 Y1 T0 X/ b6 ethe entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic 3 ~) b5 _" Y8 y( Z3 {, n: G: o0 p
connectivity. Concept by Marco Brancaccio; cover illustration by Joanna
: f8 g" B' c/ K3 ]; |Westmoreland.
: T5 \0 V, T* A0 w* X* s- B* A$ j U% }# V3 z) f% H7 x- v
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发表于 2013-5-23 23:46
