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* `# o9 B/ \) |' q( X1 PVolume 78, Issue 4On the cover: Neural networks control
4 h+ J5 A+ R* i, T# o- Vintrinsic encoding of the circadian clock. Circadian pacemaking in the
& `$ D$ B, D4 {( x: {suprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and ; k# |+ P% H( |5 V, E7 z8 h6 ^
intercellular properties, with the latter still poorly understood. In this issue
$ z/ `( u$ ]* q4 Eof Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level / K$ i. X9 M7 I' R, x! [8 ?$ w
encoding of circadian time, showing that specific activation of Gq-Ca2+ axis in
) R. _3 _8 s# S+ \4 `/ Arestricted SCN neuronal subpopulations reprograms encoding of circadian time by
! ] k1 a' R1 c" V# g0 F8 P( Othe entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic
6 y( I* M l5 q: ^: r7 Yconnectivity. Concept by Marco Brancaccio; cover illustration by Joanna
* P6 P8 d) j* }% U3 `9 N$ N+ j( vWestmoreland.
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发表于 2013-5-23 23:46
