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9 v2 f( H: Y! w1 V. T; A
3 P" m6 u( ^$ l% cVolume 78, Issue 4On the cover: Neural networks control . A9 Y" g* \& h3 w. n
intrinsic encoding of the circadian clock. Circadian pacemaking in the 5 W+ h7 @% v5 o; P. P
suprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and 8 W5 X' R$ |: f% G
intercellular properties, with the latter still poorly understood. In this issue k' T8 [7 k# P$ `. F6 ?% I5 {
of Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level / ]+ c4 A. B! S* K- M/ V# n
encoding of circadian time, showing that specific activation of Gq-Ca2+ axis in ) }( K/ k7 O, F9 d
restricted SCN neuronal subpopulations reprograms encoding of circadian time by 5 |# X* {/ V4 O& A: |* l" O
the entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic / T0 D* s, y' ?& S" q/ Q: L
connectivity. Concept by Marco Brancaccio; cover illustration by Joanna " y% h% M; ^+ y* H8 D0 r
Westmoreland., {7 M3 ^1 Y) W7 w0 a* e4 f
m& i' x& s0 W3 h3 s* h
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发表于 2013-5-23 23:46
