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Volume 78, Issue 4On the cover: Neural networks control " s4 R; F$ S3 t+ G: `
intrinsic encoding of the circadian clock. Circadian pacemaking in the ) G0 b) Y4 k3 w: N5 R- z8 \! e9 A
suprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and 3 t: _- k; V$ r1 `$ @" j
intercellular properties, with the latter still poorly understood. In this issue 3 @8 [+ X, z) e" A3 z0 T7 D- B6 |4 ^
of Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level 6 n% h( m! ^ c; T1 ^5 E6 d( Q
encoding of circadian time, showing that specific activation of Gq-Ca2+ axis in 7 b( |7 O9 @+ r; K# u4 U! q
restricted SCN neuronal subpopulations reprograms encoding of circadian time by 7 p: C/ Z+ G5 _9 R" r3 x2 L
the entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic 7 d2 p7 s4 n$ a6 G' J' Q; U8 {
connectivity. Concept by Marco Brancaccio; cover illustration by Joanna
1 h+ V; Y) a5 a% H1 [& b6 c. ZWestmoreland.
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发表于 2013-5-23 23:46
