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2013年12月5日 Cell I O0 X0 a" t, T! v
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. P. u0 q* t& ?$ |5 December, 2013 Volume 155, Issue 60 k* V9 [1 L1 R% W" Q6 E( b' G- `5 \
On the cover: The nuclear pore complex " P. Y, e6 s( F/ M4 _9 @
(NPC) is a large multisubunit structure that regulates the exchange of ! k4 ]8 B5 D% n6 d; k/ }4 F: ~
macromolecules between the nucleus and the cytoplasm. In this issue, Huy et al.
/ j) P1 F1 ]# B8 Y; f- e(pp. 1233–1243) use an integrated approach to establish the blueprint for the
+ ?( @: C9 w, O) Zstructure of the NPC scaffold in humans and explain how changes in the diameter 6 |3 a w& c6 r
of this scaffold enable the transport of large cargoes. Cover artwork by Khanh
, k' x4 S! A7 o+ WHuy Bui. Original photo by Alan Levine. w! Z2 q+ l+ F! D0 _! v
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