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; r7 Z% C+ _/ N8 m; BVolume 78, Issue 4On the cover: Neural networks control 2 S7 m6 W- J" o* O2 {0 V6 E
intrinsic encoding of the circadian clock. Circadian pacemaking in the
# C# M: U- [% H, w' |/ {suprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and 3 k% }& p. [& x* e* j# s
intercellular properties, with the latter still poorly understood. In this issue 0 o5 `+ R, N! c: L: C' ?
of Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level 7 p- M% N5 ~1 I) R. T0 K0 U
encoding of circadian time, showing that specific activation of Gq-Ca2+ axis in
. b" E( V) E/ a+ d& trestricted SCN neuronal subpopulations reprograms encoding of circadian time by
+ ?, d2 R y5 I! a8 X" fthe entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic & H% @) o, |8 [7 r- z4 u3 v; t
connectivity. Concept by Marco Brancaccio; cover illustration by Joanna ! _* A: R0 o9 z! e+ c/ k
Westmoreland.+ q0 E: U! r+ e0 c
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发表于 2013-5-23 23:46
