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) F2 c( X6 S' t' I/ DVolume 78, Issue 4On the cover: Neural networks control 3 w% Z- A1 Q. e; t3 x' Q5 C
intrinsic encoding of the circadian clock. Circadian pacemaking in the
7 C( E, C! C/ e; f% ^) Asuprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and 5 J6 y( h; E8 G5 a
intercellular properties, with the latter still poorly understood. In this issue
5 o1 M+ M, h! b: ^) Fof Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level
9 F6 _3 D& N3 O8 I: Uencoding of circadian time, showing that specific activation of Gq-Ca2+ axis in
8 j: @ q! e* Z! ]2 v) wrestricted SCN neuronal subpopulations reprograms encoding of circadian time by M% {2 A" t1 Y r7 g3 s* [7 B
the entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic ) Z8 v; D8 [1 C6 }
connectivity. Concept by Marco Brancaccio; cover illustration by Joanna ) ?+ p( B! y# P3 [7 A j0 c
Westmoreland.( T T3 i# T* Y
7 b( s7 i8 y! T9 Y2 \. x0 I
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发表于 2013-5-23 23:46
