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Volume 78, Issue 4On the cover: Neural networks control
2 \7 v8 c4 S w5 eintrinsic encoding of the circadian clock. Circadian pacemaking in the
' l2 |, g8 D* Q& Usuprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and 2 H J# F8 x; V; g
intercellular properties, with the latter still poorly understood. In this issue
, s) [! |( {$ `# ^1 iof Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level . _8 ]* R' |7 e2 q
encoding of circadian time, showing that specific activation of Gq-Ca2+ axis in / v3 t' p% @5 @$ g4 L
restricted SCN neuronal subpopulations reprograms encoding of circadian time by
7 }& o4 D7 H# ^0 Jthe entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic
4 U0 y! K+ R6 W' y3 l" ~( uconnectivity. Concept by Marco Brancaccio; cover illustration by Joanna ) k) D: h3 ?2 r& W! x$ O1 G5 M" c# m
Westmoreland.
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