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2013年12月5日 Cell
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. G3 q8 b9 J& X6 Y2 A5 December, 2013 Volume 155, Issue 65 s; S$ [: C/ l8 g9 Z; |6 s
On the cover: The nuclear pore complex
/ i, Z& B+ d! j" O(NPC) is a large multisubunit structure that regulates the exchange of ( B0 r& r' I o, y8 h3 P
macromolecules between the nucleus and the cytoplasm. In this issue, Huy et al. 3 X6 z0 {% u- f* Y; J, P$ }
(pp. 1233–1243) use an integrated approach to establish the blueprint for the
* Q: s8 O' R# cstructure of the NPC scaffold in humans and explain how changes in the diameter
2 t3 B3 u3 _# y' W2 e4 i! bof this scaffold enable the transport of large cargoes. Cover artwork by Khanh
; G8 J# n- ]+ C" u" D- aHuy Bui. Original photo by Alan Levine.
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