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2013年12月5日 Cell0 M, n; K# e& Y; L3 ^' W" _2 E7 _6 x
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5 December, 2013 Volume 155, Issue 6! G$ s9 j3 q9 j; o* s4 H
On the cover: The nuclear pore complex
4 ^# ?# [$ i5 N* m+ C1 P, G(NPC) is a large multisubunit structure that regulates the exchange of
$ [+ }4 ~$ M0 @6 v5 v3 X+ ^4 Y Kmacromolecules between the nucleus and the cytoplasm. In this issue, Huy et al. 9 H8 v" S. w; Q0 A. Q2 F; k" G$ w. }
(pp. 1233–1243) use an integrated approach to establish the blueprint for the
& y: J+ J& b1 C6 ]" M: Tstructure of the NPC scaffold in humans and explain how changes in the diameter $ \ k4 ~6 \* I/ w
of this scaffold enable the transport of large cargoes. Cover artwork by Khanh
; n; r5 b# t$ {* dHuy Bui. Original photo by Alan Levine.
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